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DMP1

  • Official Full Name

    dentin matrix acidic phosphoprotein 1

  • Overview

    Dentin matrix protein 1, also known as DMP-1, is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in DMP-1 are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia.
  • Synonyms

    DMP1; dentin matrix acidic phosphoprotein 1; dentin matrix acidic phosphoprotein; dentin matrix protein 1; ARHP; ARHR; DMP-1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Dog
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • His|SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DMP1-662H Active Recombinant Human DMP1, His-tagged Mammalian cells His
Human DMP1-2706H Recombinant Human DMP1 Protein, GST-tagged Wheat Germ GST
Human DMP1-503H Recombinant Human DMP1 Mammalian Cell His
Human DMP1-3790H Active Recombinant Human DMP1 protein, His-tagged HEK293 His Met1-Tyr513
Human DMP1-1977HCL Recombinant Human DMP1 cell lysate Human Cell N/A
Human DMP1-2803H Recombinant Human DMP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DMP1-2212H Recombinant Human DMP1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human DMP1-1973H Recombinant Human DMP1 Protein (Lys17-Tyr513), C-His tagged Mammalian cells C-His Lys17-Tyr513
Human DMP1-2803H-B Recombinant Human DMP1 Protein Pre-coupled Magnetic Beads HEK293
Human DMP1-2398H Recombinant Human DMP1 Protein (17-513 aa), His-tagged Yeast His 17-513 aa
Human DMP1-6727H Recombinant Human DMP1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Dmp1-407M Active Recombinant Mouse Dentin Matrix Protein 1, His-tagged Mammalian cells His
Mouse DMP1-4647M Recombinant Mouse DMP1 Protein Mammalian Cell His
Mouse Dmp1-2585M Recombinant Mouse Dmp1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Dmp1-2412M-B Recombinant Mouse Dmp1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Dmp1-2412M Recombinant Mouse Dmp1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Dog DMP1-2032D Recombinant Dog DMP1 Protein (1-435 aa), His-SUMO-tagged E.coli His/SUMO 1-435 aa
Chicken DMP1-7116C Recombinant Chicken DMP1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DMP1 Related Articles
  • DMP1 Related Research Area

DMP1 involved in several pathways and played different roles in them. We selected most pathways DMP1 participated on our site, such as ECM proteoglycans, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with DMP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ECM proteoglycansMATN1;FMOD;ITGB3A;ASPN;ACAN;MUSK;PTPRS;COMP;COL9A3
Extracellular matrix organizationCOL8A1A;FBLN1;P3H2;COL11A1B;FURINB;TIMP2B;MMP11;LOX;COL3A1

DMP1 has several biochemical functions, for example, calcium ion binding, extracellular matrix binding, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DMP1 itself. We selected most functions DMP1 had, and list some proteins which have the same functions with DMP1. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingPCDH1GB9;ACTN2;EFCAB6;RCVRN;AP1S2;SPARCL1;ALOX15B;LRP2;SLC24A5
extracellular matrix bindingDCN;GPR56;SPP1;VTN;SPARC;SID4;CD248;TGFBI;VEGFA
integrin bindingLAMB2;FAP;ADAM22;ITGB1;GFAP;THBS1;P4HB;CXADR;ESM1

DMP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DMP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DMP1.

Sapir-Koren, R; Livshits, G; et al. Osteocyte control of bone remodeling: is sclerostin a key molecular coordinator of the balanced bone resorption-formation cycles?. OSTEOPOROSIS INTERNATIONAL 25:2685-2700(2014).
Sato, S; Hashimoto, J; et al. Novel sandwich ELISAs for rat DMP1: Age-related decrease of circulatory DMP1 levels in male rats. BONE 57:429-436(2013).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can DMP1 be a target for drug development? 01/22/2021

Yes, targeting DMP1 in drug development may offer new avenues for treating conditions related to bone and dentin abnormalities.

Are there therapeutic applications of DMP1 in bone-related conditions? 10/14/2020

Research suggests that DMP1 may have therapeutic potential in promoting bone regeneration and treating conditions like osteoporosis.

How does DMP1 contribute to the repair of bone fractures? 06/06/2020

DMP1 is involved in the repair and remodeling of bone tissue after fractures by influencing the mineralization and structural integrity of the newly formed bone.

How can DMP1 be utilized in diagnostic procedures? 11/21/2018

DMP1 levels can be measured in biological samples, such as blood or saliva, to assess the potential presence of dental or skeletal disorders and to monitor disease progression.

Is there a connection between DMP1 and periodontal disease? 02/24/2018

Some studies suggest that DMP1 may play a role in maintaining the health of periodontal tissues, and alterations in its expression could be associated with periodontal disease.

Customer Reviews (3)

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Reviews
02/01/2022

    This commitment to excellence ensures that researchers are provided with the most advanced and reliable tools for their investigations.

    12/16/2020

      The DMP1 protein offers numerous advantages in trials and research experiments.

      11/01/2017

        Not only does it provide reliable and consistent results due to its high quality and purity, but it also holds significant value in understanding cellular processes and disease mechanisms.

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