dpysl2
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  • Official Full Name
  • dihydropyrimidinase-like 2
  • Background
  • Collapsin Response Mediator Protein-2 (CRMP-2) is expressed at high levels in the developing nervous system and plays a critical role in axonal outgrowth by specifying axon/dendrite fate and establishing neuronal polarity. CRMP-2 enhances axon elongation
  • Synonyms
  • DPYSL2; dihydropyrimidinase-like 2; dihydropyrimidinase-related protein 2; CRMP2; DHPRP2; DRP 2; DRP2; unc-33-like phosphoprotein 2; collapsin response mediator protein hCRMP-2; N2A3; DRP-2; ULIP2; CRMP-2; ULIP-2
Cat.#:DPYSL2-1193HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human DPYSL2 Protein, His-tagged
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Cat.#:DPYSL2-2539HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human DPYSL2 Protein, MYC/DDK-tagged
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Cat.#:DPYSL2-101HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human DPYSL2, GST-tagged
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Cat.#:DPYSL2-102HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human DPYSL2, GST-tagged
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Cat.#:DPYSL2-4812MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DPYSL2 Protein
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Cat.#:DPYSL2-1949RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat DPYSL2 Protein
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Cat.#:DPYSL2-6064CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DPYSL2
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Involved Pathway

DPYSL2 involved in several pathways and played different roles in them. We selected most pathways DPYSL2 participated on our site, such as Axon guidance, BDNF signaling pathway, CRMPs in Sema3A signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with DPYSL2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
PAK3; SRGAP2; PPP3CB; CNTN6; EPHB1; EFNA3B; KCNQ3; CFL1; COL9A3; SEMA6C
BDNF signaling pathway
CDKL5; EIF2S1; DOK5; CDK5; FRS3; CNR1; FRS2; KCNN2; MAP3K2; EGR1
CRMPs in Sema3A signaling
DPYSL5A; DPYSL4; CDK5R1B; CRMP1; DPYSL2B; DPYSL3; DPYSL2; DPYSL5B; SEMA3AA; SEMA3A
Developmental Biology
DRAP1; RHOAE; CDH4; EPHA2; TRPC4; ARPC2; LGI1B; CDK5R1B; EFNA1A; DLG3
L1CAM interactions
RANBP9; DPYSL2B; NRP1A; CHL1; KIF4; DCX; SCN3A; SCN8A; KCNQ3; DLG3
Recycling pathway of L1
NADL1.1; EZRA; DPYSL2B; DPYSL2
Regulation of Microtubule Cytoskeleton
DPYSL2; CFL2; MARK2; TESK2; MAP1B; MARK1; TPPP
Semaphorin interactions
DPYSL5A; CDK5R1B; RND1L; DPYSL3; PLXND1; DPYSL5B; CRMP1; SEMA3AA; NRP1A; DPYSL2

Protein Function

DPYSL2 has several biochemical functions, for example, dihydropyrimidinase activity, microtubule binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DPYSL2 itself. We selected most functions DPYSL2 had, and list some proteins which have the same functions with DPYSL2. You can find most of the proteins on our site.
Function
Related Protein
Function dihydropyrimidinase activity
Related Protein DPYSL2; DPYS
Function microtubule binding
Related Protein KCNH2A; MTAP1A; AKAP1; KIFC3; CHP; MAPRE3B; GABARAPL2; KIF6; CETN2; POLB
Function protein binding
Related Protein KLK4; LSM5; ZNF514; RNF165; PTPRB; CUL1; PRKAA1; EDARADD; ENTPD1; FAM122A
Function protein kinase binding
Related Protein BCL2L1; GATA4; PTPRR; STXBP1; CCNL1B; SPRED1; RB1CC1; IFNAR2; ZC3HC1; SPRED2

Interacting Protein

DPYSL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DPYSL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DPYSL2.
DPYSL3; DPYSL3; DPYSL5; GORASP2; MICALL1; GRK1; DPYSL4

DPYSL2 Related Articles

Tan, F; Wahdan-Alaswad, R; et al. Dihydropyrimidinase-like protein 3 expression is negatively regulated by MYCN and associated with clinical outcome in neuroblastoma. CANCER SCIENCE 104:1586-1592(2013).