| Description : |
Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
54.13 kDa |
| AA Sequence : |
MKISILLMFLWGLSCALPVTRYQNN ESEDSEEWKGHLAQAPTPPLANEDP SDCTQSEEGLGSDDHQYIYRLAGGF SRSTGKGGDDKDDDEDDSGDDTFGD DDSGPGPKDRQEGGNSRLGSDEDSD DTIQASEESAPQGQDSAQDTTSESR ELDNEDRVDSKPEGGDSTQESESEE HWVGGGSDGESSHGDGSELDDEGMQ SDDPESIRSERGNSRMNSAGMKSKE SGENSEQANTQDSGGSQLLEHPSRK IFRKSRISEEDDRSELDDNNTMEEV KSDSTENSNSRDTGLSQPRRDSKGD SQEDSKENLSQEESQNVDGPSSESS QEANLSSQENSSESQEEVVSESRGD NPDPTTSYVEDQEDSDSSEEDSSHT LSHSKSESREEQADSESSESLNFSE ESPESPEDENSSSQEGLQSHSSSAE SQSEESHSEEDDSDSQDSSRSKEDS NSTESKSSSEEDGQLKNIEIESRKL TVDAYHNKPIGDQDDNDCQDGYTRT RPLEQKLISEEDLAANDILDYKDDD DKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
