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Official Full Name dynamin 1
Background This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3 region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described.
Synonyms DNM1; dynamin 1; DNM; dynamin-1
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Yeast
    • Tag :
    • GST
    • His
    • SUMO
    • T7
    • Myc
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DNM1-1380H Recombinant Human DNM1 Protein (2-245 aa), His-tagged Yeast His
    Human DNM1-458H Recombinant Human DNM1 Protein (2-245 aa), His-SUMO-tagged E.coli His/SUMO
    Human DNM1-06H Recombinant Human DNM1 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human DNM1-12103H Recombinant Human DNM1, GST-tagged E.coli GST
    Mouse Dnm1-2028M Recombinant Mouse Dnm1 protein, His & T7-tagged E.coli His/T7
    Mouse DNM1-4735M Recombinant Mouse DNM1 Protein Mammalian Cell His
    Rat DNM1-1922R Recombinant Rat DNM1 Protein Mammalian Cell His

    DNM1 involved in several pathways and played different roles in them. We selected most pathways DNM1 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with DNM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System ASB8; KIFAP3; CTSLL; KLHL21; CTSK; NCR3LG1; UBE2V1; UBE2F; HECTD3; DCTN3
    Axon guidance ACTR3; COL9A1A; NRP1; ABL1; ACTR2; AP2A2; SEMA6B; SIAH2; ARPC2; SPTB
    Bacterial invasion of epithelial cells CLTA; VCL; ITGB1; SHC3; CDH1; PXN; ITGA5; RHOG; FN1; PIK3CB
    CXCR3-mediated signaling events MAPKAP1; DNM1; CXCL13
    CXCR4-mediated signaling events PAG1; MAPKAP1; ADRBK1; CSK; CRK; GNA13; ARR3; DNM1; CFL1; BLK
    Developmental Biology COL9A3; FGF20A; SCN3A; LGI2; ANK2B; CACNG8A; DCC; COL4A4; ITSN1; DUSP2
    EGFR1 Signaling Pathway RGS5B; ABI1B; TNK2; RBB4L; REPS2; CEACAM1; RGS16; EPPK1; CEBPB; TNIP1
    EPH-Ephrin signaling ARPC1A; SHB; EFNB3; AP2S1; EFNA3; AP2M1; KALRN; EPHA2; EPHB4B; KALRNB

    DNM1 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by DNM1 itself. We selected most functions DNM1 had, and list some proteins which have the same functions with DNM1. You can find most of the proteins on our site.

    Function Related Protein
    GTPase activity DIRAS3; RAB44; GIMAP7; DNM2B; TUBA8L4; RAC2; TUBA3E; RAB18; GNAV1; GNAS
    identical protein binding LYZ; MICALL1; KHDRBS1; ALCAMB; KCTD17; PFKM; GAPDH; HOOK1; CLPP; PRNP
    poly(A) RNA binding OTUD4; RBM4B; ILF3; THRAP3; HSP90AB1; GOT2; MBNL3; RPS9; DUSP11; CNOT1
    protein binding C19orf44; ACBD3; GTF2H4; BAIAP2L1; ADAM10; SKI; CD97; CAMK2D; B9D2; REST
    protein dimerization activity MESP1; HES4; HIF1AB; POLR2J2; EBF4; NCF4; DAO; NEUROD6A; EBF3A; STAT5B
    protein kinase binding SYN1; GYS1; CD4; CNPPD1; APC; PTPN1; TNIP2; HSP90AB1; TMEM173; RAB8A

    DNM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DNM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DNM1.

    GRB2; SNX9; AMPH

    Devadas, D; Koithan, T; et al. Herpes Simplex Virus Internalization into Epithelial Cells Requires Na+/H+ Exchangers and p21-Activated Kinases but neither Clathrin-nor Caveolin-Mediated Endocytosis. JOURNAL OF VIROLOGY 88:13378-13395(2014).
    Chowdhury, SM; Manepalli, P; et al. Graphene nanoribbons elicit cell specific uptake and delivery via activation of epidermal growth factor receptor enhanced by human papillomavirus E5 protein. ACTA BIOMATERIALIA 10:4494-4504(2014).

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