dnm1
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  • Official Full Name
  • dynamin 1
  • Background
  • This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3 region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described.
  • Synonyms
  • DNM1; dynamin 1; DNM; dynamin-1
Cat.#:DNM1-06HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human DNM1 protein, MYC/DDK-tagged
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Cat.#:DNM1-12103HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DNM1, GST-tagged
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Cat.#:Dnm1-2028MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Dnm1 protein, His & T7-tagged
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Cat.#:DNM1-4735MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DNM1 Protein
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Cat.#:DNM1-1922RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat DNM1 Protein
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Involved Pathway

DNM1 involved in several pathways and played different roles in them. We selected most pathways DNM1 participated on our site, such as Adaptive Immune System, Axon guidance, Bacterial invasion of epithelial cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with DNM1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
CD200R1; RNF34; DNM1; UFL1; THEM4; KIF11; WWP1; GRAP2A; ICAM4; TRIM50
Axon guidance
TRPC7; PPP3CA; EFNB3; SCN3B; ARPC3; ARHGEF12; ABLIM2; ACTR2B; ARHGEF28; MAPK3
Bacterial invasion of epithelial cells
CDH1; CBL; DNM2; PIK3CG; CAV3; ARPC1A; ARPC4; CDC42; SEPT2; RAC1
CXCR3-mediated signaling events
DNM1; CXCL13; MAPKAP1
CXCR4-mediated signaling events
PAG1; ADRBK1; GNB2L1; CFL1; BLK; MAPKAP1; DNM1; CSK; ARR3; GNA13
Developmental Biology
RASGRP1; JAK3; MED31; EFNA2A; SCN2B; PLXNC1; MYL12B; PAQR3A; CACNG2B; LGI4
EGFR1 Signaling Pathway
GRB7; RALBP1; MAP3K2; CRKL; ZNF259; PTPN12; SH3BGRL; CEBPB; RGS5B; CEBPA
EPH-Ephrin signaling
EPHB4B; ACTR3; EPHB3A; EFNB2; EPHB4A; MYL12B; AP2M1; ARPC1B; ARPC4; CFL1

Protein Function

DNM1 has several biochemical functions, for example, GTP binding, GTPase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DNM1 itself. We selected most functions DNM1 had, and list some proteins which have the same functions with DNM1. You can find most of the proteins on our site.
Function
Related Protein
Function GTP binding
Related Protein GTPBP6; IRGF1; RASL11A; MX2; SEPT8B; RAB39B; SEPT7A; ARL15; RAP2AB; ARF6B
Function GTPase activity
Related Protein RAB41; DNM3A; RAP1B; GNAI2B; RND2; EEF2A.1; MFN2; TUBE1; RAB5B; RASD2
Function identical protein binding
Related Protein ATL3; GCC2; NPR2; KCNJ2; FRS3; HSP90AA1; SOD1; DYNLRB1; NIF3L1; CLDN3
Function poly(A) RNA binding
Related Protein FAM120B; EZR; RPS27A; UBE2L3; IMP3; RPL19; MYEF2; ZFP622; GANAB; ZFC3H1
Function protein binding
Related Protein HNF1A; PNMA5; PRCP; PRDX1; PBLD; VAMP8; LRRC4; Serpina1b; ARHGAP33; HGS
Function protein dimerization activity
Related Protein PRKRIR; HPSE; MYCLA; ATOH1; GARS; EBF4; STK4; AHRRB; HES2.2; FBXW11B
Function protein kinase binding
Related Protein DOK7; TSACC; PPP1R12C; TRIB3; STK11IP; CD3E; PPP1R12A; AP1B1; LSM2; MAML1

Interacting Protein

DNM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DNM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DNM1.
GRB2; SNX9; AMPH

DNM1 Related Articles

Devadas, D; Koithan, T; et al. Herpes Simplex Virus Internalization into Epithelial Cells Requires Na+/H+ Exchangers and p21-Activated Kinases but neither Clathrin-nor Caveolin-Mediated Endocytosis. JOURNAL OF VIROLOGY 88:13378-13395(2014).
Chowdhury, SM; Manepalli, P; et al. Graphene nanoribbons elicit cell specific uptake and delivery via activation of epidermal growth factor receptor enhanced by human papillomavirus E5 protein. ACTA BIOMATERIALIA 10:4494-4504(2014).