gcnt2
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  • Official Full Name
  • glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
  • Background
  • This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described.
  • Synonyms
  • GCNT2; glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group); cataract, congenital , CCAT, GCNT5, glucosaminyl (N acetyl) transferase 2, I branching enzyme , glucosaminyl (N acetyl) transferase 2, I branching enzyme (Ii blood group) , glucosaminyl (N acetyl) transferase 5 , II, NACGT1; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase; bA360O19.2; bA421M1.1; IGNT; Ii blood group; NAGCT1; ULG3; unassigned linkage group 3; Beta 1 6 N acetylglucosaminyltransferase 2; CCAT; GCNT 2; GCNT2C; GCNT5; Glucosaminyl (N acetyl) transferase 2 I branching enzyme (I blood group); Glucosaminyl (N acetyl) transferase 2 I branching enzyme; I beta 1 6 N acetylglucosaminyltransferase; I branching beta 1 6 acetylglucosaminyltransferase; I branching enzyme; II; MGC163396; N acetylglucosaminyltransferase; N acetyllactosaminide beta 1 6 N acetylglucosaminyltransferase; NACGT1; I-branching enzyme; OTTHUMP00000016015; OTTHUMP00000016018; OTTHUMP00000016021; N-acetylglucosaminyltransferase; I beta-1,6-N-acetylglucosaminyltransferase; beta-1,6-N-acetylglucosaminyltransferase 2; I-branching beta-1,6-acetylglucosaminyltransferase; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase
Cat.#:GCNT2-4805HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GCNT2 Protein, GST-tagged
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Cat.#:GCNT2-667HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human GCNT2 Protein, MYC/DDK-tagged
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Cat.#:GCNT2-89HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human GCNT2, His-tagged
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Cat.#:GCNT2-5979HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GCNT2 293 Cell Lysate
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Involved Pathway

GCNT2 involved in several pathways and played different roles in them. We selected most pathways GCNT2 participated on our site, such as Glycosphingolipid biosynthesis - lacto and neolacto series, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GCNT2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycosphingolipid biosynthesis - lacto and neolacto series
B3GNT1; ST3GAL3; ST3GAL6; FUT4; B3GALT2; GCNT2; FUT9; ST8SIA1; B3GALT5; B3GALT1
Metabolic pathways
B3GALT6; AANAT; UQCRC2B; COX5A; CYP2P9; MAN2A2; EXTL2; MECR; POLA2; GALNT3

Protein Function

GCNT2 has several biochemical functions, for example, N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity, N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GCNT2 itself. We selected most functions GCNT2 had, and list some proteins which have the same functions with GCNT2. You can find most of the proteins on our site.
Function
Related Protein
Function N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity
Related Protein B3GNT1; GCNT2; B3GNT3; B3GNT4; B3GNT2
Function N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity
Related Protein GCNT2; GCNT4; GCNT3

GCNT2 Related Articles

Nonaka, M; Fukuda, MN; et al. Determination of Carbohydrate Structure Recognized by Prostate-specific F77 Monoclonal Antibody through Expression Analysis of Glycosyltransferase Genes. JOURNAL OF BIOLOGICAL CHEMISTRY 289:16478-16486(2014).
Henion, TR; Schwarting, GA; et al. N-Linked Polylactosamine Glycan Synthesis Is Regulated by Co-Expression of beta 3GnT2 and GCNT2. JOURNAL OF CELLULAR PHYSIOLOGY 229:471-478(2014).