gm2a
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  • Official Full Name
  • GM2 ganglioside activator
  • Background
  • This gene encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease. Alternative splicing results in multiple transcript variants.
  • Synonyms
  • GM2A; GM2 ganglioside activator; GM2 ganglioside activator protein; ganglioside GM2 activator; cerebroside sulfate activator protein; SAP 3; sphingolipid activator protein 3; Ganglioside GM2 activator isoform short; Ganglioside GM2 activator precursor; GM2 AP; GM2-AP; GM2AP; OTTHUMP00000160619; SAP-3; SAP3; SAP3_HUMAN; Shingolipid activator protein 3
Cat.#:GM2A-5001HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GM2A Protein, GST-tagged
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Cat.#:GM2A-27454THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human GM2A
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Cat.#:GM2A-27456THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human GM2A
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Cat.#:GM2A-521HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human GM2A Protein, His-tagged
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Cat.#:GM2A-556HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GM2A protein, His-tagged
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Cat.#:GM2A-554CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus GM2A Protein, His-tagged
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Cat.#:GM2A-2558ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GM2A
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Cat.#:GM2A-450HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human GM2A cell lysate
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Involved Pathway

GM2A involved in several pathways and played different roles in them. We selected most pathways GM2A participated on our site, such as Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with GM2A were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Lysosome
NEU1; ASAH1A; CTSE; PSAPL1; GGA1; GNSB; MAN2B1; GNPTAB; CTSC; SGSH

Protein Function

GM2A has several biochemical functions, for example, beta-N-acetylgalactosaminidase activity, lipid transporter activity, phospholipase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GM2A itself. We selected most functions GM2A had, and list some proteins which have the same functions with GM2A. You can find most of the proteins on our site.
Function
Related Protein
Function beta-N-acetylgalactosaminidase activity
Related Protein GM2A
Function lipid transporter activity
Related Protein VTG2; VTG7; APOA2; APOA1A; SLCO2A1; APOL3; APOBB.1; APOF; APOC4; VTG1
Function phospholipase activator activity
Related Protein CCL5; PDPK1; GM2A; ARHGAP6; CCL3; CCL8; APOC2

Interacting Protein

GM2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GM2A here. Most of them are supplied by our site. Hope this information will be useful for your research of GM2A.
pi3p; GABARAPL2

GM2A Related Articles

Molnar, J; Nagy, T; et al. Genome sequencing and analysis of Mangalica, a fatty local pig of Hungary. BMC GENOMICS 15:-(2014).
Sinici, I; Yonekawa, S; et al. In Cellulo Examination of a Beta-Alpha Hybrid Construct of Beta-Hexosaminidase A Subunits, Reported to Interact with the GM2 Activator Protein and Hydrolyze GM2 Ganglioside. PLOS ONE 8:-(2013).