FBLN1
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Official Full Name
fibulin 1
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Overview
Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3 end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants. -
Synonyms
FBLN1; fibulin 1; fibulin-1; FBLN; Basement membrane protein 90; BM 90; FBLN1_HUMAN; FIBL 1; FIBL-1; FIBL1; OTTHUMP00000199864; OTTHUMP00000199865; OTTHUMP00000199866; OTTHUMP00000199867; OTTHUMP00000214005;
- Recombinant Proteins
- Cell & Tissue Lysates
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- Yeast
- Flag
- GST
- HA
- His
- His|GST
- His|Myc
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | FBLN1-28901TH | Recombinant Human FBLN1 | Wheat Germ | N/A | 100 amino acids | |
Human | FBLN1-3872H | Recombinant Human FBLN1 Protein, GST-tagged | Wheat Germ | GST | ||
Human | FBLN1-28904TH | Recombinant Human FBLN1 | Wheat Germ | N/A | 683 amino acids | |
Human | FBLN1-12764H | Recombinant Human FBLN1, GST-tagged | E.coli | GST | 1-300a.a. | |
Human | FBLN1-16H | Recombinant Human FBLN1 protein, MYC/DDK-tagged | HEK293 | Myc/DDK | ||
Human | FBLN1-598HCL | Recombinant Human FBLN1 cell lysate | N/A | |||
Human | FBLN1-723H | Recombinant Human FBLN1 Protein, His-tagged | E.coli | His | Leu176~Val398 | |
Human | FBLN1-2429H | Recombinant Human FBLN1 Protein (30-703 aa), His-Myc-tagged | Yeast | His/Myc | 30-703 aa | |
Human | FBLN1-6144H | Recombinant Human FBLN1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK | ||
Human | FBLN1-1463H | Recombinant Human FBLN1 Protein, His-tagged | E.coli | N-His | Glu127-Arg241 | |
Human | FBLN1-6793HFL | Recombinant Full Length Human FBLN1 protein, Flag-tagged | Mamanlian cells | Flag | ||
Human | FBLN1-01H | Active Recombinant Human FBLN1 Protein, HA-tagged | HEK293 | HA | ||
Human | FBLN1-166HF | Recombinant Full Length Human FBLN1 Protein | In Vitro Cell Free System | 683 amino acids | ||
Human | FBLN1-1464H | Recombinant Human FBLN1 Protein, His-tagged | E.coli | N-His | Asp30-Val398+LEHHHHHH | |
Human | FBLN1-4880HF | Recombinant Full Length Human FBLN1 Protein, GST-tagged | In Vitro Cell Free System | GST | 683 amino acids | |
Mouse | Fbln1-724M | Recombinant Mouse Fbln1 Protein, His-tagged | E.coli | His | Cys399~Arg578 | |
Mouse | Fbln1-1023M | Recombinant Mouse Fbln1 Protein, MYC/DDK-tagged | HEK293T | MYC/DDK | ||
Rat | Fbln1-725R | Recombinant Rat Fbln1 Protein, His-tagged | E.coli | His | Tyr347~Asn521 | |
Rat | Fbln1-726R | Recombinant Rat Fbln1 Protein, His/GST-tagged | E.coli | His/GST | Glu127~Arg243 | |
Zebrafish | FBLN1-8670Z | Recombinant Zebrafish FBLN1 | Mammalian Cell | His | ||
Chicken | FBLN1-5740C | Recombinant Chicken FBLN1 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- FBLN1 Related Articles
FBLN1 involved in several pathways and played different roles in them. We selected most pathways FBLN1 participated on our site, such as Elastic fibre formation, Extracellular matrix organization, Molecules associated with elastic fibres, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBLN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Elastic fibre formation | FURINA;MFAP4;ABHD1;LOXL1;BMP10;FBLN2;ITGB3A;MFAP2;MFAP5 |
Extracellular matrix organization | ADAMTS3;LOX;PCOLCEB;MFAP2;COL9A1A;MFAP1;MFAP5;ADAMTS4;BGNA |
Molecules associated with elastic fibres | LTBP3;FBLN2;FBLN1;EFEMP1;MFAP3;MFAP5;MFAP1;BMP10;LTBP4 |
FBLN1 has several biochemical functions, for example, calcium ion binding, extracellular matrix structural constituent, fibrinogen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FBLN1 itself. We selected most functions FBLN1 had, and list some proteins which have the same functions with FBLN1. You can find most of the proteins on our site.
Function | Related Protein |
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calcium ion binding | VSNL1;TESCB;ANXA9;NCALDB;MMP20;CAPN9;SLC25A23B;SPTA1;DNASE1L2 |
extracellular matrix structural constituent | COL2A1B;ELNA;COL4A1;FBLN1;COL5A1;MUC5AC;IMPG2;COL4A4;EFEMP2 |
fibrinogen binding | MFAP2;ITGA2B;THBS1;FBLN1 |
fibronectin binding | IGFBP3;ITGB1A;THBS1;IGFBP5;LRRC15;MYOC;MMP13;ITGA4;ITGB1 |
identical protein binding | PON2;LTBR;G6PDX;CEACAM5;CEP57L1;KHDRBS1;TTN;DYRK1A;SHANK1 |
integrin binding | KDR;ECM2;ANXA7;VCAM1;ADAMTS5;SEMA7A;EGFL6;VWF;ITGA6 |
peptidase activator activity | PINK1;PCOLCE;MMP25;PSME4;MMP14;APP;CAV1;PCOLCE2;FN1 |
protein C-terminus binding | PICK1;SHANK3;ERCC6;ABL1;LIG4;DAB2;HAND2;DBNL;CDC20 |
protein binding | BLOC1S3;NEUROD1;C22orf23;ZKSCAN5;MAP4K4;SZT2;HMG20A;ELMOD3;EIF2B4 |
protein complex binding | EPHB1;RAN;ERCC8;AP2A1;GNB1;RAP1B;CDKN1A;NDUFA8;UQCRC1 |
FBLN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBLN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBLN1.
APOA1; SMAD3; YWHAQ; MPG; Tubb4b; CACNA1A; BHLHE40; PLSCR1; FN1; TFAP2A; SKIL; TDGF1; ATN1; SMAD4; GFI1B; EDC4
- Q&As
- Reviews
Q&As (5)
Ask a questionFBLN1 has been identified as a potential therapeutic target for the treatment of cardiovascular diseases due to its involvement in vascular function.
Genetic testing for FBLN1 mutations can be helpful in diagnosing certain connective tissue disorders.
The potential side effects of targeting FBLN1 as a therapeutic target are still under investigation and require further clinical trials.
FBLN1 has distinct roles and implications in clinical applications compared to other proteins, making it an important focus of research.
Mutations in the FBLN1 gene have been associated with developmental abnormalities in connective tissues, leading to connective tissue disorders such as Marfan syndrome and cutis laxa.
Customer Reviews (3)
Write a reviewThis partnership enhances research productivity while ensuring accurate and meaningful outcomes.
The manufacturer's commitment to maintaining stringent quality control measures guarantees that I can trust the protein's integrity and reliability throughout my experiments.
Its purity and stability ensure consistent and accurate results, making it an ideal tool for my research endeavors.
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