GABARAP Protein, GABA(A) receptor-associated protein

GABARAP

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GABARAP

Official Full Name GABA(A) receptor-associated protein
Background Gamma-aminobutyric acid A receptors (GABA(A) receptors) are ligand-gated chloride channels that mediate inhibitory;neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its;N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This;protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton.
Synonyms GABARAP; GABA(A) receptor-associated protein; gamma-aminobutyric acid receptor-associated protein; ATG8A; MM46; GABARAP-a; FLJ25768; MGC120154; MGC120155
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • Human
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MBP
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GABARAP-1010H Recombinant Human GABA(A) Receptor-associated Protein E.coli N/A
    Human GABARAP-13085H Recombinant Human GABARAP, GST-tagged E.coli GST
    Human GABARAP-26082TH Recombinant Human GABARAP, His-tagged E.coli His
    Human GABARAP-288H Recombinant Human GABARAP, His & MBP-tagged E.coli His/MBP
    Human GABARAP-4365H Recombinant Human GABA(A) receptor-associated protein, His-tagged Human His
    Human GABARAP-4622H Recombinant Human GABARAP Protein, GST-tagged Wheat Germ GST
    Human GABARAP-578H Recombinant Human GABARAP Protein, His-tagged E.coli His
    Human GABARAP-579H Recombinant Human GABARAP Protein, His-tagged Protein, Biotinylated E.coli His
    Human GABARAP-580H Recombinant Human GABARAP Protein, His-tagged Protein, Fluorescein E.coli His
    Human GABARAP-581H Recombinant Human GABARAP Protein, Agarose E.coli N/A
    Human GABARAP-582H Recombinant Human GABARAP Protein, His-tagged Protein, Rhodamine E.coli His
    Human GABARAP-703H Recombinant Human GABARAP Protein, His&MBP-tagged E.coli His/MBP
    Human GABARAP-937H Recombinant Human GABARAP Protein, GST-tagged E.coli GST
    Human GABARAP-939H Recombinant Human GABARAP Protein, His-tagged E.coli His
    Mouse GABARAP-6138M Recombinant Mouse GABARAP Protein Mammalian Cell His
    Rat GABARAP-2440R Recombinant Rat GABARAP Protein Mammalian Cell His
    Rhesus Macaque GABARAP-1786R Recombinant Rhesus monkey GABARAP Protein, His-tagged Mammalian Cell His

    GABARAP involved in several pathways and played different roles in them. We selected most pathways GABARAP participated on our site, such as Cellular responses to stress, FoxO signaling pathway, GABAergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GABARAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cellular responses to stress HIST2H3C; CABIN1; RB1CC1; LAMTOR2; RAD50; HSPA13; EGLN2; LAMTOR1; CBX8B; HIST1H1E
    FoxO signaling pathway INSRA; CCNG2; TGFBR1B; AKT3A; FOXO4; MAPK12A; GADD45AA; IGF1RA; EGFRA; GADD45B
    GABAergic synapse GNG7; GABRG3; GABRD; PRKCA; GABBR1; GNG4; GABRB3; GNAI2; SLC38A5; PRKCG
    Macroautophagy AMBRA1B; DYNLL2A; ATG7; WDR45; LC3; ATG4A; GABARAP; AMBRA1A; RB1CC1; DYNLL2B
    Regulation of autophagy ATG14; IFNA13; ATG7; INS2; BECN1; IFNA16; IFNA3; INS; ULK2; GABARAPA
    Senescence and Autophagy SLC39A2; LC3; MAP1LC3C; SLC39A3; IGFBP5; CREG1; MAP1LC3B; UVRAG; GABARAPL2; GABARAP

    GABARAP has several biochemical functions, for example, GABA receptor binding, beta-tubulin binding, microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GABARAP itself. We selected most functions GABARAP had, and list some proteins which have the same functions with GABARAP. You can find most of the proteins on our site.

    Function Related Protein
    GABA receptor binding PLCL2; GABARAPL2; GABRA5; ARFGEF2; PLCL1; GABARAPA; AKAP5; JAKMIP1; GABRG1; GABRB1
    beta-tubulin binding IFT74; NDEL1; VAPB; CCT5; HDAC6; AKAP1; TBCD; FGF13; PIFO; SERPINB1A
    microtubule binding CHP; KCNH2A; GABARAP; REEP1; PPP5C; GCAP14; MAPRE2; KATNB1; ARL3; MTAP6
    protein binding SMC6; GPR177; ARFGAP3; ZCCHC10; KTI12; PPP4R2; TMPO; SIKE1; CAMKK1; BRMS1
    ubiquitin protein ligase binding TRAF1; HDAC6; TPI1; MID1; PRKAR2B; NAE1; YOD1; NFKBIA; CUL1A; MDM2

    GABARAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GABARAP here. Most of them are supplied by our site. Hope this information will be useful for your research of GABARAP.

    SQSTM1; CALR; NBR1; ATG7

    Marcial, HS; Suga, K; et al. Molecular cloning and localization of GABA(A) receptor-associated protein in the rotifer Brachionus plicatilis. INTERNATIONAL REVIEW OF HYDROBIOLOGY 99:188-197(2014).
    Zsuzsanna, K; Patricia, P; et al. The stiff-person syndrome: a brief review and report of two cases. ORVOSI HETILAP 154:1984-1990(2013).

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