|Official Full Name||dentin matrix acidic phosphoprotein 1|
|Background||Dentin matrix protein 1, also known as DMP-1, is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in DMP-1 are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia.|
|Synonyms||DMP1; dentin matrix acidic phosphoprotein 1; dentin matrix acidic phosphoprotein; dentin matrix protein 1; ARHP; ARHR; DMP-1|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
DMP1 involved in several pathways and played different roles in them. We selected most pathways DMP1 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with DMP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|ECM proteoglycans||DMP1; LRP4; DAG1; BGNB; COL9A3; PTPRS; COMP; VCANB; MATN4; SPARC|
|Extracellular matrix organization||EFEMP1; LTBP3; CTSG; LOX; FBLN2; ADAMTS18; LOXL3; HAPLN1; COL23A1; FURINB|
DMP1 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by DMP1 itself. We selected most functions DMP1 had, and list some proteins which have the same functions with DMP1. You can find most of the proteins on our site.
|calcium ion binding||ANXA6; PCDHGC3; ANXA3A; PCDHGA8; ANXA2; DSG2.1; EGFEM1; PCDH17; ZZEF1; EFEMP1|
|extracellular matrix binding||CD248; ITGAV; BGN; ITGB3; GPR56; SPP1; DCN; FBLN2; SPARC; SPOCK2|
|integrin binding||COL5A1; THBS4; ANGPTL3; LAMB2; JAM3; WISP1A; MMP14; ICAM1; ADAM25; FAP|
DMP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DMP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DMP1.