DMP1

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DMP1

Official Full Name dentin matrix acidic phosphoprotein 1
Background Dentin matrix protein 1, also known as DMP-1, is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in DMP-1 are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia.
Synonyms DMP1; dentin matrix acidic phosphoprotein 1; dentin matrix acidic phosphoprotein; dentin matrix protein 1; ARHP; ARHR; DMP-1
    • Species :
    • Chicken
    • Dog
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • NS0
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • SUMO
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Dog DMP1-2032D Recombinant Dog DMP1 Protein (1-435 aa), His-SUMO-tagged E.coli His/SUMO
    Human DMP1-2398H Recombinant Human DMP1 Protein (17-513 aa), His-tagged Yeast His
    Human DMP1-1977HCL Recombinant Human DMP1 cell lysate Human Cell N/A
    Human DMP1-2212H Recombinant Human DMP1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human DMP1-2706H Recombinant Human DMP1 Protein, GST-tagged Wheat Germ GST
    Human DMP1-3790H Recombinant Human DMP1, His tagged Human Cell His
    Human DMP1-503H Recombinant Human DMP1 Mammalian Cell His
    Human DMP1-662H Recombinant Human DMP1, His-tagged NS0 His
    Mouse Dmp1-407M Recombinant Mouse Dentin Matrix Protein 1, His-tagged NS0 His
    Mouse DMP1-4647M Recombinant Mouse DMP1 Protein Mammalian Cell His
    Chicken DMP1-7116C Recombinant Chicken DMP1 Mammalian Cell His

    DMP1 involved in several pathways and played different roles in them. We selected most pathways DMP1 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with DMP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ECM proteoglycans DMP1; LRP4; DAG1; BGNB; COL9A3; PTPRS; COMP; VCANB; MATN4; SPARC
    Extracellular matrix organization EFEMP1; LTBP3; CTSG; LOX; FBLN2; ADAMTS18; LOXL3; HAPLN1; COL23A1; FURINB

    DMP1 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by DMP1 itself. We selected most functions DMP1 had, and list some proteins which have the same functions with DMP1. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding ANXA6; PCDHGC3; ANXA3A; PCDHGA8; ANXA2; DSG2.1; EGFEM1; PCDH17; ZZEF1; EFEMP1
    extracellular matrix binding CD248; ITGAV; BGN; ITGB3; GPR56; SPP1; DCN; FBLN2; SPARC; SPOCK2
    integrin binding COL5A1; THBS4; ANGPTL3; LAMB2; JAM3; WISP1A; MMP14; ICAM1; ADAM25; FAP

    DMP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DMP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DMP1.

    Sapir-Koren, R; Livshits, G; et al. Osteocyte control of bone remodeling: is sclerostin a key molecular coordinator of the balanced bone resorption-formation cycles?. OSTEOPOROSIS INTERNATIONAL 25:2685-2700(2014).
    Sato, S; Hashimoto, J; et al. Novel sandwich ELISAs for rat DMP1: Age-related decrease of circulatory DMP1 levels in male rats. BONE 57:429-436(2013).

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