fbln1
Share
  • Official Full Name
  • fibulin 1
  • Background
  • Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3 end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants.
  • Synonyms
  • FBLN1; fibulin 1; fibulin-1; FBLN; Basement membrane protein 90; BM 90; FBLN1_HUMAN; FIBL 1; FIBL-1; FIBL1; OTTHUMP00000199864; OTTHUMP00000199865; OTTHUMP00000199866; OTTHUMP00000199867; OTTHUMP00000214005
Cat.#:FBLN1-2429HTag:His|Myc
Source (Host):YeastSpecies:Human
Product nameRecombinant Human FBLN1 Protein (30-703 aa), His-Myc-tagged
+Inquiry
Cat.#:FBLN1-3872HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FBLN1 Protein, GST-tagged
+Inquiry
Cat.#:FBLN1-723HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FBLN1 Protein, His-tagged
+Inquiry
Cat.#:Fbln1-724MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fbln1 Protein, His-tagged
+Inquiry
Cat.#:Fbln1-725RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Fbln1 Protein, His-tagged
+Inquiry
Cat.#:Fbln1-726RTag:His|GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Fbln1 Protein, His/GST-tagged
+Inquiry
Cat.#:FBLN1-12764HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FBLN1, GST-tagged
+Inquiry
Cat.#:FBLN1-16HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human FBLN1 protein, MYC/DDK-tagged
+Inquiry
Cat.#:FBLN1-28901THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human FBLN1
+Inquiry
Cat.#:FBLN1-28904THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human FBLN1
+Inquiry
Cat.#:FBLN1-5740CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FBLN1
+Inquiry
Cat.#:FBLN1-8670ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FBLN1
+Inquiry
Cat.#:FBLN1-598HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human FBLN1 cell lysate
+Inquiry

Involved Pathway

FBLN1 involved in several pathways and played different roles in them. We selected most pathways FBLN1 participated on our site, such as Elastic fibre formation, Extracellular matrix organization, Molecules associated with elastic fibres, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBLN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Elastic fibre formation
FBLN1; LOXL2; FBN1; FBN2; ABHD1; MFAP3; EFEMP2; FURINA; LTBP4; LTBP2
Extracellular matrix organization
ADAM9; NID1; MFAP5; TTR; COL1A1; DMP1; LOXL3; KLK7; PCOLCE2; CAPNS1
Molecules associated with elastic fibres
LTBP4; MFAP2; EFEMP2; LTBP2; EFEMP1; MFAP5; MFAP4; MFAP1; FBLN2; MFAP3

Protein Function

FBLN1 has several biochemical functions, for example, calcium ion binding, extracellular matrix structural constituent, fibrinogen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FBLN1 itself. We selected most functions FBLN1 had, and list some proteins which have the same functions with FBLN1. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein F9; LETM1; CABP5; GSNB; MYL9B; SPARC; CLSTN3; PVALB1; PRSS2; PLCB3
Function extracellular matrix structural constituent
Related Protein EFEMP2; COL3A1; MFAP5; COL1A1B; COL11A1B; CHI3L1; COL2A1B; MUC5AC; COMP; FBLN1
Function fibrinogen binding
Related Protein MFAP2; ITGA2B; THBS1; FBLN1
Function fibronectin binding
Related Protein HSD17B12; CTSL1; THBS1; CTSK; ITGAV; CCDC80; ITGB3; LPA; MFAP2; CTSS
Function identical protein binding
Related Protein POLG2; BCL2; HACL1; NCAM1; REG3B; CEACAM5; S100A1; RPE; CRYBB2; NQO1
Function integrin binding
Related Protein WISP1; ACTN4; FCER2; NISCH; SEMA7A; COL4A3; COL16A1; ILK; FN1; LAMB2
Function peptidase activator activity
Related Protein FN1; APP; CLPX; PSME4; CAV1; PINK1; MMP25; PSME4B; PCOLCE2; PCOLCE
Function protein C-terminus binding
Related Protein PPP2CA; HIC2; CALCOCO1; HESX1; MID1IP1; PRDX3; CACNA1B; VGLL2; PPM1A; CEP135
Function protein binding
Related Protein SERBP1; ALOX15; CTSL1; SIGIRR; CLINT1; MSH3; ROS1; GALR1; MAMSTR; GRID2IP
Function protein complex binding
Related Protein SKIL; PDX1; TMED10; SLC27A5; TXN2; CALY; NCK2; STRN; UFD1L; LRRC16A

Interacting Protein

FBLN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBLN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBLN1.
APOA1; SMAD3; YWHAQ; MPG; Tubb4b; CACNA1A; BHLHE40; PLSCR1; FN1; TFAP2A; SKIL; TDGF1; ATN1; SMAD4; GFI1B; EDC4

FBLN1 Related Articles

Perez-Rico, C; Pascual, G; et al. Elastin Development-Associated Extracellular Matrix Constituents of Subepithelial Connective Tissue in Human Pterygium. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 55:6309-6318(2014).
Long, KB; Artlett, CM; et al. Tight skin 2 mice exhibit a novel time line of events leading to increased extracellular matrix deposition and dermal fibrosis. MATRIX BIOLOGY 38:91-100(2014).