Recombinant Human GSN Protein, GST-tagged

• Cat.No.: GSN-4401H
• Product Overview: Human GSN full-length ORF ( AAH26033.1, 1 a.a. - 782 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 112.1 kDa
• AA Sequence: MAPHRPAPALLCALSLALCALSLPV RAATASRGASQAGAPQGRVPEARPN SMVVEHPEFLKAGKEPGLQIWRVEK FDLVPVPTNLYGDFFTGDAYVILKT VQLRNGNLQYDLHYWLGNECSQDES GAAAIFTVQLDDYLNGRAVQHREVQ GFESATFLGYFKSGLKYKKGGVASG FKHVVPNEVVVQRLFQVKGRRVVRA TEVPVSWESFNNGDCFILDLGNNIH QWCGSNSNRYERLKATQVSKGIRDN ERSGRARVHVSEEGTEPEAMLQVLG PKPALPAGTEDTAKEDAANRKLAKL YKVSNGAGTMSVSLVADENPFAQGA LKSEDCFILDHGKDGKIFVWKGKQA NTEERKAALKTASDFITKMDYPKQT QVSVLPEGGETPLFKQFFKNWRDPD QTDGLGLSYLSSHIANVERVPFDAA TLHTSTAMAAQHGMDDDGTGQKQIW RIEGSNKVPVDPATYGQFYGGDSYI ILYNYRHGGRQGQIIYNWQGAQSTQ DEVAASAILTAQLDEELGGTPVQSR VVQGKEPAHLMSLFGGKPMIIYKGG TSREGGQTAPASTRLFQVRANSAGA TRAVEVLPKAGALNSNDAFVLKTPS AAYLWVGTGASEAEKTGAQELLRVL RAQPVQVAEGSEPDGFWEALGGKAA YRTSPRLKDKKMDAHPPRLFACSNK IGRFVIEEVPGELMQEDLATDDVML LDTWDQVFVWVGKDSQEEEKTEALT SAKRYIETDPANRDRRTPITVVKQG FEPPSFVGWFLGWDDDYWSVDPLDR AMAELAA
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -8 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: GSN gelsolin [ Homo sapiens ]
• Official Symbol: GSN
• Synonyms: GSN; gelsolin; gelsolin (amyloidosis, Finnish type); amyloidosis; Finnish type; DKFZp313L0718; brevin; actin-depolymerizing factor; ADF; AGEL
• Gene ID: 2934
• mRNA Refseq: NM_000177
• Protein Refseq: NP_000168
• MIM: 137350
• UniProt ID: P06396