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GDF5

  • Official Full Name

    growth differentiation factor 5

  • Overview

    The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development.
  • Synonyms

    GDF5; growth differentiation factor 5; growth/differentiation factor 5; BMP14; cartilage derived morphogenetic protein 1; CDMP1; GDF-5; CDMP-1; radotermin; cartilage-derived morphogenetic protein-1; OS5; LAP4; SYNS2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E. coli
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • His(C
  • ter)
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GDF5-34H Recombinant Human GDF5 protein E.coli N/A 120
Human GDF5-27470TH Recombinant Human GDF5 E.coli N/A
Human GDF5-27678TH Recombinant Human GDF5, His-tagged E.coli His
Human GDF5-13211H Recombinant Human GDF5, GST-tagged E.coli GST 143-501a.a.
Human GDF-5300H Recombinant Human Growth Differentiation Factor 5, His-tagged E.coli His
Human GDF5-5968HCL Recombinant Human GDF5 293 Cell Lysate HEK293 N/A
Human GDF5-107H Active Recombinant Human GDF5 Protein E.coli
Human GDF5-4827H Recombinant Human GDF5 Protein, GST-tagged Wheat Germ GST
Human GDF5-275H Recombinant Human GDF5 Protein, His-tagged E.coli His Leu86~Arg501
Human GDF5-299H Active Recombinant Human GDF5 Protein (Ala382-Arg501), C-His tagged, Animal-free, Carrier-free E.coli C-His Ala382-Arg501
Human GDF5-2449H Recombinant Human GDF5 Protein (Ala382-Arg501), His tagged E.coli His Ala382-Arg501
Human GDF5-049H Active Recombinant Human GDF5 Protein E. coli
Human GDF5-105H Recombinant Active Human Gdf5 Protein, His-tagged(C-ter) E.coli His(C-ter)
Mouse Gdf5-720M Active Recombinant Mouse Growth Differentiation Factor 5 E.coli N/A
Mouse Gdf5-512M Recombinant Mouse Gdf5 protein, His-tagged E.coli His
Mouse GDF5-6288M Recombinant Mouse GDF5 Protein Mammalian Cell His
Mouse Gdf5-651M Recombinant Mouse Gdf5 protein E.coli N/A 120
Mouse GDF5-3521M Recombinant Mouse GDF5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GDF5-3521M-B Recombinant Mouse GDF5 Protein Pre-coupled Magnetic Beads HEK293
Mouse Gdf5-7211M Recombinant Mouse Gdf5 Protein, His-tagged E.coli His 376-495
Mouse Gdf5-276M Recombinant Mouse Gdf5 Protein, His-tagged E.coli His Gln358~Arg495
Mouse Gdf5-065M Active Recombinant Mouse Gdf5 Protein E.coli
Rat GDF5-320R Recombinant Rat GDF5, His-tagged E. coli His Gln358~Arg495
Chicken GDF5-5910C Recombinant Chicken GDF5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GDF5 Related Articles
  • GDF5 Related Gene Family
  • GDF5 Related Research Area

GDF5 involved in several pathways and played different roles in them. We selected most pathways GDF5 participated on our site, such as Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GDF5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionCXCR3;IFNA16;Il23a; Il12b;CXCL6;GM13306;CCL2;PRLR;Cxcl15;CCL20
TGF-beta signaling pathwayTGFB2;BMPR1BB;BMPR2B;LEFTY1;BMP7;ACVR2B;TGFB1;BMP7B;BMPR1B
Hippo signaling pathwayGDF7;INADL;SERPINE1;WNT16;FZD8;FZD3;SMAD1;WNT9B;TEAD3

GDF5 has several biochemical functions, for example, BMP binding, cytokine activity, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GDF5 itself. We selected most functions GDF5 had, and list some proteins which have the same functions with GDF5. You can find most of the proteins on our site.

Function Related Protein
BMP bindingHFE2;BMPR2;GDF5;NBL1;CER1;GREM1;GREM2;TCAP
cytokine activityIFNK;TNFSF13;FGF2;IL17F;IFNA16;BMP2;IL13;HMGB1;INHBA
growth factor activityFIGF;SPAW;FGF7;FGF4;FGF24;TGFB3;NUDT6;JAG2;GDF6B
identical protein bindingMNS1;C1QL2;LUC7L;CASP6;APPL1;TP53;AXIN1;TMEM115;FGFR1
protein bindingGNAI1;RPS7;PDHB;FRS2;GPX3;EXOC1;LAMA1;SLMAP;TDP2
transforming growth factor beta receptor bindingGDF5;TGFB2;GDF7;BMP8B;BMP7B;GDF15;SMURF2;LFT1;SMAD3

GDF5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GDF5 here. Most of them are supplied by our site. Hope this information will be useful for your research of GDF5.

BMPR1B; BMPR1A; NOG; BMPR2

Degenkolbe, E; Schwarz, C; et al. Improved bone defect healing by a superagonistic GDF5 variant derived from a patient with multiple synostoses syndrome. BONE 73:111-119(2015).
Yamashita, A; Morioka, M; et al. Generation of Scaffoldless Hyaline Cartilaginous Tissue from Human iPSCs. STEM CELL REPORTS 4:404-418(2015).
TGF
  • Q&As
  • Reviews

Q&As (5)

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How does GDF5 contribute to cartilage repair? 10/10/2022

GDF5 has been found to stimulate the proliferation and differentiation of chondrocytes, the cells responsible for cartilage formation and maintenance.

What preclinical evidence supports the use of GDF5 in orthopedics? 01/16/2021

Preclinical studies have demonstrated GDF5's ability to promote bone and cartilage regeneration in animal models, providing a foundation for further clinical exploration.

How does GDF5 differ from other growth factors in terms of clinical applications? 10/01/2017

GDF5's specificity for bone and cartilage development distinguishes it from other growth factors, making it a targeted option for orthopedic interventions.

Can GDF5 be used in combination with other therapies for enhanced effects? 09/06/2017

Some studies suggest that combining GDF5 with other growth factors or therapeutic approaches may result in synergistic effects, improving overall outcomes.

Is GDF5 only relevant for bone and cartilage conditions, or are there other potential applications? 08/18/2017

While its primary focus is on musculoskeletal conditions, GDF5's role in cellular differentiation opens avenues for exploring its applications in broader regenerative medicine contexts.

Customer Reviews (3)

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Reviews
06/26/2022

    Their dedicated team of experts is prompt, knowledgeable, and readily available to tackle any hurdles or concerns I may encounter.

    03/20/2020

      Used in protein electron microscopy structure analysis.Great.

      08/31/2019

        By harnessing the power of the GDF5 protein, I can harness its outstanding quality and tap into its potential to obtain dependable and meaningful findings.

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