gadd45a
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  • Official Full Name
  • growth arrest and DNA-damage-inducible, alpha
  • Background
  • This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
  • Synonyms
  • GADD45A; growth arrest and DNA-damage-inducible, alpha; DDIT1; growth arrest and DNA damage-inducible protein GADD45 alpha; GADD45; DDIT-1; DNA damage-inducible transcript-1; DNA-damage-inducible transcript 1; DNA damage-inducible transcript 1 protein; gr
Cat.#:GADD45A-4657HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GADD45A Protein, GST-tagged
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Cat.#:GADD45A-941HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human GADD45A Protein, MYC/DDK-tagged
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Cat.#:GADD45A-13109HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GADD45A, GST-tagged
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Cat.#:GADD45A-26075THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GADD45A, His-tagged
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Cat.#:GADD45A-3880HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human GADD45A, His & GST tagged
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Cat.#:GADD45A-6162MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GADD45A Protein
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Cat.#:Gadd45a-1852RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Gadd45a protein, His & T7-tagged
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Cat.#:GADD45A-1798RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey GADD45A Protein, His-tagged
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Cat.#:GADD45A-3470CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GADD45A
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Cat.#:GADD45A-5195RTag:N/A
Source (Host):E. coliSpecies:Rhesus Macaque
Product nameRecombinant Rhesus Macaque Growth Arrest And DNA-damage-inducible, Alpha
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Cat.#:GADD45A-575HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human GADD45A cell lysate
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Involved Pathway

GADD45A involved in several pathways and played different roles in them. We selected most pathways GADD45A participated on our site, such as ATF-2 transcription factor network, ATM Signaling Pathway, Adipogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GADD45A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ATF-2 transcription factor network
DUSP10; ATF2; MAPK14; JUN; HRK; JUNB; CREB1; DDIT3; KCNA3; RUVBL2
ATM Signaling Pathway
GADD45A; CREB1
Adipogenesis
CDKN1A; NR2F1A; CEBPB; AGPAT2; STIL; SMAD3B; NR1H3; CTNNB1; AHR; CNTFR
Aurora A signaling
CENPA; TPX2; GADD45A; TACC1; OAZ1; AURKAIP1; TDRD7; NDEL1; AURKB; TACC3
Cell cycle
FZR1; ENSAA; DKC1; ZBTB17; CENPN; CP110; BUB1B; MCM5; DSN1; OFD1
DNA damage response
DDB2; RAD1; CDK5; GADD45G; RAD9A; HUS1B; GADD45A; RAD17; CHEK2; TLK2
Direct p53 effectors
PCBP4; TRIAP1; CCNK; EPHA2; AIFM2; DUSP1; HIC1; DGCR8; S100A2; RNF144B
FoxO family signaling
GADD45A; CSNK1G3; CSNK1G2; FBXO32; MST1; ZFAND5

Protein Function

GADD45A has several biochemical functions, for example, core promoter binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GADD45A itself. We selected most functions GADD45A had, and list some proteins which have the same functions with GADD45A. You can find most of the proteins on our site.
Function
Related Protein
Function core promoter binding
Related Protein SFPQ; KDM3A; GATA1; HDAC4; HDAC2; ELK1; CALCOCO1; IFI203; EZH2; NKX3
Function protein binding
Related Protein UPRT; ITGB1BP1; NR1I2; LIN7A; SEC22A; TRADD; CCDC93; UCHL5; Ar; CARD11

Interacting Protein

GADD45A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GADD45A here. Most of them are supplied by our site. Hope this information will be useful for your research of GADD45A.
GADD45GIP1; MAP2K6; DCTN2; TDG; NUCB2; SH3GLB1; AICDA; GADD45GIP1

GADD45A Related Articles

Addinsell, C; Walmsley, R; et al. Polyphenolic antioxidants that produce positive results in the GADD45a-GFP assay reduce levels of oxidised DNA tested using 8OxodG antibody. MUTAGENESIS 29:544-545(2014).
Dong, YL; Kabir, SM; et al. CXCR2-Driven Ovarian Cancer Progression Involves Upregulation of Proinflammatory Chemokines by Potentiating NF-kappa B Activation via EGFR-Transactivated Akt Signaling. PLOS ONE 8:-(2013).