dnm1
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  • Official Full Name
  • dynamin 1
  • Background
  • This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3 region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described.
  • Synonyms
  • DNM1; dynamin 1; DNM; dynamin-1
Cat.#:DNM1-1380HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human DNM1 Protein (2-245 aa), His-tagged
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Cat.#:DNM1-458HTag:His-SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DNM1 Protein (2-245 aa), His-SUMO-tagged
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Cat.#:DNM1-06HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human DNM1 protein, MYC/DDK-tagged
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Cat.#:DNM1-12103HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DNM1, GST-tagged
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Cat.#:Dnm1-2028MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Dnm1 protein, His & T7-tagged
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Cat.#:DNM1-4735MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DNM1 Protein
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Cat.#:DNM1-1922RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat DNM1 Protein
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Involved Pathway

DNM1 involved in several pathways and played different roles in them. We selected most pathways DNM1 participated on our site, such as Adaptive Immune System, Axon guidance, Bacterial invasion of epithelial cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with DNM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
ITK; ARF1; RNF138; ARIH2; AP1S1; SIGLEC11; CXADR; CTSL1; KIF2C; LAIR1
Axon guidance
SEMA6C; SEMA3C; Unc5b; PTPRA; PPP3CC; NTN4; CNTN1; SCN9A; SCN2A; AP2S1
Bacterial invasion of epithelial cells
SEPT12; DNM3; RAC1; PIK3CG; CD2AP; PTK2; PIK3R1; CDH1; CTNNA2; ELMO1
CXCR3-mediated signaling events
DNM1; CXCL13; MAPKAP1
CXCR4-mediated signaling events
DNM1; ADRBK1; MAPKAP1; BLK; JAK2; GNA13; GNB2L1; ARR3; CFL1; PAG1
Developmental Biology
COL9A1; NTN1B; ARPC5; EVL; LEFTY1; FOXH1; TRPC4; EFNA1A; COL6A2; AP2B1
EGFR1 Signaling Pathway
GRB7; RGS5B; EPPK1; ARF4; CEBPA; SPRY2; PTK6; MTA2; CEACAM1; KRT17
EPH-Ephrin signaling
EPHB4B; EFNA2; MYL12A; ARPC3; MYL12B; KDR; EPHA10; EFNA4; AP2A2; EPHB3A

Protein Function

DNM1 has several biochemical functions, for example, GTP binding, GTPase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DNM1 itself. We selected most functions DNM1 had, and list some proteins which have the same functions with DNM1. You can find most of the proteins on our site.
Function
Related Protein
Function GTP binding
Related Protein RERGLA; GNAI2A; NOLC1; RAB37; RASL11A; RAB9B; RHOH; GEM; ERCC3; AGAP2
Function GTPase activity
Related Protein GTPBP1L; ARL8A; RAC1; GTPBP3; RHOT2; GNG3; GNAI1; IRGE4; ARF1; EEF2B
Function identical protein binding
Related Protein SNCAIP; CBX3; MIEF1; PAK2; SKP2; BAX; RYR2; PYDC3; USP15; VPS41
Function poly(A) RNA binding
Related Protein MOV10; MYEF2; ALG13; RAVER1; U2AF1; RPL32; SF3A1; POP7; HADHB; SLIRP
Function protein binding
Related Protein POLDIP3; SCN11A; CDC7; KIF3A; ZNHIT6; FRG1; SRGAP1; NLRC4; ELANE; RABL2A
Function protein dimerization activity
Related Protein TCF23; NEUROG2; MYC; NHLH1; MYCLA; ATOH8; TWIST1B; NEUROG1; ERBB2; ASCL3
Function protein kinase binding
Related Protein NME2; PTPN23; NEK6; HIF1A; RHOD; DBF4B; CDKN2A; USP37; NEFH; MEF2A

Interacting Protein

DNM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DNM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DNM1.
GRB2; SNX9; AMPH

DNM1 Related Articles

Devadas, D; Koithan, T; et al. Herpes Simplex Virus Internalization into Epithelial Cells Requires Na+/H+ Exchangers and p21-Activated Kinases but neither Clathrin-nor Caveolin-Mediated Endocytosis. JOURNAL OF VIROLOGY 88:13378-13395(2014).
Chowdhury, SM; Manepalli, P; et al. Graphene nanoribbons elicit cell specific uptake and delivery via activation of epidermal growth factor receptor enhanced by human papillomavirus E5 protein. ACTA BIOMATERIALIA 10:4494-4504(2014).