glrx2
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  • Official Full Name
  • glutaredoxin 2
  • Background
  • The protein encoded by this gene is a member of the glutaredoxin family of proteins, which maintain cellular thiol homeostasis. These proteins are thiol-disulfide oxidoreductases that use a glutathione-binding site and one or two active cysteines in their active site. This gene undergoes alternative splicing to produce multiple isoforms, one of which is ubiquitously expressed and localizes to mitochondria, where it functions in mitochondrial redox homeostasis and is important for the protection against and recovery from oxidative stress. Other isoforms, which have more restrictive expression patterns, show cytosolic and nuclear localization, and are thought to function in cellular differentiation and transformation, possibly with a role in tumor progression. GRX1 has a glutathione-disulfide oxidoreductase activity in the presence of nadph and glutathione reductase. reduces low molecular weight disulfides and proteins. Glutaredoxin is a glutathione (GSH)-dependent hydrogen donor for ribonucleotide reductase and also catalyzes glutathione-disulfide oxidoreduction reactions in the presence of NADPH and glutathione reductase. GRX1 is multifunctional enzyme with glutathione-dependent oxidoreductase, glutathione peroxidase and glutathione S-transferase (GST) activity. The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing cytosolic protein- and non-protein-disulfides in a coupled system with glutathione reductase. Required for resistance to reactive oxygen species (ROS) by directly reducing hydroperoxides and for the detoxification of ROS-mediated damage.
  • Synonyms
  • GLRX2; glutaredoxin 2; bA101E13.1; bA101E13.1 (GRX2 glutaredoxin (thioltransferase) 2); GRX2; mitochondrial; CGI133; GLRX2_HUMAN; Glutaredoxin-2; OTTHUMP00000033766; OTTHUMP00000033767; CGI-133; TTR1; Cytoplasmic glutaredoxin, thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; YDR513W
Cat.#:GLRX2-4976HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GLRX2 Protein, GST-tagged
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Cat.#:GLRX2-13312HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GLRX2, GST-tagged
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Cat.#:GLRX2-19HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GLRX2 protein
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Cat.#:GLRX2-27693THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GLRX2
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Cat.#:GLRX2-27694THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GLRX2, His-tagged
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Cat.#:GLRX2-2571RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GLRX2 Protein
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Cat.#:GLRX2-550CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus GLRX2 Protein, His-tagged
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Cat.#:GLRX2-1875RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey GLRX2 Protein, His-tagged
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Cat.#:GLRX2-541ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GLRX2
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Cat.#:GLRX2-1828HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Glutaredoxin 2, His-tagged
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Cat.#:GRX2-76YTag:His
Source (Host):E. coliSpecies:Yeast
Product nameRecombinant Yeast Glutaredoxin 2, His-tagged
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Cat.#:GLRX2-714HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GLRX2 cell lysate
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Protein Function

GLRX2 has several biochemical functions, for example, 2 iron, 2 sulfur cluster binding, arsenate reductase (glutaredoxin) activity, electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GLRX2 itself. We selected most functions GLRX2 had, and list some proteins which have the same functions with GLRX2. You can find most of the proteins on our site.
Function
Related Protein
Function 2 iron, 2 sulfur cluster binding
Related Protein FDX1L; GLRX2; FECH; ISCA1; ISCA2; SDHB; NDUFS1; CISD3; RFESD; CIAPIN1
Function arsenate reductase (glutaredoxin) activity
Related Protein GLRX2
Function electron carrier activity
Related Protein GRXCR1; XDH; COX7A1; AKR7A3; ETFDH; AOX3; NDUFV2; AOX4; GCDHB; COX5A
Function glutathione disulfide oxidoreductase activity
Related Protein GLRX; GLRX2
Function metal ion binding
Related Protein BRD1B; LHX1A; CYP2AD6; TNFRSF11A; ADPRM; ABLIM1A; ISL2A; ZC3H15; AGBL1; CYP2J6
Function protein disulfide isomerase activity
Related Protein TXNDC5; PDIA2; QSOX1; QSOX2; TXNDC11; PDIA3; PDILT; ITGB3; ERO1L; TMX3
Function protein disulfide oxidoreductase activity
Related Protein CHCHD4; TXN; TXNRD3; SH3BGRL3; TXN2; ERO1LB; CCS; GLRX3; TXNRD1; GLRX2

GLRX2 Related Articles

Upadhyaya, B; Tian, XL; et al. Expression and distribution of thiol-regulating enzyme glutaredoxin 2 (GRX2) in porcine ocular tissues. EXPERIMENTAL EYE RESEARCH 130:58-65(2015).
Zhang, J; Yan, H; et al. Ultraviolet Radiation-Induced Cataract in Mice: The Effect of Age and the Potential Biochemical Mechanism. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 53:7276-7285(2012).