ddit3
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  • Official Full Name
  • DNA-damage-inducible transcript 3
  • Background
  • GADD 153 has been described as a growth arrest and DNA damage-inducible gene that encodes a C/EBP-related nuclear protein. GADD153 expression is induced by a variety of cellular stresses, inducing nutrient deprivation and merabolic perturbations. GADD153 functions to block cells in G1 to S phase in cell cycle progression and acts by dimerizing with other C/EBP proteins to direct GADD153 dimers away from “classical” C/EBP binding sites, recognizing instead unique “nonclassical” sites.
  • Synonyms
  • DDIT3; DNA-damage-inducible transcript 3; DNA damage-inducible transcript 3 protein; C/EBP zeta; CHOP; CHOP10; GADD153; DDIT-3; c/EBP-homologous protein 10; CCAAT/enhancer-binding protein homologous protein; growth arrest and DNA damage-inducible protein GADD153; CEBPZ; CHOP-10; MGC4154
Cat.#:DDIT3-217HTag:GST/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DDIT3 Protein, GST/His-tagged
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Cat.#:DDIT3-2442HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DDIT3 Protein, GST-tagged
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Cat.#:DDIT3-126HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DDIT3 protein, T7/His-tagged
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Cat.#:DDIT3-130HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DNA-damage-inducible Transcript 3
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Cat.#:DDIT3-1361HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DNA-damage-inducible Transcript 3, GST-tagged
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Cat.#:DDIT3-26512THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DDIT3, His-tagged
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Cat.#:DDIT3-4948HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DNA-Damage-Inducible Transcript 3, His-tagged
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Cat.#:DDIT3-859HTag:GST/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DDIT3 Protein, GST-His-tagged
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Cat.#:Ddit3-1655MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ddit3 protein, His & GST-tagged
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Cat.#:DDIT3-4387MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DDIT3 Protein
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Cat.#:DDIT3-1206RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey DDIT3 Protein, His-tagged
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Cat.#:DDIT3-5226ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DDIT3
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Cat.#:DDIT3-7027HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DDIT3 293 Cell Lysate
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Involved Pathway

DDIT3 involved in several pathways and played different roles in them. We selected most pathways DDIT3 participated on our site, such as ATF-2 transcription factor network, ATF4 activates genes, ATF6-alpha activates chaperone genes, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDIT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ATF-2 transcription factor network
CDK4; CREB1; KCNA3; JUNB; RUVBL2; DUSP5; MAPK14; KAT5; JDP2; CBFB
ATF4 activates genes
DDIT3; EXOSC8; DCP2; KCNA3
ATF6-alpha activates chaperone genes
KCNA3; DDIT3
ATF6-alpha activates chaperones
DDIT3; YY2; KCNA3
Adipogenesis
NR2F1; CEBPB; SPOCK1; KLF6A; NDN; KCNA3; NCOA2; CNTFR; SMAD3B; DLK1
MAPK signaling pathway
RASGRP3; RASGRF2; MKNK2B; EGFRA; CACNA1SB; AKT3A; MAPK3; TGFB1; ACVR1C; RAP1B
Metabolism of proteins
LMAN2; PFDN2; YIF1A; SPCS3; TIMM21; SERPINA7; DDX11; GPR120; DDOST; ASNA1
Non-alcoholic fatty liver disease (NAFLD)
NDUFC2; CASP7; NR1H3; NDUFA11; PRKAB2; MAPK8; ADIPOQ; COX7A2L; LEP; ADIPOR1

Protein Function

DDIT3 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, cAMP response element binding protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DDIT3 itself. We selected most functions DDIT3 had, and list some proteins which have the same functions with DDIT3. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ISX; MNDA; IGHMBP2; SOX21; TFB1M; ASCL1; BLZF1; HOXB2; PCXB; JRK
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein ZNF718; FOXA2; TCF7L2; NKX6-1; NFIB; ZNF680; TFE3B; NR1D1; GATA1; FOS
Function cAMP response element binding protein binding
Related Protein CRTC1A; ATF2; CRTC2; DDIT3; CRTC3; KCNA3; CREM; CREB3; CRTC1; DAPK3
Function leucine zipper domain binding
Related Protein CRX; AATF; ERC1; PMF1; MKL1; DAPK3; KCNA3; DDIT3; NRL; ATF4
Function protein binding
Related Protein DPM2; GJD3; UBXN8; AJUBA; NADSYN1; TRPC4; AGTR2; DSG1A; KCNH7; ACO1
Function protein heterodimerization activity
Related Protein NKX2-5; FLOT1; HOMER1; CUL3; HIST1H3H; HIST1H47; DMRTA2; TAF9; PDZD7; DRD2
Function NOT protein homodimerization activity
Related Protein NUDT16L1; MYO9B; KCNA3; MSH3; MSH6; MECOM; MLXIPL; DDIT3; EXT2
Function transcription corepressor activity
Related Protein SAP30; ENO1; TFAP2B; ZBTB32; C1D; ZHX2; TRIM28; DR1; ZNF136; E4F1
Function transcription factor activity, sequence-specific DNA binding
Related Protein TSC22D1; ZNF577; EGR2A; ZNF189; RUNX1; GTF2I; HOXB8A; PBX3B; ZNF490; RCOR2
Function transcription factor binding
Related Protein DAXX; NR0B2A; SLC26A5; Ar; NFKBIA; ZEB1; RBL1; HEY1; FOXO4; HDAC9
Function transcription regulatory region DNA binding
Related Protein HNF4A; GABPB1; ZNF613; PAX2; WNT11; DDIT3; HINFP; BRD7; ZNF174; CBX4
Function transcription regulatory region sequence-specific DNA binding
Related Protein BACH1B; SUV39H2; NFE2L1; MEF2CA; TBX18; ZNF658; NR5A1A; POU5F1; SOX4; NFE2L2B
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein KCNA3; NR2E1; SP1; MITFB; FOXJ2; ZIC3; SPI1; PBX1; GLI3; WT1

Interacting Protein

DDIT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDIT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDIT3.
CEBPG; BATF; DBP; BACH1; CREB3; FOS; HBZ; ATF2; FOSL2; JUNB; ATF7; CEBPB; ATF3

DDIT3 Related Articles

Richards, M; Phoon, CW; et al. A New Class of Pluripotent Stem Cell Cytotoxic Small Molecules. PLOS ONE 9:-(2014).
Carvalheira, GM; Nozima, BHN; et al. DDIT3, STT3A (ITM1), ARG2 and FAM129A (Niban, C1orf24) in diagnosing thyroid carcinoma: variables that may affect the performance of this antibody-based test and promise. MODERN PATHOLOGY 26:611-613(2013).