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FBLN1

  • Official Full Name

    fibulin 1

  • Overview

    Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3 end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants.
  • Synonyms

    FBLN1; fibulin 1; fibulin-1; FBLN; Basement membrane protein 90; BM 90; FBLN1_HUMAN; FIBL 1; FIBL-1; FIBL1; OTTHUMP00000199864; OTTHUMP00000199865; OTTHUMP00000199866; OTTHUMP00000199867; OTTHUMP00000214005;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • Flag
  • GST
  • HA
  • His
  • His|GST
  • His|Myc
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FBLN1-28901TH Recombinant Human FBLN1 Wheat Germ N/A 100 amino acids
Human FBLN1-3872H Recombinant Human FBLN1 Protein, GST-tagged Wheat Germ GST
Human FBLN1-28904TH Recombinant Human FBLN1 Wheat Germ N/A 683 amino acids
Human FBLN1-12764H Recombinant Human FBLN1, GST-tagged E.coli GST 1-300a.a.
Human FBLN1-16H Recombinant Human FBLN1 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human FBLN1-598HCL Recombinant Human FBLN1 cell lysate N/A
Human FBLN1-723H Recombinant Human FBLN1 Protein, His-tagged E.coli His Leu176~Val398
Human FBLN1-2429H Recombinant Human FBLN1 Protein (30-703 aa), His-Myc-tagged Yeast His/Myc 30-703 aa
Human FBLN1-6144H Recombinant Human FBLN1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FBLN1-1463H Recombinant Human FBLN1 Protein, His-tagged E.coli N-His Glu127-Arg241
Human FBLN1-6793HFL Recombinant Full Length Human FBLN1 protein, Flag-tagged Mamanlian cells Flag
Human FBLN1-01H Active Recombinant Human FBLN1 Protein, HA-tagged HEK293 HA
Human FBLN1-166HF Recombinant Full Length Human FBLN1 Protein In Vitro Cell Free System 683 amino acids
Human FBLN1-1464H Recombinant Human FBLN1 Protein, His-tagged E.coli N-His Asp30-Val398+LEHHHHHH
Human FBLN1-4880HF Recombinant Full Length Human FBLN1 Protein, GST-tagged In Vitro Cell Free System GST 683 amino acids
Mouse Fbln1-724M Recombinant Mouse Fbln1 Protein, His-tagged E.coli His Cys399~Arg578
Mouse Fbln1-1023M Recombinant Mouse Fbln1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat Fbln1-725R Recombinant Rat Fbln1 Protein, His-tagged E.coli His Tyr347~Asn521
Rat Fbln1-726R Recombinant Rat Fbln1 Protein, His/GST-tagged E.coli His/GST Glu127~Arg243
Zebrafish FBLN1-8670Z Recombinant Zebrafish FBLN1 Mammalian Cell His
Chicken FBLN1-5740C Recombinant Chicken FBLN1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FBLN1 Related Articles

FBLN1 involved in several pathways and played different roles in them. We selected most pathways FBLN1 participated on our site, such as Elastic fibre formation, Extracellular matrix organization, Molecules associated with elastic fibres, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBLN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Elastic fibre formationFURINA;MFAP4;ABHD1;LOXL1;BMP10;FBLN2;ITGB3A;MFAP2;MFAP5
Extracellular matrix organizationADAMTS3;LOX;PCOLCEB;MFAP2;COL9A1A;MFAP1;MFAP5;ADAMTS4;BGNA
Molecules associated with elastic fibresLTBP3;FBLN2;FBLN1;EFEMP1;MFAP3;MFAP5;MFAP1;BMP10;LTBP4

FBLN1 has several biochemical functions, for example, calcium ion binding, extracellular matrix structural constituent, fibrinogen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FBLN1 itself. We selected most functions FBLN1 had, and list some proteins which have the same functions with FBLN1. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingVSNL1;TESCB;ANXA9;NCALDB;MMP20;CAPN9;SLC25A23B;SPTA1;DNASE1L2
extracellular matrix structural constituentCOL2A1B;ELNA;COL4A1;FBLN1;COL5A1;MUC5AC;IMPG2;COL4A4;EFEMP2
fibrinogen bindingMFAP2;ITGA2B;THBS1;FBLN1
fibronectin bindingIGFBP3;ITGB1A;THBS1;IGFBP5;LRRC15;MYOC;MMP13;ITGA4;ITGB1
identical protein bindingPON2;LTBR;G6PDX;CEACAM5;CEP57L1;KHDRBS1;TTN;DYRK1A;SHANK1
integrin bindingKDR;ECM2;ANXA7;VCAM1;ADAMTS5;SEMA7A;EGFL6;VWF;ITGA6
peptidase activator activityPINK1;PCOLCE;MMP25;PSME4;MMP14;APP;CAV1;PCOLCE2;FN1
protein C-terminus bindingPICK1;SHANK3;ERCC6;ABL1;LIG4;DAB2;HAND2;DBNL;CDC20
protein bindingBLOC1S3;NEUROD1;C22orf23;ZKSCAN5;MAP4K4;SZT2;HMG20A;ELMOD3;EIF2B4
protein complex bindingEPHB1;RAN;ERCC8;AP2A1;GNB1;RAP1B;CDKN1A;NDUFA8;UQCRC1

FBLN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBLN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBLN1.

APOA1; SMAD3; YWHAQ; MPG; Tubb4b; CACNA1A; BHLHE40; PLSCR1; FN1; TFAP2A; SKIL; TDGF1; ATN1; SMAD4; GFI1B; EDC4

Perez-Rico, C; Pascual, G; et al. Elastin Development-Associated Extracellular Matrix Constituents of Subepithelial Connective Tissue in Human Pterygium. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 55:6309-6318(2014).
Long, KB; Artlett, CM; et al. Tight skin 2 mice exhibit a novel time line of events leading to increased extracellular matrix deposition and dermal fibrosis. MATRIX BIOLOGY 38:91-100(2014).
  • Q&As
  • Reviews

Q&As (5)

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Are there any therapeutic implications of FBLN1 in cardiovascular diseases? 07/26/2022

FBLN1 has been identified as a potential therapeutic target for the treatment of cardiovascular diseases due to its involvement in vascular function.

Can FBLN1 be used for genetic testing in connective tissue disorders? 05/21/2021

Genetic testing for FBLN1 mutations can be helpful in diagnosing certain connective tissue disorders.

Are there any known side effects of targeting FBLN1 for therapeutic purposes? 05/07/2021

The potential side effects of targeting FBLN1 as a therapeutic target are still under investigation and require further clinical trials.

How does FBLN1 compare to other proteins in its clinical applications? 01/17/2018

FBLN1 has distinct roles and implications in clinical applications compared to other proteins, making it an important focus of research.

How is FBLN1 related to connective tissue disorders? 08/28/2017

Mutations in the FBLN1 gene have been associated with developmental abnormalities in connective tissues, leading to connective tissue disorders such as Marfan syndrome and cutis laxa.

Customer Reviews (3)

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Reviews
06/23/2017

    This partnership enhances research productivity while ensuring accurate and meaningful outcomes.

    07/27/2016

      The manufacturer's commitment to maintaining stringent quality control measures guarantees that I can trust the protein's integrity and reliability throughout my experiments.

      02/29/2016

        Its purity and stability ensure consistent and accurate results, making it an ideal tool for my research endeavors.

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