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GADD45A

  • Official Full Name

    growth arrest and DNA-damage-inducible, alpha

  • Overview

    This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
  • Synonyms

    GADD45A; growth arrest and DNA-damage-inducible, alpha; DDIT1; growth arrest and DNA damage-inducible protein GADD45 alpha; GADD45; DDIT-1; DNA damage-inducible transcript-1; DNA-damage-inducible transcript 1; DNA damage-inducible transcript 1 protein; gr;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Rhesus Macaque
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GADD45A-3880H Recombinant Human GADD45A protein, His&GST-tagged Insect Cells His/GST Met1-Arg165
Human GADD45A-13109H Recombinant Human GADD45A, GST-tagged E.coli GST 5-165a.a.
Human GADD45A-26075TH Recombinant Human GADD45A, His-tagged E.coli His
Human GADD45A-575HCL Recombinant Human GADD45A cell lysate Insect Cell N/A
Human GADD45A-1993H Recombinant Human GADD45A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GADD45A-941H Recombinant Human GADD45A Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human GADD45A-4657H Recombinant Human GADD45A Protein, GST-tagged Wheat Germ GST
Human GADD45A-2898H Recombinant Human GADD45A Protein (Met1-Arg165), N-His tagged E.coli N-His Met1-Arg165
Human GADD45A-2936H Recombinant Human GADD45A protein, His-SUMO-tagged E.coli His-SUMO 1-165aa
Human GADD45A-3482H Recombinant Human GADD45A protein, His-tagged E.coli His 94-165 aa
Human GADD45A-5206HF Recombinant Full Length Human GADD45A Protein, GST-tagged In Vitro Cell Free System GST 165 amino acids
Mouse GADD45A-6162M Recombinant Mouse GADD45A Protein Mammalian Cell His
Mouse GADD45A-3439M Recombinant Mouse GADD45A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Gadd45a-3130M Recombinant Mouse Gadd45a Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse GADD45A-3439M-B Recombinant Mouse GADD45A Protein Pre-coupled Magnetic Beads HEK293
Rat Gadd45a-1852R Recombinant Rat Gadd45a protein, His & T7-tagged E.coli His/T7 Met1~Arg165 (Accession # P48317)
Rat Gadd45a-1558R Recombinant Rat Gadd45a Protein, His-tagged E.coli N-His Met1-Arg165
Rhesus Macaque GADD45A-1798R Recombinant Rhesus monkey GADD45A Protein, His-tagged Mammalian Cell His
Rhesus Macaque GADD45A-5195R Recombinant Rhesus Macaque Growth Arrest And DNA-damage-inducible, Alpha Rhesus Macaque N/A
Rhesus Macaque GADD45A-1619R-B Recombinant Rhesus Macaque GADD45A Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque GADD45A-1619R Recombinant Rhesus Macaque GADD45A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken GADD45A-3470C Recombinant Chicken GADD45A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GADD45A Related Articles
  • GADD45A Related Research Area
  • GADD45A Related Signal Pathway

GADD45A involved in several pathways and played different roles in them. We selected most pathways GADD45A participated on our site, such as ATF-2 transcription factor network, ATM Signaling Pathway, Adipogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GADD45A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ATF-2 transcription factor networkATF2;CBFB;JUN;JUND;HRK;KCNA3;JDP2;GADD45A;CSRP2
ATM Signaling PathwayCREB1;GADD45A
AdipogenesisRORAA;CEBPD;EGR2;DLK1;GATA2;CTNNB1;EBF1;RETN;KLF6
Aurora A signalingTACC1;NDEL1;TPX2;CENPA;AURKB;TACC3;TDRD7;GADD45A;OAZ1
Cell cycleCEP63;BABAM1;PTTG2;PHF8;RAD21;NINL;SPC24;TEX15;NEK9
DNA damage responseDDB2;CHEK2;RAD17;HUS1B;TLK2;RAD1;RAD9A;GADD45G;GADD45A
Direct p53 effectorsFOXA1;ZNF385A;CSE1L;CTSD;EDN2;S100A2;GADD45A;FDXR;DUSP1
FoxO family signalingCSNK1G2;MST1;CSNK1G3;FBXO32;GADD45A;ZFAND5

GADD45A has several biochemical functions, for example, core promoter binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GADD45A itself. We selected most functions GADD45A had, and list some proteins which have the same functions with GADD45A. You can find most of the proteins on our site.

Function Related Protein
core promoter bindingAGO1;DHX36;SPI1;IRF9;E2F1;GATA1;RBMX;XBP1;REST
protein bindingCDC14B;ZNF41;FHL5;C5orf30;VAMP7;TCEB1;UBXN8;THBS1;CA8

GADD45A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GADD45A here. Most of them are supplied by our site. Hope this information will be useful for your research of GADD45A.

GADD45GIP1; MAP2K6; DCTN2; TDG; NUCB2; SH3GLB1; AICDA; GADD45GIP1

Addinsell, C; Walmsley, R; et al. Polyphenolic antioxidants that produce positive results in the GADD45a-GFP assay reduce levels of oxidised DNA tested using 8OxodG antibody. MUTAGENESIS 29:544-545(2014).
Dong, YL; Kabir, SM; et al. CXCR2-Driven Ovarian Cancer Progression Involves Upregulation of Proinflammatory Chemokines by Potentiating NF-kappa B Activation via EGFR-Transactivated Akt Signaling. PLOS ONE 8:-(2013).
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