|Official Full Name||growth differentiation factor 5|
|Background||The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development.|
|Synonyms||GDF5; growth differentiation factor 5; growth/differentiation factor 5; BMP14; cartilage derived morphogenetic protein 1; CDMP1; GDF-5; CDMP-1; radotermin; cartilage-derived morphogenetic protein-1; OS5; LAP4; SYNS2|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
GDF5 involved in several pathways and played different roles in them. We selected most pathways GDF5 participated on our site, such as Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GDF5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Cytokine-cytokine receptor interaction||GHR; TGFB1; TNFRSF10C; IFNA14; PDGFA; IL10RA; IFNAR2; EGFRA; GM2002; CCL18|
|TGF-beta signaling pathway||NBL1; SMAD4; BMP5; ACVR1; SP1; BMP8B; SMAD5; RBX1; MAPK1; CHD|
|Hippo signaling pathway||PPP2CB; ACTB; TGFB3; CTNNA2; SMAD7; FZD2; CTGF; BMPR2; PRKCI; WNT8B|
GDF5 has several biochemical functions, for example, BMP binding, cytokine activity, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GDF5 itself. We selected most functions GDF5 had, and list some proteins which have the same functions with GDF5. You can find most of the proteins on our site.
|BMP binding||GREM1; HFE2; GDF5; NBL1; TCAP; BMPR2; GREM2; CER1|
|cytokine activity||GDF2; IL23; CCL38.1; TNF; BMP8A; TNFSF13B; PRL7D1; OSM; BMP2B; GPR19|
|growth factor activity||PRL2C3; IGF2; NDR1; TGFA; IGF2B; HDGF; PDGFC; FGF1A; BTC; FGF11A|
|identical protein binding||RASSF1; MBIP; C1QTNF6; FTL; CHEK2; GCG; LDHB; ATL1; NDE1; CDC42BPA|
|protein binding||ACCS; PDCL; AK3; MCRS1; CACYBP; GNS; C19orf57; BRCC3; GBP2; PTPRB|
|transforming growth factor beta receptor binding||INHBB; INHBC; GDF6B; BMP10; GDF7; BMP15; USP15; FKBP1A; INHA; BMP4|
GDF5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GDF5 here. Most of them are supplied by our site. Hope this information will be useful for your research of GDF5.
BMPR1B; BMPR1A; NOG; BMPR2