fbln1
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  • Official Full Name
  • fibulin 1
  • Background
  • Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3 end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants.
  • Synonyms
  • FBLN1; fibulin 1; fibulin-1; FBLN; Basement membrane protein 90; BM 90; FBLN1_HUMAN; FIBL 1; FIBL-1; FIBL1; OTTHUMP00000199864; OTTHUMP00000199865; OTTHUMP00000199866; OTTHUMP00000199867; OTTHUMP00000214005
Cat.#:FBLN1-3872HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FBLN1 Protein, GST-tagged
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Cat.#:FBLN1-723HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FBLN1 Protein, His-tagged
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Cat.#:Fbln1-724MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fbln1 Protein, His-tagged
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Cat.#:Fbln1-725RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Fbln1 Protein, His-tagged
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Cat.#:Fbln1-726RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Fbln1 Protein, His/GST-tagged
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Cat.#:FBLN1-12764HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FBLN1, GST-tagged
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Cat.#:FBLN1-16HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human FBLN1 protein, MYC/DDK-tagged
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Cat.#:FBLN1-28901THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human FBLN1
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Cat.#:FBLN1-28904THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human FBLN1
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Cat.#:FBLN1-5740CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FBLN1
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Cat.#:FBLN1-8670ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FBLN1
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Cat.#:FBLN1-598HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FBLN1 cell lysate
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Involved Pathway

FBLN1 involved in several pathways and played different roles in them. We selected most pathways FBLN1 participated on our site, such as Elastic fibre formation, Extracellular matrix organization, Molecules associated with elastic fibres, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBLN1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Elastic fibre formation
LTBP2; LOXL4; BMP10; ITGB3A; MFAP5; MFAP2; LOX; LOXL3; MFAP3; MFAP4
Extracellular matrix organization
EFEMP2; TLL1; COL4A4; COL8A1A; COL9A1A; DST; PCOLCE2B; CTSD; ADAMTS3; LOC100514666
Molecules associated with elastic fibres
FBLN2; LTBP4; LTBP3; MFAP2; MFAP1; MFAP3; BMP10; FBLN1; MFAP1B; MFAP5

Protein Function

FBLN1 has several biochemical functions, for example, calcium ion binding, extracellular matrix structural constituent, fibrinogen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FBLN1 itself. We selected most functions FBLN1 had, and list some proteins which have the same functions with FBLN1. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein ITSN2A; S100A10A; PVALB2; S100Z; SYT17; PCDH2AB8; ACTN1; SNED1; S100A14; EDEM1
Function extracellular matrix structural constituent
Related Protein MATN1; BGN; COL8A2; MATN3; COL27A1A; PXDN; MGP; FBN1; COL4A6; COL4A5
Function fibrinogen binding
Related Protein ITGA2B; FBLN1; MFAP2; THBS1
Function fibronectin binding
Related Protein IGFBP5A; CTSS; IGFBP5B; SDC4; CTSK; MYOC; ITGB1; MMP13; LPA; ITGB1A
Function identical protein binding
Related Protein MSTN; TARDBP; ACADM; CASC3; PLK4; CCDC91; SMAD6; THG1L; MID1; G6PD
Function integrin binding
Related Protein AMICA1; ECM2; EGFL6; TNN; DST; LAMA5; PTPN2; SEMA7A; WISP3; JAM3
Function peptidase activator activity
Related Protein FN1; PSME4; MMP25; PSME4B; PCOLCE; FBLN1; PCOLCE2; PINK1; CAV1; MMP14
Function protein C-terminus binding
Related Protein ECM1; VAMP2; BCL10; TBL1X; YEATS4; CLIC6; MPDZ; PHB; ITPR1; STIP1
Function protein binding
Related Protein CD33; PLEK; C19orf25; FOXL2; SNX3; CD247; BEND3; FAM161A; NIP7; ZNHIT3
Function protein complex binding
Related Protein PRKACA; PPP2R2A; RXRA; RPTOR; CCNE1; TMED10; C8A; RIPK1; KIF11; RNF40

Interacting Protein

FBLN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBLN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBLN1.
APOA1; SMAD3; YWHAQ; MPG; Tubb4b; CACNA1A; BHLHE40; PLSCR1; FN1; TFAP2A; SKIL; TDGF1; ATN1; SMAD4; GFI1B; EDC4

FBLN1 Related Articles

Perez-Rico, C; Pascual, G; et al. Elastin Development-Associated Extracellular Matrix Constituents of Subepithelial Connective Tissue in Human Pterygium. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 55:6309-6318(2014).
Long, KB; Artlett, CM; et al. Tight skin 2 mice exhibit a novel time line of events leading to increased extracellular matrix deposition and dermal fibrosis. MATRIX BIOLOGY 38:91-100(2014).