fxyd3
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  • Official Full Name
  • FXYD domain containing ion transport regulator 3
  • Background
  • This gene belongs to a small family of FXYD-domain containing regulators of Na+/K+ ATPases which share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD, and containing 7 invariant and 6 highly conserved amino acids. This gene encodes a cell membrane protein that may regulate the function of ion-pumps and ion-channels. This gene may also play a role in tumor progression. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
  • Synonyms
  • FXYD3; FXYD domain containing ion transport regulator 3; FXYD domain containing ion transport regulator 3 , PLML; FXYD domain-containing ion transport regulator 3; MAT 8; Chloride conductance inducer protein Mat 8; Chloride conductance inducer protein Mat-8; FXYD3_HUMAN; Mammary tumor 8 kDa protein; MAT-8; MAT8; MGC111076; Phospholemman like; Phospholemman-like; PLML; phospholemman-like protein
Cat.#:FXYD3-4580HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FXYD3 Protein, GST-tagged
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Cat.#:FXYD3-13056HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FXYD3, His-tagged
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Cat.#:FXYD3-26269THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human FXYD3
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Cat.#:FXYD3-2422RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FXYD3 Protein
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Cat.#:FXYD3-6100HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FXYD3 293 Cell Lysate
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Cat.#:FXYD3-6101HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FXYD3 293 Cell Lysate
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Involved Pathway

FXYD3 involved in several pathways and played different roles in them. We selected most pathways FXYD3 participated on our site, such as Ion channel transport, Ion transport by P-type ATPases, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with FXYD3 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ion channel transport
ANO4; TRPM1B; ASPH; FKBP1B; TRPC4A; Ano3; TRPC4APA; HTR3C; TRPM1A; TRPV3
Ion transport by P-type ATPases
FXYD3; ATP11C; ATP13A1; PDZD11; FXYD6-FXYD2; CUTC; FXYD6; ATP2C2; ATP7B; ATP2C1
Transmembrane transport of small molecules
SLC16A7; SLC41A1; TRPM6; TRPM1B; ABCE1; SLC39A3; SLC9A3.1; ANKHB; SLC38A3A; SLC7A6

Protein Function

FXYD3 has several biochemical functions, for example, ATPase binding, chloride channel activity, sodium channel regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FXYD3 itself. We selected most functions FXYD3 had, and list some proteins which have the same functions with FXYD3. You can find most of the proteins on our site.
Function
Related Protein
Function ATPase binding
Related Protein SELS; TOR1AIP1; DERL1; TAF9; ESR1; NR1H2; ATP6V1E1; ATXN3; DRD1; TOR1AIP2
Function chloride channel activity
Related Protein CFTR; SLC26A5; SLC26A3.2; CLICA; GABRR1; GABRA2; BEST1; SLC26A3; SLC26A11; CLCN3
Function sodium channel regulator activity
Related Protein SCLT1; YWHAH; AGT; FXYD3; PKP2; FXYD6; NOS1; SGK2A; RANGRF; SGK2B

Interacting Protein

FXYD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FXYD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FXYD3.
CREB3; NUDT3; NR4A1; MAPK6; q5vu21_human; CREB3L1; FBXL12

FXYD3 Related Articles

Vallois, D; Niederhauser, G; et al. Gluco-Incretins Regulate Beta-Cell Glucose Competence by Epigenetic Silencing of Fxyd3 Expression (vol 9, e103277, 2014). PLOS ONE 9:-(2014).
Li, YF; Zhang, X; et al. Expression and clinical significance of FXYD3 in endometrial cancer. ONCOLOGY LETTERS 8:517-522(2014).