Recombinant Full Length Human GSN Protein, C-Flag-tagged

• Cat.No.: GSN-93HFL
• Product Overview: Recombinant Full Length Human GSN Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 82.9 kDa
• AA Sequence: MAPHRPAPALLCALSLALCALSLPV RAATASRGASQAGAPQGRVPEARPN SMVVEHPEFLKAGKEPGLQI WRVEKFDLVPVPTNLYGDFFTGDAY VILKTVQLRNGNLQYDLHYWLGNEC SQDESGAAAIFTVQLDDYLN GRAVQHREVQGFESATFLGYFKSGL KYKKGGVASGFKHVVPNEVVVQRLF QVKGRRVVRATEVPVSWESF NNGDCFILDLGNNIHQWCGSNSNRY ERLKATQVSKGIRDNERSGRARVHV SEEGTEPEAMLQVLGPKPAL PAGTEDTAKEDAANRKLAKLYKVSN GAGTMSVSLVADENPFAQGALKSED CFILDHGKDGKIFVWKGKQA NTEERKAALKTASDFITKMDYPKQT QVSVLPEGGETPLFKQFFKNWRDPD QTDGLGLSYLSSHIANVERV PFDAATLHTSTAMAAQHGMDDDGTG QKQIWRIEGSNKVPVDPATYGQFYG GDSYIILYNYRHGGRQGQII YNWQGAQSTQDEVAASAILTAQLDE ELGGTPVQSRVVQGKEPAHLMSLFG GKPMIIYKGGTSREGGQTAP ASTRLFQVRANSAGATRAVEVLPKA GALNSNDAFVLKTPSAAYLWVGTGA SEAEKTGAQELLRVLRAQPV QVAEGSEPDGFWEALGGKAAYRTSP RLKDKKMDAHPPRLFACSNKIGRFV IEEVPGELMQEDLATDDVML LDTWDQVFVWVGKDSQEEEKTEALT SAKRYIETDPANRDRRTPITVVKQG FEPPSFVGWFLGWDDDYWSV
  DPLDRAMAELAATRTRPLEQKLISE EDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton

Gene Information

• Gene Name: GSN gelsolin [ Homo sapiens (human) ]
• Official Symbol: GSN
• Synonyms: ADF; AGEL
• Gene ID: 2934
• mRNA Refseq: NM_000177.5
• Protein Refseq: NP_000168.1
• MIM: 137350
• UniProt ID: P06396