dpysl2
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  • Official Full Name
  • dihydropyrimidinase-like 2
  • Background
  • Collapsin Response Mediator Protein-2 (CRMP-2) is expressed at high levels in the developing nervous system and plays a critical role in axonal outgrowth by specifying axon/dendrite fate and establishing neuronal polarity. CRMP-2 enhances axon elongation
  • Synonyms
  • DPYSL2; dihydropyrimidinase-like 2; dihydropyrimidinase-related protein 2; CRMP2; DHPRP2; DRP 2; DRP2; unc-33-like phosphoprotein 2; collapsin response mediator protein hCRMP-2; N2A3; DRP-2; ULIP2; CRMP-2; ULIP-2
Cat.#:DPYSL2-1193HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human DPYSL2 Protein, His-tagged
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Cat.#:DPYSL2-2539HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human DPYSL2 Protein, MYC/DDK-tagged
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Cat.#:DPYSL2-101HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human DPYSL2, GST-tagged
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Cat.#:DPYSL2-102HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human DPYSL2, GST-tagged
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Cat.#:DPYSL2-4812MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DPYSL2 Protein
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Cat.#:DPYSL2-1949RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat DPYSL2 Protein
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Cat.#:DPYSL2-6064CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DPYSL2
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Involved Pathway

DPYSL2 involved in several pathways and played different roles in them. We selected most pathways DPYSL2 participated on our site, such as Axon guidance, BDNF signaling pathway, CRMPs in Sema3A signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with DPYSL2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
PAK2; SEMA3B; RAC2; MARK3; ARPC4; ACTR2; SLIT3; LOC608458; DUSP5; CLTA
BDNF signaling pathway
EIF4E; CSNK2A1P; CDH2; BCL2L11; IGF2BP1; JAK2; GNB2L1; FRS2; MAP3K2; CFL1
CRMPs in Sema3A signaling
DPYSL2; SEMA3A; CDK5; DPYSL3; DPYSL5B; DPYSL5A; CDK5R1B; DPYSL4; CRMP1; SEMA3AA
Developmental Biology
PAQR3B; CACNG2B; DUSP4; BOC; NRP1A; CSNK2A2; SCN4A; KALRNB; MED29; MARK3
L1CAM interactions
KCNQ3; EZRA; DCX; DPYSL2; SCN2B; DLG3; ANK2B; CNTN1; SCN3B; NRP1A
Recycling pathway of L1
DPYSL2; NADL1.1; DPYSL2B; EZRA
Regulation of Microtubule Cytoskeleton
CFL2; TESK2; MAP1B; TPPP; MARK1; MARK2; DPYSL2
Semaphorin interactions
CDK5R1B; SEMA3AB; RND1L; PLXNC1; SEMA4D; SEMA3A; DPYSL5B; SEMA3AA; CRMP1; NRP1A

Protein Function

DPYSL2 has several biochemical functions, for example, dihydropyrimidinase activity, microtubule binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DPYSL2 itself. We selected most functions DPYSL2 had, and list some proteins which have the same functions with DPYSL2. You can find most of the proteins on our site.
Function
Related Protein
Function dihydropyrimidinase activity
Related Protein DPYS; DPYSL2
Function microtubule binding
Related Protein SBDS; SPAG8; TRPV4; SKA2; PRC1; FES; KIF17; KIF4A; DCX; KRIT1
Function protein binding
Related Protein SETD2; CDT1; SEMA3E; MCPH1; RAB11FIP5; KIAA1958; SAMHD1; GRIP1; GLE1; SHE
Function protein kinase binding
Related Protein FAM83E; KIF13B; H2AFY; YWHAZ; DAXX; IFNAR2; CAMK2N1; PTPN23; FGF19; TRIB3

Interacting Protein

DPYSL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DPYSL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DPYSL2.
DPYSL3; DPYSL3; DPYSL5; GORASP2; MICALL1; GRK1; DPYSL4

DPYSL2 Related Articles

Tan, F; Wahdan-Alaswad, R; et al. Dihydropyrimidinase-like protein 3 expression is negatively regulated by MYCN and associated with clinical outcome in neuroblastoma. CANCER SCIENCE 104:1586-1592(2013).