DMP1
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Official Full Name
dentin matrix acidic phosphoprotein 1
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Overview
Dentin matrix protein 1, also known as DMP-1, is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in DMP-1 are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. -
Synonyms
DMP1; dentin matrix acidic phosphoprotein 1; dentin matrix acidic phosphoprotein; dentin matrix protein 1; ARHP; ARHR; DMP-1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Dog
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- Human Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- C
- His
- GST
- His (Fc)
- Avi
- His|SUMO
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- DMP1 Related Articles
- DMP1 Related Research Area
DMP1 involved in several pathways and played different roles in them. We selected most pathways DMP1 participated on our site, such as ECM proteoglycans, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with DMP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ECM proteoglycans | ACAN;ITGB3A;HAPLN1;DMP1;SPARC;COMP;MATN1;BGNA;PTPRS |
Extracellular matrix organization | LOC100686744;ADAM15;COL6A1;ADAMTS1;COL1A1;LOXL2;COL23A1;BSG;F11R.2 |
DMP1 has several biochemical functions, for example, calcium ion binding, extracellular matrix binding, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DMP1 itself. We selected most functions DMP1 had, and list some proteins which have the same functions with DMP1. You can find most of the proteins on our site.
Function | Related Protein |
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calcium ion binding | EGFL6;SYT1;CDH16;MYLPFA;TBC1D8B;NRXN1;LTBP3;MAN1B1;CETN1 |
extracellular matrix binding | VTN;GPR56;ITGB3;VEGFA;ITGAV;SPOCK2;FBLN2;SPARC;CD248 |
integrin binding | VTN;ACTN4;S1PR3;ACTN2;NF2;ADAM10;PXN;ACTN1;SRC |
DMP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DMP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DMP1.
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, targeting DMP1 in drug development may offer new avenues for treating conditions related to bone and dentin abnormalities.
Research suggests that DMP1 may have therapeutic potential in promoting bone regeneration and treating conditions like osteoporosis.
DMP1 is involved in the repair and remodeling of bone tissue after fractures by influencing the mineralization and structural integrity of the newly formed bone.
DMP1 levels can be measured in biological samples, such as blood or saliva, to assess the potential presence of dental or skeletal disorders and to monitor disease progression.
Some studies suggest that DMP1 may play a role in maintaining the health of periodontal tissues, and alterations in its expression could be associated with periodontal disease.
Customer Reviews (3)
Write a reviewThis commitment to excellence ensures that researchers are provided with the most advanced and reliable tools for their investigations.
The DMP1 protein offers numerous advantages in trials and research experiments.
Not only does it provide reliable and consistent results due to its high quality and purity, but it also holds significant value in understanding cellular processes and disease mechanisms.
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