gsn
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  • Official Full Name
  • gelsolin
  • Background
  • The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • GSN; gelsolin; ADF; AGEL; brevin; actin-depolymerizing factor;
Cat.#:GSN-4401HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GSN Protein, GST-tagged
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Cat.#:GSN-13563HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSN, GST-tagged
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Cat.#:GSN-201HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSN protein, T7/His-tagged
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Cat.#:GSN-29012THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human GSN
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Cat.#:GSN-29014THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human GSN
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Cat.#:GSN-528HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSN Protein, His/GST-tagged
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Cat.#:GSN-529HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSN Protein, His-tagged
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Cat.#:GSN-530HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSN Protein, His/GST-tagged
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Cat.#:GSN-531HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSN Protein, His-tagged
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Cat.#:Gsn-532MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gsn Protein, His-tagged
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Cat.#:GSN-2730RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GSN Protein
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Cat.#:Gsn-533RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Gsn Protein, His-tagged
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Cat.#:GSN-6494CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GSN
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Cat.#:GSN-527CTag:His
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle GSN Protein, His-tagged
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Cat.#:GSN-875BTag:
Source (Host):Bovine PlasmaSpecies:Bovine
Product nameNative Bovine GSN Protein
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Cat.#:GSN-874PTag:
Source (Host):Porcine smooth muscleSpecies:Porcine
Product nameNative Porcine GSN Protein
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Cat.#:GSN-876PTag:
Source (Host):Porcine PlasmaSpecies:Porcine
Product nameNative Porcine GSN Protein
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Cat.#:GSN-5722HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GSN 293 Cell Lysate
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Involved Pathway

GSN involved in several pathways and played different roles in them. We selected most pathways GSN participated on our site, such as Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSN were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Fc gamma R-mediated phagocytosis
PIK3R2; WAS; RAC2; GAB2; PPAP2B; WASF2; PLA2G4D; PLD2; CFL1; PPAP2A
Regulation of actin cytoskeleton
ACTN3; PAK2; VIL1; FGFR4; ACTN1; FGF7; CDC42L2; FGF20; RHOAC; PIK3R5
Viral carcinogenesis
LTBR; PIK3R5; CCNE2; HIST2H2BE; GTF2A1L; TRAF5; ACTN3; RBL1; RAC1; HIST1H4E

Protein Function

GSN has several biochemical functions, for example, actin binding, calcium ion binding, myosin II binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GSN itself. We selected most functions GSN had, and list some proteins which have the same functions with GSN. You can find most of the proteins on our site.
Function
Related Protein
Function actin binding
Related Protein GCSAM; ABRA; WIPF1A; VASPA; CAPGA; KLHL20; FSCN2A; HPCA; PHACTR1; CALD1
Function calcium ion binding
Related Protein PCDH2AB10; PCDH1GC5; aLA; VLDLR; PLA2G2D; MYL6; SYT2; MMP19; CASQ1B; NCALDB
Function myosin II binding
Related Protein GCET2; TRIOBP; GSN; GCSAM
Function protein binding
Related Protein FAM46A; TEX14; SUFU; PSMG1; TP53INP1; AIG1; CCNL1; HERC5; MC4R; MIA3
Function protein domain specific binding
Related Protein TNNI3; WNT3A; Ar; HIST1H4J; HIST1H4I; Akap2; HAND2; PRKAR2B; TH; CNTLN

Interacting Protein

GSN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSN here. Most of them are supplied by our site. Hope this information will be useful for your research of GSN.
ESR1; ARRB2; ARRB1; ESR2; act1; act-1; ACTA1; PPM1B; VDAC1; CASP4; TOM1L1; EGFR; q7arf1_yerpe

GSN Related Articles

Van Overbeke, W; Verhelle, A; et al. Chaperone Nanobodies Protect Gelsolin Against MT1-MMP Degradation and Alleviate Amyloid Burden in the Gelsolin Amyloidosis Mouse Model. MOLECULAR THERAPY 22:1768-1778(2014).
Wang, J; Yuan, XP; et al. GSN antibody pretreatment aggravates radiation-induced lung injury in mice. NUCLEAR SCIENCE AND TECHNIQUES 25:-(2014).