dnmt1
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  • Official Full Name
  • DNA (cytosine-5-)-methyltransferase 1
  • Background
  • DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
  • Synonyms
  • DNMT1; DNA (cytosine-5-)-methyltransferase 1; AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; DNA (cytosine-5)-methyltransferase 1; m.HsaI; DNA MTase HsaI; DNA methyltransferase HsaI; CXXC-type zinc finger protein 9;
Cat.#:DNMT1-330HTag:His-Flag
Source (Host):Insect CellsSpecies:Human
Product nameRecombinant Human DNMT1 Protein, His-Flag-tagged
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Cat.#:DNMT1-1645HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DNMT1 protein, His & T7-tagged
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Cat.#:DNMT1-198HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human DNMT1 protein, MYC/DDK-tagged
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Cat.#:DNMT1-199HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DNMT1 protein, GST-tagged
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Cat.#:DNMT1-388HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human DNMT1, His-tagged
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Cat.#:DNMT1-72HTag:GST
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human DNMT1 protein, GST-tagged
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Cat.#:Dnmt1-139MTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Dnmt1
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Cat.#:DNMT1-6950MTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse DNMT1, GST-tagged
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Cat.#:DNMT1-7096CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DNMT1
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Cat.#:DNMT1-8794ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DNMT1
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Cat.#:DNMT1-511HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human DNMT1, GST-tagged
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Cat.#:Kit-1715Tag:
Source (Host):Species:
Product nameDNMT1 Chemiluminescent Assay Kit
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Involved Pathway

DNMT1 involved in several pathways and played different roles in them. We selected most pathways DNMT1 participated on our site, such as Cysteine and methionine metabolism, DNA methylation, Epigenetic regulation of gene expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with DNMT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cysteine and methionine metabolism
LDHB; DNMT3A; CTH; MAT2AL; CBSB; MDH1; CBSA; BCAT1; MDH1AA; BHMT
DNA methylation
UHRF1; DNMT3B; DNMT1; DNMT3L; DNMT3A
Epigenetic regulation of gene expression
TET1; SAP30; RRP8; PHF19; EFCAB11; JARID2B; SAP30BP; DNMT3A; DNMT3B; BAZ2A
Gene Expression
NSUN2; GTF3C4; SAP30BP; ZNF285A; SUPT16H; ESRRA; HNRNPH2; ZNF460; ZKSCAN4; AGO3B
Metabolic pathways
PGM3; ALDH9A1A.1; GGT5; PNLIP; INPP5E; DGAT1A; GMPS; GGT7; ST6GALNAC3; PLD1A
MicroRNAs in cancer
TNN; PDGFA; RDX; TRIM71; DNMT1; HDAC4; MDM4; HOXD10; ABCB1; RPS6KA5
Negative epigenetic regulation of rRNA expression
BAZ2A; SIN3B; CD3EAP; SAP30BP; DNMT1; RRP8; SAP30; TAF1C; SAP30L; TAF1B
NoRC negatively regulates rRNA expression
DNMT3B; SUDS3; CD3EAP; BAZ2A; EFCAB11; SAP130; SAP30L; SIN3B; TAF1C; TAF1D

Protein Function

DNMT1 has several biochemical functions, for example, DNA (cytosine-5-)-methyltransferase activity, DNA binding, DNA-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DNMT1 itself. We selected most functions DNMT1 had, and list some proteins which have the same functions with DNMT1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA (cytosine-5-)-methyltransferase activity
Related Protein TRDMT1; DNMT3B; DNMT1; DNMT3A
Function DNA binding
Related Protein POLR1D; HIST1H2BC; INSM1A; MYCLB; ZFP30; NR5A5; ZIC5; TNP1; FOXN2B; FOXF2
Function DNA-methyltransferase activity
Related Protein DNMT3A; TRMT10B; METTL21D; FAM86; RNMTL1B; MGMT; METTL8; DNMT3AA; PRDM12; NDUFAF5
Function RNA binding
Related Protein RPL18; ZRANB2; UPF1; APOBEC2; RBM12B1; SUZ12; AGFG1; ZMAT2; HNRNPA1; SRBD1
Function chromatin binding
Related Protein ERG; EBF2; ASF1A; NEUROD1; ZNF143; RNF20; LOXL2; PRIMPOL; PKN1; TCF7L2
Function methyl-CpG binding
Related Protein MBD1; MBD3A; ZBTB4; MBD3L1; MECP2; ZBTB33; UHRF1; MBD3; ZNF295; LRWD1
Function protein binding
Related Protein GATA6; STAP2; INPP5A; RNPS1; TRAPPC5; METTL15; RNF4; DNAJC7; WEE1; FAM54B
Function transcription factor binding
Related Protein HES3; DAXX; TCF12; SNF8; HDAC3; KAT8; AHR; ARHGEF2; ENPP2; E2F4
Function zinc ion binding
Related Protein TTC3; PHRF1; KNG1; HHIP; CYLD; DYTN; RORA; TAF15; PHC2; ZNF185

DNMT1 Related Articles

Banerjee, J; Mishra, R; et al. A reciprocal role of prostate cancer on stromal DNA damage. ONCOGENE 33:4924-4931(2014).
Yuan, LQ; Chan, GCF; et al. RANKL expression in myeloma cells is regulated by a network involving RANKL promoter methylation, DNMT1, microRNA and TNF alpha in the microenvironment. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1843:1834-1838(2014).