| Description : |
The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
69.06 kDa |
| AA Sequence : |
MPALSRWASLPGPSMREAAFMYSTA VAIFLVILVAALQGSAPRESPLPYH IPLDPEGSLELSWNVSYTQEAIHFQ LLVRRLKAGVLFGMSDRGELENADL VVLWTDGDTAYFADAWSDQKGQIHL DPQQDYQLLQVQRTPEGLTLLFKRP FGTCDPKDYLIXDGTVHLVYGILEE PFRSLEAINGSGLQMGLQRVQLLKP NIPEPELPSDACTMEVQAPNIQIPS QETTYWCYIKELPKGFSRHHIIKYE PIVTKGNEALVHHMEVFQCAPEMDS VPHFSGPCDSKMKPDRLNYCRHVLA AWALGAKAFYYPEEAGLAFGGPGSS RYLRLEVHYHNPLVIEGRNDSSGIR LYYTAKLRRFNAGIMELGLVYTPVM AIPPRETAFILTGYCTDKCTQLALP PSGIHIFASQLHTHLTGRKVVTVLV RDGREWEIVNQDNHYSPHFQEIRML KKVVSVHPGDVLITSCTYNTEDREL ATVGGFGILEEMCVNYVHYYPQTQL ELCKSAVDAGFLQKYFHLINRFNNE DVCTCPQASVSQQFTSVPWNSFNRD VLKALYSFAPISMHCNKSSAVRFQG EWNLQPLPKVISTLEEPTPQCPTSQ GRSPAGPTVVSIGGGKGSGPTRTRR LEQKLISEEDLAANDILDYKDDDDK V |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
