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F11

  • Official Full Name

    coagulation factor XI

  • Overview

    Factor XI or plasma thromboplastin antecedent is the zymogen form of factor XIa, one of the enzymes of the coagulation cascade. Like many other coagulation factors, it is a serine protease. In humans, Factor XI is encoded by the F11 gene.
  • Synonyms

    coagulation factor XI; F11; FXI; MGC141891; PTA; OTTHUMP00000197033; plasma thromboplastin antecedent;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Transfected Stable Cell Lines
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Human plasma
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • MYC
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human F11-1861H Recombinant Human F11 protein, His & T7-tagged E.coli His/T7 Thr170~Glu398 (Accession # P03951)
Human F11-3602H Recombinant Human F11 Protein, GST-tagged Wheat Germ GST
Human F11-2681HCL Recombinant Human F11 cell lysate Human Cell N/A
Human F11-4476HF Recombinant Full Length Human F11 Protein, GST-tagged In Vitro Cell Free System GST 625 amino acids
Human F11-957H Recombinant Human F11 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human F11-2304H Recombinant Human F11 Protein (Thr170-Glu398), N-His tagged E.coli N-His Thr170-Glu398
Human F11-2004H Recombinant Human F11 Protein (19-387 aa), His-tagged E.coli His 19-387 aa
Human F11-4100H Recombinant Human F11 Protein (Met1-Val625), C-His tagged Mammalian cells C-His Met1-Val625
Human F11-42H Factor XI Reference standard N/A
Human F11-178H Human Blood Coagulation Factor XI Reference standard N/A
Human F11-2466H Native Human Coagulation Factor XI Human plasma N/A
Mouse F11-766M Active Recombinant Mouse F11 Protein, His-tagged Mammalian cells His Glu19-Val624
Mouse F11-5404M Recombinant Mouse F11 Protein Mammalian Cell His
Mouse F11-439M Recombinant Mouse F11 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse F11-2914M Recombinant Mouse F11 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse F11-2914M-B Recombinant Mouse F11 Protein Pre-coupled Magnetic Beads HEK293
Mouse F11-900M Recombinant Mouse F11 Protein, His-tagged E. coli His Pro157~Arg389
Rat F11-1862R Recombinant Rat F11 protein, His & GST-tagged E.coli His/GST Ile275~Gly516
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • F11 Related Articles
  • F11 Related Gene Family
  • F11 Related Research Area

F11 involved in several pathways and played different roles in them. We selected most pathways F11 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with F11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Complement and coagulation cascadesF5;BDKRB2;F3;SERPINA1D;C1RA;C8G;C9;C8A;C7

F11 has several biochemical functions, for example, heparin binding, protein binding, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by F11 itself. We selected most functions F11 had, and list some proteins which have the same functions with F11. You can find most of the proteins on our site.

Function Related Protein
heparin bindingCOL25A1;VEGFB;FGFR2;BMP7;FGF1A;WISP1A;SMOC2;UBE4A;RSPO1
protein bindingLRP4;SMAD4;PPP2R5B;BCL2A1;KDM4A;CXCR7;LATS2;ANKRD45;NUBP1
serine-type endopeptidase activityPCSK6;IMMP2L;C1RL;TMPRSS5;MST1;PRSS41;C1S;TMPRSS11B;KLK1B9

F11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with F11 here. Most of them are supplied by our site. Hope this information will be useful for your research of F11.

eco

Gonzalez-Burgos, E; Fernandez-Moriano, C; et al. Potential Neuroprotective Activity of Ginseng in Parkinson's Disease: A Review. JOURNAL OF NEUROIMMUNE PHARMACOLOGY 10:14-29(2015).
Bruzelius, M; Bottai, M; et al. Predicting venous thrombosis in women using a combination of genetic markers and clinical risk factors. JOURNAL OF THROMBOSIS AND HAEMOSTASIS 13:219-227(2015).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
Does F11 play a role in diabetes? 11/08/2022

F11 plays an important role in diabetes, and abnormal levels may lead to insulin resistance and lipid metabolism disorders, which can lead to diabetes.

What are the mutation types of F11? 04/15/2022

The mutation types of F11 include point mutations, insertions/deletions, duplications, etc., which may cause structural and functional abnormalities of the protein.

How to study the regulatory mechanism of F11? 10/27/2021

Studying the regulatory mechanism of F11 requires the comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, protein interaction, etc.

What disease might abnormal F11 levels suggest? 09/02/2021

Abnormal F11 levels may indicate some diseases related to lipid metabolism, such as diabetes, obesity, hyperlipidemia, etc.

How can the disease be treated by regulating F11 levels? 12/20/2020

There are no drugs that directly regulate F11 levels, but they can be affected by lifestyle adjustments such as diet and exercise.

What is the relationship between F11 and other genes or proteins? 08/05/2020

F11 has a complex relationship with other genes or proteins, and can interact with other genes or proteins and participate in a variety of biochemical reactions.

Customer Reviews (3)

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Reviews
11/12/2021

    The structure of the recombinant protein was analyzed by nuclear magnetic resonance (NMR), X-ray crystallography or electron microscopy, and the results showed that the protein was stable.

    05/24/2021

      In the process of purification, the removal of impurities is good.

      05/17/2021

        There are no structural or functional defects.

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