gapdh
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  • Official Full Name
  • glyceraldehyde-3-phosphate dehydrogenase
  • Background
  • The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The enzyme exists as a tetramer of identical chains. Many pseudogenes similar to this locus are present in the human genome.
  • Synonyms
  • GAPDH; G3PD; GAPD; MGC88685; glyceraldehyde-3-phosphate dehydrogenase; OTTHUMP00000174432; OTTHUMP00000174434; Peptidyl-cysteine S-nitrosylase GAPDH; aging-associated gene 9 protein; EC 1.2.1.12; glyceraldehyde 3-phosphate dehydrogenase; EC 2.6.99; EC 1.2.1; GAPDH (N-terminal)
Cat.#:GAPDH-517CTag:His
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken GAPDH Protein (2-333 aa), His-tagged
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Cat.#:GAPDH-9157HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GAPDH, His-tagged
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Cat.#:GAPDH-115HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Glyceraldehyde-3-phosphate dehydrogenase
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Cat.#:GAPDH-117HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human GAPDH, GST-tagged
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Cat.#:GAPDH-20HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GAPDH protein (Bioactivity Validated)
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Cat.#:GAPDH-231HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GAPDH protein, T7/His-tagged
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Cat.#:GAPDH-2519HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GAPDH, His tagged
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Cat.#:GAPDH-26354THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GAPDH
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Cat.#:Gapdh-21MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gapdh protein, His-tagged (Bioactivity Validated)
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Cat.#:Gapdh-505MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gapdh, His-tagged
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Cat.#:GAPDH-2476RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GAPDH Protein
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Cat.#:GAPDH-1812RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey GAPDH Protein, His-tagged
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Cat.#:GAPDH-5878CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GAPDH
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Cat.#:GAPDH-6540ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GAPDH
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Cat.#:GAPDH-62HTag:
Source (Host):Species:Human
Product nameNative Human Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH)
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Cat.#:GAPDH-126RTag:
Source (Host):RabbitSpecies:Rabbit
Product nameNative Rabbit GAPDH
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Cat.#:GAPDH-6024HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GAPDH 293 Cell Lysate
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Cat.#:Kit-2216Tag:
Source (Host):Species:
Product nameGAPDH Activity Assay Kit
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Involved Pathway

GAPDH involved in several pathways and played different roles in them. We selected most pathways GAPDH participated on our site, such as Glycolysis / Gluconeogenesis, Metabolic pathways, Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GAPDH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycolysis / Gluconeogenesis
HK3; G6PC2; GPI1; ADH4; HK1; LDHB; PDHA1B; FBP2; ADH6; ALDH7A1
Metabolic pathways
LDHAL6B; DTYMK; PI4K2A; TPK1; IMPA1; ATP5E; NDUFC2-KCTD14; POLR3A; SQLE; PTGDSB
Carbon metabolism
AMT; DLAT; HIBCH; HK3; ANI_1_2390104; PDHA1; PSPH; GOT1; TPI1B; TKTL1
Biosynthesis of amino acids
ACY1; GPT; CTH; PFKMB; NAGS; GOT2A; GOT2; CBS; CBSA; TAT
HIF- signaling pathway
MAP2K1; AKT1; PFKL; PDK1; EIF4E1B; PIK3R3; PIK3R1; GM5506; EGLN1; PDHA2
Alzheimers disease
EIF2AK3; COX8C; FADD; LRP1; NDUFB11; CASP9; APAF1; NDUFA7; ERN1; PLCB1

Protein Function

GAPDH has several biochemical functions, for example, NAD binding, NADP binding, glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GAPDH itself. We selected most functions GAPDH had, and list some proteins which have the same functions with GAPDH. You can find most of the proteins on our site.
Function
Related Protein
Function NAD binding
Related Protein AOX3L1; PARP1; ADH1; HSD11B2; GRHPRA; HSD3B5; BDH2; AOX4; IDH3G; UGDH
Function NADP binding
Related Protein DHFRL1; FMO3; DPYD; MIOX; MTHFR; GAPDH; MTRR; G6PD; ASPDH; NOS3
Function glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Related Protein GAPDH; GAPDHS
Function identical protein binding
Related Protein KCTD17; CLDN11; PSME3; STAT2; ALDOA; UBQLN1; RCAN1; P2RX2; KCNJ2; CLDND
Function microtubule binding
Related Protein SKA1; MAP205; TRAF3IP1; CHP1; DNM2; DYNC1I1; VAPB; DPYSL2; SBDS; KIF3A
Function peptidyl-cysteine S-nitrosylase activity
Related Protein GAPDH
Function protein binding
Related Protein PPIF; WDYHV1; Apba1; MRE11A; PDCD6; KHK; SNTB2; CDC73; FCRL4; PFTK1

Interacting Protein

GAPDH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GAPDH here. Most of them are supplied by our site. Hope this information will be useful for your research of GAPDH.
EGFR; S100A8; PREP; PCNA

GAPDH Related Articles

Bil-Lula, I; Sochocka, M; et al. Adenovirus Type 9 Enhances Differentiation and Decreases Cytokine Release from Preadipocytes. JOURNAL OF MEDICAL VIROLOGY 87:230-239(2015).
Upadhyaya, B; Tian, XL; et al. Expression and distribution of thiol-regulating enzyme glutaredoxin 2 (GRX2) in porcine ocular tissues. EXPERIMENTAL EYE RESEARCH 130:58-65(2015).