F11
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Official Full Name
coagulation factor XI
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Overview
Factor XI or plasma thromboplastin antecedent is the zymogen form of factor XIa, one of the enzymes of the coagulation cascade. Like many other coagulation factors, it is a serine protease. In humans, Factor XI is encoded by the F11 gene. -
Synonyms
coagulation factor XI; F11; FXI; MGC141891; PTA; OTTHUMP00000197033; plasma thromboplastin antecedent;
- Recombinant Proteins
- Cell & Tissue Lysates
- Transfected Stable Cell Lines
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E. coli
- E.coli
- HEK293
- HEK293T
- Human Cell
- Human plasma
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- GST
- His (Fc)
- Avi
- His|GST
- His|T7
- MYC
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- F11 Related Articles
- F11 Related Gene Family
- F11 Related Research Area
F11 involved in several pathways and played different roles in them. We selected most pathways F11 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with F11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Complement and coagulation cascades | F5;BDKRB2;F3;SERPINA1D;C1RA;C8G;C9;C8A;C7 |
F11 has several biochemical functions, for example, heparin binding, protein binding, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by F11 itself. We selected most functions F11 had, and list some proteins which have the same functions with F11. You can find most of the proteins on our site.
Function | Related Protein |
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heparin binding | COL25A1;VEGFB;FGFR2;BMP7;FGF1A;WISP1A;SMOC2;UBE4A;RSPO1 |
protein binding | LRP4;SMAD4;PPP2R5B;BCL2A1;KDM4A;CXCR7;LATS2;ANKRD45;NUBP1 |
serine-type endopeptidase activity | PCSK6;IMMP2L;C1RL;TMPRSS5;MST1;PRSS41;C1S;TMPRSS11B;KLK1B9 |
F11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with F11 here. Most of them are supplied by our site. Hope this information will be useful for your research of F11.
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- Q&As
- Reviews
Q&As (6)
Ask a questionF11 plays an important role in diabetes, and abnormal levels may lead to insulin resistance and lipid metabolism disorders, which can lead to diabetes.
The mutation types of F11 include point mutations, insertions/deletions, duplications, etc., which may cause structural and functional abnormalities of the protein.
Studying the regulatory mechanism of F11 requires the comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, protein interaction, etc.
Abnormal F11 levels may indicate some diseases related to lipid metabolism, such as diabetes, obesity, hyperlipidemia, etc.
There are no drugs that directly regulate F11 levels, but they can be affected by lifestyle adjustments such as diet and exercise.
F11 has a complex relationship with other genes or proteins, and can interact with other genes or proteins and participate in a variety of biochemical reactions.
Customer Reviews (3)
Write a reviewThe structure of the recombinant protein was analyzed by nuclear magnetic resonance (NMR), X-ray crystallography or electron microscopy, and the results showed that the protein was stable.
In the process of purification, the removal of impurities is good.
There are no structural or functional defects.
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