fcgr1a
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  • Official Full Name
  • Fc fragment of IgG, high affinity Ia, receptor (CD64)
  • Background
  • CD64 is the high-affinity IgG Fc receptor belonging to the immunoglobulin supergene family (Guyre, 2002). CD64 is a 72 kDa glycoprotein which binds monomeric IgG (human IgG1>IgG3>>IgG4>>>IgG2 and mouse IgG3>IgG2a>>>IgG1, IgG2b). Three genes: FcgammaR1A, FcgammaR1B and FcgammaR1C, which have >98 percent identity at the nucleotide level, have been identified and mapped to chromosome 1, band q21.1 (Sun,1997)). The FcgammaR1A gene, which specified the high-affinity IgG receptor, encodes three C2-type Ig-like extracellular domains, a 21 amino acid transmembrane region, and a charge cytoplasmic tail of 61 amino acids (Sun, 1997)(van de Winkel,1993).
  • Synonyms
  • FCGR1A; Fc fragment of IgG, high affinity Ia, receptor (CD64); high affinity immunoglobulin gamma Fc receptor I; Fc receptor, IgG, high affinity I; high affinity IgG Fc receptor, subunit beta; Fc fragment of IgG high affinity Ib receptor; high-affinity immunoglobulin gamma Fc receptor I; Fc fragment of IgG, high affinity Ib, receptor for (CD64); Fcgr1; Fcgr1b; FcgammaRI
Cat.#:FCGR1A-3818CTag:His-Avi
Source (Host):HEK293Species:Cynomolgus
Product nameRecombinant Cynomolgus FCGR1A protein, His-Avi-tagged, Biotinylated
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Cat.#:FCGR1A-373HTag:His & Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human FCGR1A Protein, His & Avi-tagged, Biotinylated
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Cat.#:FCGR1A-904RTag:His
Source (Host):HEK293Species:Rabbit
Product nameRecombinant Rabbit FCGR1A Protein (Met1-Phe291), His-tagged
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Cat.#:FCGR1A-3987HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FCGR1A Protein
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Cat.#:FCGR1A-3988HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FCGR1A Protein, GST-tagged
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Cat.#:FCGR1A-12818HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FCGR1A, His-tagged
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Cat.#:FCGR1A-179HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FCGR1A, His-tagged
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Cat.#:FCGR1A-180HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FCGR1A, His-tagged, Biotinylated
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Cat.#:FCGR1A-2224HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FCGR1A, His tagged
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Cat.#:FCGR1A-27573THTag:Fc
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human FCGR1A, Fc-tagged
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Cat.#:FCGR1A-3817HTag:Avi/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FCGR1A Protein, Avi/His-tagged, biotinylated
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Cat.#:FCGR1A-3818HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human Fc Fragment Of IgG, High Affinity Ia, Receptor (CD64), AVI-tagged
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Cat.#:FCGR1A-7166HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Fc Fragment Of IgG, High Affinity Ia, Receptor (CD64), His-tagged
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Cat.#:Fcgr1a-4081RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Fcgr1a, His tagged
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Cat.#:FCGR1A-1798RTag:
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey FCGR1A Protein
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Cat.#:FCGR1A-1799RTag:mIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey FCGR1A Protein, mIgG1-tagged
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Cat.#:FCGR1A-1800RTag:mIgG2a
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey FCGR1A Protein, mIgG2a-tagged
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Cat.#:FCGR1-2562HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human FCGR1 cell lysate
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Cat.#:FCGR1A-6279HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FCGR1A 293 Cell Lysate
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Cat.#:FCGR1-1972RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat FCGR1 cell lysate
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Involved Pathway

FCGR1A involved in several pathways and played different roles in them. We selected most pathways FCGR1A participated on our site, such as Phagosome, Osteoclast differentiation, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with FCGR1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Phagosome
CORO1A; COLEC12; ATP6V1C1A; HLA-DRB1; H2-AB1; CD209A; ATP6V1E2; MBL2; FCGR3A; C1R
Osteoclast differentiation
TREM2; PPP3R2; TGFBR1; SIRPA; PLCG2; AKT2; TNF; BTK; STAT1; FCGR1
Hematopoietic cell lineage
CD33; IL11RA; ITGA2; CD4; CD8B; CD1E; CD36; KIT; IL5; CD59A
Fc gamma R-mediated phagocytosis
AKT2; MARCKS; ARPC5L; VAV1; ARF6; PAK1; PRKCD; PLCG2; PIK3CD; MAPK3
Leishmaniasis
Itgam&Itgb2; RELA; ITGAM; TAB2; NCF1; H2-AB1; NOS2; TGFB1; CYBA; C3
Staphylococcus aureus infection
Hc; DSG1A; C5AR1; HLA-DRB3; DSG1C; GM5077; DSG1; PLG; C1QA; C2
Tuberculosis
RFX5; PLK3; C3; CAMK2G; MAPK11; H2-AA; IFNA1; IFNA21; IFNA17; IFNGR1
Transcriptional misregulation in cancer
RXRA; SSX1; ASPSCR1; FOXO1; SIX4; MMP9; SPINT1; FUT8; IL-8; ZBTB17
Systemic lupus erythematosus
HIST1H2BB; HIST1H3C; HIST1H2BD; ACTN2; SNRPD1; H3F3C; HIST2H2BB; GM5077; CD40; HLA-DQA1

Protein Function

FCGR1A has several biochemical functions, for example, IgG binding, protein binding, receptor signaling protein activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FCGR1A itself. We selected most functions FCGR1A had, and list some proteins which have the same functions with FCGR1A. You can find most of the proteins on our site.
Function
Related Protein
Function IgG binding
Related Protein CD247L; FCGR1; FCGR2B; FCGR3A; FCGR2C; FCER1G; FCGRT; PIP; FCGR1B; FCGR2A
Function protein binding
Related Protein CRTC1; RBL2; NATD1; TSC2; ELP4; MKKS; CLIC1; CLNS1A; PRKCI; P2RX4
Function receptor signaling protein activity
Related Protein CD3E; PLCG1; TYROBP; ADRB1; Siglece; KLK1B3; RGS14; IL1RL1; NGF; RGS12

Interacting Protein

FCGR1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FCGR1A here. Most of them are supplied by our site. Hope this information will be useful for your research of FCGR1A.
FCGR3A; SYK; hldE; CBL; SHC1; LCP2