dmp1
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  • Official Full Name
  • dentin matrix acidic phosphoprotein 1
  • Background
  • Dentin matrix protein 1, also known as DMP-1, is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in DMP-1 are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia.
  • Synonyms
  • DMP1; dentin matrix acidic phosphoprotein 1; dentin matrix acidic phosphoprotein; dentin matrix protein 1; ARHP; ARHR; DMP-1
Cat.#:DMP1-2032DTag:His-SUMO
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog DMP1 Protein (1-435 aa), His-SUMO-tagged
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Cat.#:DMP1-2398HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human DMP1 Protein (17-513 aa), His-tagged
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Cat.#:DMP1-2212HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human DMP1 Protein, MYC/DDK-tagged
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Cat.#:DMP1-2706HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DMP1 Protein, GST-tagged
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Cat.#:Dmp1-407MTag:His
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Dentin Matrix Protein 1, His-tagged
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Cat.#:DMP1-3790HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human DMP1, His tagged
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Cat.#:DMP1-503HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human DMP1
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Cat.#:DMP1-662HTag:His
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human DMP1, His-tagged
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Cat.#:DMP1-4647MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DMP1 Protein
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Cat.#:DMP1-7116CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DMP1
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Cat.#:DMP1-1977HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human DMP1 cell lysate
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Involved Pathway

DMP1 involved in several pathways and played different roles in them. We selected most pathways DMP1 participated on our site, such as ECM proteoglycans, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with DMP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ECM proteoglycans
PTPRS; VCANB; BGNB; COMP; ITGB3A; COL9A1; MUSK; MATN3B; LRP4; MATN1
Extracellular matrix organization
MMP12; COL4A4; MUSK; CAPNS1; MMP15; MFAP1B; ADAMTS18; NID2; PCOLCEA; TRAPPC4

Protein Function

DMP1 has several biochemical functions, for example, calcium ion binding, extracellular matrix binding, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DMP1 itself. We selected most functions DMP1 had, and list some proteins which have the same functions with DMP1. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein NCALD; PCDHA10; TTN; SYT11; LPCAT1; FKBP7; PVALB8; EFCAB5; PCDHGC4; MBL2
Function extracellular matrix binding
Related Protein ITGAV; VTN; GPR56; CD248; VEGFA; FBLN2; SPOCK2; SPARC; ITGB3; SID4
Function integrin binding
Related Protein ESM1; NIPAL1; ITGA3; ADAM9; PPAP2B; WISP1; EMP2; DST; ADAM10; THBS4

DMP1 Related Articles

Sapir-Koren, R; Livshits, G; et al. Osteocyte control of bone remodeling: is sclerostin a key molecular coordinator of the balanced bone resorption-formation cycles?. OSTEOPOROSIS INTERNATIONAL 25:2685-2700(2014).
Sato, S; Hashimoto, J; et al. Novel sandwich ELISAs for rat DMP1: Age-related decrease of circulatory DMP1 levels in male rats. BONE 57:429-436(2013).