Recombinant Human DNM1, GST-tagged

• Cat.No.: DNM1-12103H
• Product Overview: Recombinant Human DNM1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3 region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 502-851a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: DNM1 dynamin 1 [ Homo sapiens ]
• Official Symbol: DNM1
• Synonyms: DNM1; dynamin 1; DNM; dynamin-1
• Gene ID: 1759
• mRNA Refseq: NM_001005336
• Protein Refseq: NP_001005336
• MIM: 602377
• UniProt ID: Q05193
• Chromosome Location: 9q34
• Pathway: Axon guidance, organism-specific biosystem; Bacterial invasion of epithelial cells, organism-specific biosystem; Bacterial invasion of epithelial cells, conserved biosystem; CXCR3-mediated signaling events, organism-specific biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Developmental Biology, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem
• Function: GTP binding; GTPase activity; hydrolase activity; identical protein binding; nucleotide binding; protein binding

Reviews

09/06/2022

Precise protein quantification, ensures data accuracy in our experiments.

05/26/2021

Accurate mass spectrometry, essential for precise proteomics analysis.

03/06/2021

Efficient peptide synthesis, accelerates our peptide research efficiently.

Q&As

How does DNM1 contribute to the development and maintenance of neural networks?

DNM1 contributes to the formation and maintenance of neural circuits, essential for brain function.

What role does DNM1 play in endocytosis and membrane trafficking within cells?

DNM1 plays a key role in endocytosis, facilitating membrane trafficking and cellular transport processes.

What are the mechanisms by which DNM1 modulates synaptic plasticity and learning?

DNM1 regulates synaptic plasticity, crucial for learning and memory formation.

How do alterations in DNM1 expression or function affect neurodegenerative diseases?

Changes in DNM1 function can influence the progression of neurodegenerative diseases, affecting neuronal health and connectivity.

How does DNM1 (Dynamin 1) regulate synaptic vesicle recycling and neurotransmitter release in neurons?

DNM1 is crucial for synaptic vesicle recycling, controlling neurotransmitter release at synapses.

How does DNM1 influence cellular signaling pathways, particularly in the nervous system?

DNM1 impacts cellular signaling in neurons, influencing various neuronal activities and responses.

What is the impact of DNM1 mutations on neurological disorders, such as epilepsy?

Mutations in DNM1 are linked to neurological conditions like epilepsy, affecting synaptic function.