Active Recombinant Full Length Human DPYSL2 Protein, C-Flag-tagged

• Cat.No.: DPYSL2-42HFL
• Product Overview: Recombinant Full Length Human DPYSL2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Bio-activity: WB positive control
• Molecular Mass: 62.1 kDa
• AA Sequence: MSYQGKKNIPRITSDRLLIKGGKIV NDDQSFYADIYMEDGLIKQIGENLI VPGGVKTIEAHSRMVIPGGI DVHTRFQMPDQGMTSADDFFQGTKA ALAGGTTMIIDHVVPEPGTSLLAAF DQWREWADSKSCCDYSLHVD ISEWHKGIQEEMEALVKDHGVNSFL VYMAFKDRFQLTDCQIYEVLSVIRD IGAIAQVHAENGDIIAEEQQ RILDLGITGPEGHVLSRPEEVEAEA VNRAITIANQTNCPLYITKVMSKSS AEVIAQARKKGTVVYGEPIT ASLGTDGSHYWSKNWAKAAAFVTSP PLSPDPTTPDFLNSLLSCGDLQVTG SAHCTFNTAQKAVGKDNFTL IPEGTNGTEERMSVIWDKAVVTGKM DENQFVAVTSTNAAKVFNLYPRKGR IAVGSDADLVIWDPDSVKTI SAKTHNSSLEYNIFEGMECRGSPLV VISQGKIVLEDGTLHVTEGSGRYIP RKPFPDFVYKRIKARSRLAE LRGVPRGLYDGPVCEVSVTPKTVTP ASSAKTSPAKQQAPPVRNLHQSGFS LSGAQIDDNIPRRTTQRIVA
  PPGGRANITSLGTRTRPLEQKLISE EDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome
• Protein Pathways: Axon guidance

Gene Information

• Gene Name: DPYSL2 dihydropyrimidinase like 2 [ Homo sapiens (human) ]
• Official Symbol: DPYSL2
• Synonyms: DRP2; N2A3; CRMP2; DRP-2; ULIP2; CRMP-2; DHPRP2; ULIP-2
• Gene ID: 1808
• mRNA Refseq: NM_001386.6
• Protein Refseq: NP_001377.1
• MIM: 602463
• UniProt ID: Q16555