dnm1
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  • Official Full Name
  • dynamin 1
  • Background
  • This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3 region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described.
  • Synonyms
  • DNM1; dynamin 1; DNM; dynamin-1
Cat.#:DNM1-06HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human DNM1 protein, MYC/DDK-tagged
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Cat.#:DNM1-12103HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DNM1, GST-tagged
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Cat.#:Dnm1-2028MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Dnm1 protein, His & T7-tagged
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Cat.#:DNM1-4735MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DNM1 Protein
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Cat.#:DNM1-1922RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat DNM1 Protein
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Involved Pathway

DNM1 involved in several pathways and played different roles in them. We selected most pathways DNM1 participated on our site, such as Adaptive Immune System, Axon guidance, Bacterial invasion of epithelial cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with DNM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
LRRC41; RNF4; ITGB1B.1; GM11711; ERAP2; DYNC1LI2; ASB7; CTSO; SPSB1; UBA5
Axon guidance
AKAP9; DUSP6; DOCK1; ACTR2B; COL6A3; AP2A1; HFE2; SLIT3; COL4A5; KBTBD7
Bacterial invasion of epithelial cells
SEPT11; PIK3R2; CAV1; WAS; ELMO2; ARPC5L; ARPC3; SEPT9; CLTC; SEPT1
CXCR3-mediated signaling events
DNM1; CXCL13; MAPKAP1
CXCR4-mediated signaling events
BLK; ARR3; ADRBK1; GNB2L1; DNM1; MAPKAP1; PAG1; CFL1; GNA13; CRK
Developmental Biology
MED20; DPYSL3; CNTN1; SPRED1; FGF18B; MED6; SEMA3A; EFNA3; SCN3A; SEMA3AB
EGFR1 Signaling Pathway
MAP3K2; CEBPB; RBB4L; PTK6; WNK1; EEF1A1; REPS1; MTA2; DNM1; APPL2
EPH-Ephrin signaling
EFNA1A; EPHA4A; KALRN; EFNB1; EFNA5; AP2S1; EFNB3B; EFNA2; ARPC1B; ARPC3

Protein Function

DNM1 has several biochemical functions, for example, GTP binding, GTPase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DNM1 itself. We selected most functions DNM1 had, and list some proteins which have the same functions with DNM1. You can find most of the proteins on our site.
Function
Related Protein
Function GTP binding
Related Protein GTPBP8; RAB39A; RAB34A; MTIF2; GNAO1; ADSSL1; NUDT16; RAB43; ARL2; RAC3
Function GTPase activity
Related Protein MXC; RAB37; RAB13; DNM1; DNM2; TUBE1; TUBB6; RRAGCB; TUBA8L4; RAB25A
Function identical protein binding
Related Protein ALDH4A1; SERPINA1D; RBM10; PHYKPL; TP63; TRADD; TGFB3; THBS1; DACT3; CD74
Function poly(A) RNA binding
Related Protein ISG20L2; APEH; RPL10A; MATR3; AHNAK; HIST1H1E; ELAVL2; GLRX3; RPS3A; HIST1H4L
Function protein binding
Related Protein ZYX; GRM2; FAM86C; GPRASP1; DRAXIN; SIAH2; EFNB2; GLS; PTH2R; CLIC1
Function protein dimerization activity
Related Protein GPR139; FBXW11; ATP6V1C2; TWIST2; AHRR; HES2.1; HES2; HER9; NLGN1; HER8A
Function protein kinase binding
Related Protein DAXX; BCL10; IFNAR2; ERRFI1; MAP3K1; RPS6KA3; GOLGA2; CDK5R1; FER; LAX1

Interacting Protein

DNM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DNM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DNM1.
GRB2; SNX9; AMPH

DNM1 Related Articles

Devadas, D; Koithan, T; et al. Herpes Simplex Virus Internalization into Epithelial Cells Requires Na+/H+ Exchangers and p21-Activated Kinases but neither Clathrin-nor Caveolin-Mediated Endocytosis. JOURNAL OF VIROLOGY 88:13378-13395(2014).
Chowdhury, SM; Manepalli, P; et al. Graphene nanoribbons elicit cell specific uptake and delivery via activation of epidermal growth factor receptor enhanced by human papillomavirus E5 protein. ACTA BIOMATERIALIA 10:4494-4504(2014).