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GCNT2

Official Full Name

glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
Overview

This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described.
Synonyms

GCNT2; glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group); cataract, congenital , CCAT, GCNT5, glucosaminyl (N acetyl) transferase 2, I branching enzyme , glucosaminyl (N acetyl) transferase 2, I branching enzyme (Ii blood group) , glucosaminyl (N acetyl) transferase 5 , II, NACGT1; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase; bA360O19.2; bA421M1.1; IGNT; Ii blood group; NAGCT1; ULG3; unassigned linkage group 3; Beta 1 6 N acetylglucosaminyltransferase 2; CCAT; GCNT 2; GCNT2C; GCNT5; Glucosaminyl (N acetyl) transferase 2 I branching enzyme (I blood group); Glucosaminyl (N acetyl) transferase 2 I branching enzyme; I beta 1 6 N acetylglucosaminyltransferase; I branching beta 1 6 acetylglucosaminyltransferase; I branching enzyme; II; MGC163396; N acetylglucosaminyltransferase; N acetyllactosaminide beta 1 6 N acetylglucosaminyltransferase; NACGT1; I-branching enzyme; OTTHUMP00000016015; OTTHUMP00000016018; OTTHUMP00000016021; N-acetylglucosaminyltransferase; I beta-1,6-N-acetylglucosaminyltransferase; beta-1,6-N-acetylglucosaminyltransferase 2; I-branching beta-1,6-acetylglucosaminyltransferase; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Mouse
Mus musculus (Mouse)

Source

CHO
E.coli expression system
HEK293
HEK293T
In Vitro Cell Free System
Wheat Germ

Tag

GST
His
Myc
DDK
Myc|DDK
N/A
N
6×His, GFP

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GCNT2-01H	Active Recombinant Human GCNT2 protein, His-tagged	CHO	His		Inquiry
Human	GCNT2-89H	Recombinant Human GCNT2, His-tagged	HEK293	His		Inquiry
Human	GCNT2-667H	Recombinant Human GCNT2 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	GCNT2-5979HCL	Recombinant Human GCNT2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	GCNT2-5186HF	Recombinant Full Length Human GCNT2 Protein, GST-tagged	In Vitro Cell Free System	GST	402 amino acids	Inquiry
Human	GCNT2-4805H	Recombinant Human GCNT2 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	GCNT2-10H	Active Recombinant Human GCNT2 Protein (AA 26-400), N-6×His/GFP tagged	HEK293	N-6×His, GFP	AA 26-400	Inquiry
Mouse	Gcnt2-3176M	Recombinant Mouse Gcnt2 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mus musculus (Mouse)	RFL3098MF	Recombinant Full Length Mouse N-Acetyllactosaminide Beta-1,6-N-Acetylglucosaminyl-Transferase(Gcnt2) Protein, His-Tagged	E.coli expression system	His	Full Length (1-401)	Inquiry

Involved Pathway
Protein Function
Interacting Protein
GCNT2 Related Articles

GCNT2 involved in several pathways and played different roles in them. We selected most pathways GCNT2 participated on our site, such as Glycosphingolipid biosynthesis - lacto and neolacto series, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GCNT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Glycosphingolipid biosynthesis - lacto and neolacto series	B3GNT2;B4GALT1;FUT7;ST3GAL3;FUT2;FUT9;FUT4;GCNT2;B3GNT4
Metabolic pathways	GLCE;COX7C;BCKDHA;COX8C;NMNAT2;GALNTL2;CYP2U1;INPP5B;POLR2B

GCNT2 has several biochemical functions, for example, N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity, N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GCNT2 itself. We selected most functions GCNT2 had, and list some proteins which have the same functions with GCNT2. You can find most of the proteins on our site.

Function	Related Protein
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity	B3GNT2;B3GNT1;GCNT2;B3GNT3;B3GNT4
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity	GCNT2;GCNT4;GCNT3

GCNT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GCNT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GCNT2.

Nonaka, M; Fukuda, MN; et al. Determination of Carbohydrate Structure Recognized by Prostate-specific F77 Monoclonal Antibody through Expression Analysis of Glycosyltransferase Genes. JOURNAL OF BIOLOGICAL CHEMISTRY 289:16478-16486(2014).

Henion, TR; Schwarting, GA; et al. N-Linked Polylactosamine Glycan Synthesis Is Regulated by Co-Expression of beta 3GnT2 and GCNT2. JOURNAL OF CELLULAR PHYSIOLOGY 229:471-478(2014).