hp
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  • Official Full Name
  • Haptoglobin
  • Background
  • As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.
  • Synonyms
  • BP; Haptoglobin alpha chain; Haptoglobin alpha(1S) beta; Haptoglobin alpha(2FS) beta; Haptoglobin beta chain; Haptoglobin, alpha polypeptide; Haptoglobin, beta polypeptide; HP; HP2 ALPHA2; HP2ALPHA2; HPA1S; HPT; MGC111141; Zonulin; MGC111141; hp2-alpha; Haptoglobin; binding peptide; haptoglobin alpha(1S)-beta HP2ALPHA2; haptoglobin alpha(2FS)-beta; haptoglobin, alpha polypeptide; haptoglobin, beta polypeptide
Cat.#:HP-1891HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human HP Protein, MYC/DDK-tagged
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Cat.#:HP-5001HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HP Protein, GST-tagged
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Cat.#:HP-13916HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HP, GST-tagged
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Cat.#:HP-26197THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HP, His-tagged
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Cat.#:HP-5101HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HP, His-tagged
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Cat.#:HP-715HTag:His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human HP Protein, His-tagged
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Cat.#:Hp-7754MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Hp protein, His-tagged
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Cat.#:Hp-7755MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Hp protein, His & T7-tagged
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Cat.#:HP-2895RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HP Protein
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Cat.#:Hp-7757RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Hp protein, His-tagged
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Cat.#:Hp-7758RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Hp protein, His & T7-tagged
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Cat.#:HP-2134RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey HP Protein, His-tagged
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Cat.#:HP-7759RTag:His
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit HP protein, His-tagged
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Cat.#:HP-7760RTag:His/T7
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit HP protein, His & T7-tagged
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Cat.#:HP-7751CTag:His/T7
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle HP protein, His & T7-tagged
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Cat.#:HP-7752CTag:His/T7
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle HP protein, His & T7-tagged
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Cat.#:HP-7756PTag:His
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig HP protein, His-tagged
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Cat.#:Hb-197HTag:
Source (Host):Human Red Blood CellsSpecies:Human
Product nameNative Human Hemoglobin
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Cat.#:HP-127HTag:
Source (Host):Species:Human
Product nameNative Human Hemoglobin protein
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Cat.#:HP-200HTag:
Source (Host):Species:Human
Product nameNative Human Haptoglobin
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Cat.#:HP-26196THTag:
Source (Host):Species:Human
Product nameNative Human HP
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Cat.#:HP-4387HTag:N/A
Source (Host):Pooled human plasmaSpecies:Human
Product nameNative Human Haptoglobin
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Cat.#:HP-8153HTag:N/A
Source (Host):Human SerumSpecies:Human
Product nameNative Human Serum Haptoglobin
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Cat.#:Hp-134MTag:N/A
Source (Host):Mouse serumSpecies:Mouse
Product nameNative Mouse Haptoglobin
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Cat.#:HP-145MTag:
Source (Host):Species:Mouse
Product nameNative Mouse Hemoglobin
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Cat.#:Hp-8155MTag:N/A
Source (Host):Mouse serumSpecies:Mouse
Product nameNative Mouse Serum Haptoglobin
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Cat.#:Hp-194RTag:
Source (Host):Rat SerumSpecies:Rat
Product nameNative Rat Haptoglobin
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Cat.#:HP-190CTag:
Source (Host):Canine (Dog) SerumSpecies:Dog
Product nameNative Dog Haptoglobin
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Cat.#:HP-75CTag:
Source (Host):Canine (dog) SerumSpecies:Canine
Product nameNative Canine Haptoglobin
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Cat.#:HP-133BTag:N/A
Source (Host):Bovine SerumSpecies:Bovine
Product nameNative Bovine Haptoglobin
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Cat.#:HP-146RTag:
Source (Host):Species:Rabbit
Product nameNative Rabbit Hemoglobin
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Cat.#:HP-191ETag:
Source (Host):Horse SerumSpecies:Equine
Product nameNative Equine Haptoglobin
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Cat.#:HP-192FTag:
Source (Host):Feline/Cat SerumSpecies:Cat
Product nameNative Feline Haptoglobin
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Cat.#:HP-193STag:
Source (Host):Porcine SerumSpecies:Pig
Product nameNative Swine Haptoglobin
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Cat.#:HP-199MTag:
Source (Host):Species:Monkey
Product nameNative Monkey Haptoglobin
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Cat.#:HP-5408HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HP 293 Cell Lysate
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Cat.#:HP-14HTag:
Source (Host):Species:Human
Product nameHuman Haptoglobin Reference Standard
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Cat.#:Hp-38MTag:N/A
Source (Host):Species:Mouse
Product nameMouse Haptoglobin Reference Standard
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Cat.#:Hp-80RTag:N/A
Source (Host):Species:Rat
Product namePurified Rat Haptoglobin
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Cat.#:Hp-81RTag:N/A
Source (Host):Species:Rat
Product nameRat Haptoglobin Reference Standard
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Cat.#:HP-6BTag:N/A
Source (Host):Species:Bovine
Product nameBovine Haptoglobin Reference Standard
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Cat.#:HP-68RTag:N/A
Source (Host):Species:Rabbit
Product nameRabbit Haptoglobin Reference Standard
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Cat.#:HP-28HTag:N/A
Source (Host):Species:Equine
Product nameHorse Haptoglobin Reference Standard
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Cat.#:HP-61PTag:N/A
Source (Host):Species:Pig
Product namePig Haptoglobin Reference Standard
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Cat.#:HP-9CTag:N/A
Source (Host):Species:Cat
Product nameCat Haptoglobin Reference Standard
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Involved Pathway

HP involved in several pathways and played different roles in them. We selected most pathways HP participated on our site, such as Binding and Uptake of Ligands by Scavenger Receptors, Scavenging of heme from plasma, Vesicle-mediated transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with HP were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Binding and Uptake of Ligands by Scavenger Receptors
CD163; HSPH1; SAA1; LOC479668; SCGB3A2; Alb; IGLC2; COL1A2; COL1A1; STAB2
Scavenging of heme from plasma
CD163; LOC479668; AMBP; HP; HPX; NFX1
Vesicle-mediated transport
MYO6B; PPP6R1; SEC22A; CX27.5; TGOLN2; TCEAL4; MYO6A; AP3S1; STAB2; SNX9B
amb2 Integrin signaling
HP; LPA; NIPAL1; MST1; CYR61; ELANE; MST1R

Protein Function

HP has several biochemical functions, for example, antioxidant activity, hemoglobin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HP itself. We selected most functions HP had, and list some proteins which have the same functions with HP. You can find most of the proteins on our site.
Function
Related Protein
Function antioxidant activity
Related Protein TP53INP1; TRP53INP1; APOM; APOA4; PRDX5; PRDX6; MT3; APOE; CAT; S100A9
Function hemoglobin binding
Related Protein CUBN; LRP2; HP; HPR; AHSP; HBB
Function protein binding
Related Protein SNRPA; CSRP3; R3HDM2; HSP90AA1.2; FZD3; RBFA; TRIM24; POLR3GL; DHRS1; MMACHC
Function serine-type endopeptidase activity
Related Protein PLG; MMP8; PRSS42; CTRC; FAM108A1; TMPRSS11F; ELA2L; Gzmd; CELA2A; PRSS54

Interacting Protein

HP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HP here. Most of them are supplied by our site. Hope this information will be useful for your research of HP.
APOE; APOA1; MIS12; WASL; TBL1X; GADD45G; TGM2; RPL11; GRB2; SMAD3; MVP; RBBP6

HP Related Articles

Morimoto, M; Saito, C; et al. Impairment of Host Resistance to Helminthes with Age in Murine Small Intestine. PARASITE IMMUNOLOGY 37:171-179(2015).
Do, TD; Park, C; et al. Comparison of pathogenicity of highly pathogenic porcine reproductive and respiratory syndrome virus between wild and domestic pigs. VETERINARY RESEARCH COMMUNICATIONS 39:79-85(2015).