gdf6
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  • Official Full Name
  • growth differentiation factor 6
  • Background
  • This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily of secreted signaling molecules. It is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), which is a congenital disorder of spinal segmentation.
  • Synonyms
  • GDF6; growth differentiation factor 6; growth/differentiation factor 6; BMP13; GDF-6; Klippel-Feil syndrome; Klip-Feil malformation; Klippel-Feil malformation; growth/differentiation factor 16; KFM; KFS; KFS1; KFSL; SGM1; CDMP2; MCOP4; SCDO4; MCOPCB6; MGC
Cat.#:GDF6-277HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GDF6 Protein, His-tagged
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Cat.#:Gdf6-278MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gdf6 Protein, His-tagged
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Cat.#:GDF6-381HTag:N/A
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human GDF6 protein
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Cat.#:GDF6-517HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human GDF6
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Cat.#:GDF6-2503RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GDF6 Protein
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Cat.#:Gdf6-722MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Growth Differentiation Factor 6
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Cat.#:GDF6-19HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Growth Differentiation Factor 6
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Cat.#:GDF6-5967HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human GDF6 293 Cell Lysate
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Involved Pathway

GDF6 involved in several pathways and played different roles in them. We selected most pathways GDF6 participated on our site, such as TGF-beta signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GDF6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
TGF-beta signaling pathway
EP300; SMURF1; PITX2; BMPR1B; TFDP1A; E2F5; RBL1; CUL1; RHOA; INHBC
Hippo signaling pathway
YWHAG; PPP2R2D; FZD1; BMP4; YWHAZ; BMPR1B; GDF5; PRKCZ; SMAD3; TGFB1

Protein Function

GDF6 has several biochemical functions, for example, cytokine activity, growth factor activity, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GDF6 itself. We selected most functions GDF6 had, and list some proteins which have the same functions with GDF6. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein IL23; IL18; IL1A; IL17A/F1; IL28A; IL11; Fasl; IFNA1; NDP; Il2
Function growth factor activity
Related Protein IL8L2; HBEGF; KITLG; INHBB; FGF21; JAG1; GDF1; CDNF; INHA; FGF13
Function protein homodimerization activity
Related Protein GRHPR; SMAD1; ADD1; GRPEL2; BARD1; ANG; ABCD2; RBM44; IMPA2; ANXA1
Function transforming growth factor beta receptor binding
Related Protein BMP7B; BMP4; GDF5; GDF15; SPAW; INHBAB; FKBP1A; LFT2; BMP8B; LEFTY1

GDF6 Related Articles

Wendroth, SM; Mentrikoski, MJ; et al. GATA3 expression in morphologic subtypes of breast carcinoma: a comparison with gross cystic disease fluid protein 15 and mammaglobin. ANNALS OF DIAGNOSTIC PATHOLOGY 19:6-9(2015).
Esser, JS; Rahner, S; et al. Fibroblast Growth Factor Signaling Pathway in Endothelial Cells Is Activated by BMPER to Promote Angiogenesis. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 35:358-367(2015).

GDF6 Related Gene Family

TGF