dnmt1
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  • Official Full Name
  • DNA (cytosine-5-)-methyltransferase 1
  • Background
  • DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
  • Synonyms
  • DNMT1; DNA (cytosine-5-)-methyltransferase 1; AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; DNA (cytosine-5)-methyltransferase 1; m.HsaI; DNA MTase HsaI; DNA methyltransferase HsaI; CXXC-type zinc finger protein 9;
Cat.#:DNMT1-330HTag:His|Flag
Source (Host):Insect CellsSpecies:Human
Product nameRecombinant Human DNMT1 Protein, His-Flag-tagged
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Cat.#:DNMT1-1645HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DNMT1 protein, His & T7-tagged
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Cat.#:DNMT1-198HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human DNMT1 protein, MYC/DDK-tagged
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Cat.#:DNMT1-199HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DNMT1 protein, GST-tagged
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Cat.#:DNMT1-388HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human DNMT1, His-tagged
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Cat.#:DNMT1-72HTag:GST
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human DNMT1 protein, GST-tagged
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Cat.#:Dnmt1-139MTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Dnmt1
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Cat.#:DNMT1-6950MTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse DNMT1, GST-tagged
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Cat.#:DNMT1-7096CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DNMT1
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Cat.#:DNMT1-8794ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DNMT1
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Cat.#:DNMT1-511HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human DNMT1, GST-tagged
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Cat.#:Kit-1715Tag:N/A
Source (Host):Species:
Product nameDNMT1 Chemiluminescent Assay Kit
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Involved Pathway

DNMT1 involved in several pathways and played different roles in them. We selected most pathways DNMT1 participated on our site, such as Cysteine and methionine metabolism, DNA methylation, Epigenetic regulation of gene expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with DNMT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cysteine and methionine metabolism
MAT2A; MDH1AA; MDH2; LDHAL6B; MRI1; ENOPH1; GCLC; CBSA; MTR; LDHB
DNA methylation
DNMT1; DNMT3B; DNMT3L; UHRF1; DNMT3A
Epigenetic regulation of gene expression
TET2; MTF2; TAF1C; TAF1D; SAP30L; SUDS3; SMARCA5; TAF1A; EFCAB11; TET1
Gene Expression
WDR77; ZNF287; POLR3H; ZNF257; TET2; MBD3; ZNF577; EEF1D; GTF3C4; TEAD3B
Metabolic pathways
Aldh1a7; GUK1B; POLR2J2; ACSM5; AGPAT9; UAP1; CRYL1; PGAM2; UQCRC2B; LTA4H
MicroRNAs in cancer
PRKCE; GRB2; ZFPM2; RHOA; APC; NOTCH3; PRKCB; SLC45A3; DICER1; DDIT4
Negative epigenetic regulation of rRNA expression
BAZ2A; SAP130; DNMT3B; SUDS3; TAF1C; DNMT1; SAP30BP; TAF1B; RRP8; SAP30L
NoRC negatively regulates rRNA expression
SAP30BP; SIN3B; TAF1A; DNMT1; SUDS3; SAP30L; TAF1B; DNMT3B; TAF1D; SAP130

Protein Function

DNMT1 has several biochemical functions, for example, DNA (cytosine-5-)-methyltransferase activity, DNA binding, DNA-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DNMT1 itself. We selected most functions DNMT1 had, and list some proteins which have the same functions with DNMT1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA (cytosine-5-)-methyltransferase activity
Related Protein DNMT1; DNMT3A; DNMT3B; TRDMT1
Function DNA binding
Related Protein ZNF521; PRM2; BHLHE22; ZNF497; TAF1A; PPARG; PRIM2; HOMEZ; ZFP184; RORCA
Function DNA-methyltransferase activity
Related Protein PRDM11; PRDM12; DNMT3B; DNMT4; PRMT8B; RNMTL1A; METTL21D; FAM86; FBLL1; TRMT10B
Function RNA binding
Related Protein ZFP346; C1D; DCP2; RBM20; ENDOU; CSTF3; KHDRBS1; HNRNPH1; PUF60B; METTL14
Function chromatin binding
Related Protein HMGB3B; POLD1; BRD2; SIN3A; NFIA; CREBBP; MSL1; MBD5; CALCOCO1; KIAA0101
Function methyl-CpG binding
Related Protein MBD3B; ZNF295; MBD3A; MBD1B; MBD1; UHRF1; MECP2; MBD3L1; ZBTB4; LRWD1
Function protein binding
Related Protein PPM1B; CCDC53; PFKFB2; SOX10; THSD4; VAPA; RTP2; SEC24A; PTRF; Tnfrsf23
Function transcription factor binding
Related Protein KEAP1; ADD1; RARA; ID1; DDIT3; HMGA1-RS1; NFKB1; PDCD11; GATA3; PPP1R13BB
Function zinc ion binding
Related Protein ZGLP1; MSRB1; ANKIB1; BRD1; ZFYVE1; ZNF385B; PRKCBB; USP49; C11orf54; PDXK

DNMT1 Related Articles

Banerjee, J; Mishra, R; et al. A reciprocal role of prostate cancer on stromal DNA damage. ONCOGENE 33:4924-4931(2014).
Yuan, LQ; Chan, GCF; et al. RANKL expression in myeloma cells is regulated by a network involving RANKL promoter methylation, DNMT1, microRNA and TNF alpha in the microenvironment. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1843:1834-1838(2014).