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HP

  • Official Full Name

    Haptoglobin

  • Overview

    As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.
  • Synonyms

    BP; Haptoglobin alpha chain; Haptoglobin alpha(1S) beta; Haptoglobin alpha(2FS) beta; Haptoglobin beta chain; Haptoglobin, alpha polypeptide; Haptoglobin, beta polypeptide; HP; HP2 ALPHA2; HP2ALPHA2; HPA1S; HPT; MGC111141; Zonulin; MGC111141; hp2-alpha; Haptoglobin; binding peptide; haptoglobin alpha(1S)-beta HP2ALPHA2; haptoglobin alpha(2FS)-beta; haptoglobin, alpha polypeptide; haptoglobin, beta polypeptide;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Canine
  • Cat
  • Cattle
  • Dog
  • Equine
  • Goat
  • Hp
  • Human
  • Monkey
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • Rhesus Macaque
  • Acute phase serum
  • Bovine Serum
  • Canine Serum
  • E.coli
  • Feline/Cat Serum
  • HEK293
  • HEK293T
  • Horse Serum
  • Human Milk
  • Human Plasma
  • Human Red Blood Cells
  • Human Serum
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Monkey Plasma
  • Mouse Serum
  • Porcine Serum
  • Rabbit Plasma
  • Rat Serum
  • Solid medium
  • Wheat Germ
  • C
  • His
  • Myc
  • DDK
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|T7
  • B2M
  • MYC
  • Myc|DDK
  • N/A
  • N
  • SUMO
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HP-26197TH Recombinant Human HP, His-tagged E.coli His
Human HP-5001H Recombinant Human HP Protein, GST-tagged Wheat Germ GST
Human HP-13916H Recombinant Human HP, GST-tagged E.coli GST C-term-228a.a.
Human HP-5101H Recombinant Human HP, His-tagged E.coli His
Human HP-715H Recombinant Human HP Protein, His-tagged HEK293 His
Human HP-5408HCL Recombinant Human HP 293 Cell Lysate HEK293 N/A
Human HP-3738HF Recombinant Full Length Human HP Protein, GST-tagged In Vitro Cell Free System GST 281 amino acids
Human HP-079H Recombinant Human HP Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human HP-26196TH Native Human HP N/A
Human HP-14H Active Human Haptoglobin Reference Standard N/A
Human HP-1093H Recombinant Human HP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HP-3049H Recombinant Human HP protein E.coli N/A 19-406aa
Human HP-8153H Native Human Serum Haptoglobin Human Serum N/A
Human HP-1891H Recombinant Human HP Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human HP-2717H Recombinant Human HP Protein (Val19-Asn406), C-His tagged Mammalian cells C-His Val19-Asn406
Human HP-820HFL Recombinant Full Length Human HP Protein, C-Flag-tagged Mammalian cells Flag
Human HP-2718H Recombinant Human HP Protein (Cys145-Asn406), N-His tagged E.coli N-His Cys145-Asn406
Human HP-3048H Recombinant Human HP protein, His-B2M-tagged E.coli His-B2M 19-406aa
Human HP-2719H Recombinant Human HP Protein (Gln160-Glu405), N-His tagged E.coli N-His Gln160-Glu405
Human HP-4387H Native Human Haptoglobin Human Plasma N/A
Human HP-1093H-B Recombinant Human HP Protein Pre-coupled Magnetic Beads HEK293
Human HP-200H Native Human Haptoglobin Human Plasma N/A
Human Hb-197H Native Human Hemoglobin Human Red Blood Cells N/A
Human HP-127H Native Human Hemoglobin protein Human Milk N/A Full length native Hemoglobin protein
Mouse Hp-7754M Recombinant Mouse Hp protein, His-tagged E.coli His Ala118~Cys281 (Accession # Q61646)
Mouse Hp-7755M Recombinant Mouse Hp protein, His & T7-tagged E.coli His/T7 Asp70~Arg332 (Accession # Q61646)
Mouse Hp-134M Native Mouse Haptoglobin Mouse Serum N/A
Mouse Hp-38M Mouse Haptoglobin Reference Standard N/A
Mouse HP-145M Native Mouse Hemoglobin Mouse Serum N/A Full length native Mouse Hemoglobin
Mouse Hp-8155M Native Mouse Serum Haptoglobin Mouse Serum N/A
Mouse Hp-1162M Recombinant Mouse Hp Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat Hp-7758R Recombinant Rat Hp protein, His & T7-tagged E.coli His/T7 Ser70~Arg332 (Accession # P06866)
Rat Hp-7757R Recombinant Rat Hp protein, His-tagged E.coli His Gly125~Gly297 (Accession # P06866)
Rat HP-2895R Recombinant Rat HP Protein Mammalian Cell His
Rat Hp-194R Native Rat Haptoglobin Rat Serum N/A
Rat Hp-81R Rat Haptoglobin Reference Standard N/A
Rat HP-2550R-B Recombinant Rat HP Protein Pre-coupled Magnetic Beads HEK293
Rat HP-957R Recombinant Rat Haptoglobin Protein (Met1-Asn347), His-tagged HEK293 His Met1-Asn347
Rat Hp-80R Purified Rat Haptoglobin N/A
Rat HP-2550R Recombinant Rat HP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HP-5310R Recombinant Rat HP protein, His-tagged E.coli His 19-346aa
Monkey HP-199M Native Monkey Haptoglobin Monkey Plasma N/A
Rabbit HP-7759R Recombinant Rabbit HP protein, His-tagged E.coli His Phe21~Asp98 (Accession # P19007)
Rabbit HP-7760R Recombinant Rabbit HP protein, His & T7-tagged E.coli His/T7 Val177~Lys342 (Accession # P19007)
Rabbit HP-68R Rabbit Haptoglobin Reference Standard N/A
Rabbit HP-7761R Native Rabbit Haptoglobin Protein Acute phase serum
Rabbit HP-146R Native Rabbit Hemoglobin Rabbit Plasma N/A Full length native Rabbit Hemoglobin
Dog HP-190C Native Dog Haptoglobin Canine Serum N/A
Bovine HP-133B Native Bovine Haptoglobin Bovine Serum N/A
Bovine HP-6B Bovine Haptoglobin Reference Standard N/A
Canine HP-75C Native Canine Haptoglobin Canine Serum N/A
Cat HP-192F Native Feline Haptoglobin Feline/Cat Serum N/A
Cat HP-9C Cat Haptoglobin Reference Standard N/A
Cattle HP-7752C Recombinant Cattle HP protein, His & T7-tagged E.coli His/T7 Val19~Gln155 (Accession # Q2TBU0)
Cattle HP-7751C Recombinant Cattle HP protein, His & T7-tagged E.coli His/T7 Gly159~Leu329 (Accession # Q2TBU0)
Equine HP-28H Horse Haptoglobin Reference Standard N/A
Equine HP-191E Native Equine Haptoglobin Horse Serum N/A
Goat HP-2770G Recombinant Goat HP Protein, His&SUMO-tagged E.coli N-His&SUMO Val19-Asn401
Hp Hp-25 Native Helicobacter pylori Antigen Solid medium
Rhesus Macaque HP-2134R Recombinant Rhesus monkey HP Protein, His-tagged Mammalian Cell His
Rhesus Macaque HP-1955R Recombinant Rhesus Macaque HP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque HP-1955R-B Recombinant Rhesus Macaque HP Protein Pre-coupled Magnetic Beads HEK293
Pig HP-7756P Recombinant Pig HP protein, His-tagged E.coli His His123~Asp307 (Accession # Q8SPS7)
Pig HP-193S Native Swine Haptoglobin Porcine Serum N/A
Pig HP-61P Pig Haptoglobin Reference Standard N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HP Related Articles
  • HP Related Research Area

HP involved in several pathways and played different roles in them. We selected most pathways HP participated on our site, such as Binding and Uptake of Ligands by Scavenger Receptors, Scavenging of heme from plasma, Vesicle-mediated transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with HP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Binding and Uptake of Ligands by Scavenger ReceptorsSCGB3A2;AMBP;HYOU1;SPARC;IGKV1-5;Alb;IGLC2;NFX1;SAA1
Scavenging of heme from plasmaHP;LOC479668;HPX;NFX1;AMBP;CD163
Vesicle-mediated transportSEC22A;COPZ1;BLOC1S4;TRAPPC3;SNX9B;NAPG;BLOC1S6;CLVS1;COPB1
amb2 Integrin signalingCYR61;MST1R;HP;ELANE;LPA;MST1;NIPAL1

HP has several biochemical functions, for example, antioxidant activity, hemoglobin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HP itself. We selected most functions HP had, and list some proteins which have the same functions with HP. You can find most of the proteins on our site.

Function Related Protein
antioxidant activityMT3;SEPW1;PRDX6;FAM213AA;PRDX5;PRDX2;TP53INP1;S100A9;CAT
hemoglobin bindingHPR;HP;HBB;CUBN;AHSP;LRP2
protein bindingFNTA;NUF2;IFT46;RSPH9;TRIM21;BCL11A;PAWR;UBE2IB;PRDX3
serine-type endopeptidase activityPREP;HTRA3;GZMH;F7I;ELA2;F12;PCSK2;KLK6;MCPT8

HP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HP here. Most of them are supplied by our site. Hope this information will be useful for your research of HP.

APOE; APOA1; MIS12; WASL; TBL1X; GADD45G; TGM2; RPL11; GRB2; SMAD3; MVP; RBBP6

Morimoto, M; Saito, C; et al. Impairment of Host Resistance to Helminthes with Age in Murine Small Intestine. PARASITE IMMUNOLOGY 37:171-179(2015).
Do, TD; Park, C; et al. Comparison of pathogenicity of highly pathogenic porcine reproductive and respiratory syndrome virus between wild and domestic pigs. VETERINARY RESEARCH COMMUNICATIONS 39:79-85(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can Haptoglobin levels be influenced by genetic factors? 05/20/2020

Yes, genetic variations can affect Haptoglobin levels, and understanding these variations can be crucial for personalized medicine approaches.

How does Haptoglobin contribute to the body's defense against oxidative stress? 01/20/2020

Haptoglobin acts as an antioxidant by binding to free hemoglobin, preventing the formation of reactive oxygen species that contribute to oxidative stress.

Are there any specific diseases where monitoring Haptoglobin is particularly crucial? 02/28/2019

Conditions such as hemolytic anemias, infections, and chronic inflammatory diseases often require monitoring Haptoglobin levels for diagnostic and prognostic purposes.

How is the Haptoglobin test performed in a clinical setting? 10/19/2017

The Haptoglobin test is usually conducted through a blood sample, and the serum or plasma is analyzed for Haptoglobin levels.

Can Haptoglobin be a diagnostic marker for conditions other than hemolysis and inflammation? 01/09/2016

Yes, altered levels of Haptoglobin are associated with various conditions, including cardiovascular diseases, infections, and certain cancers.

Customer Reviews (3)

Write a review
Reviews
07/02/2022

    Its superior purity and stability ensure reliable and reproducible results, providing me with confidence in the integrity of my experiments.

    01/18/2020

      Its impeccable purity and stability ensure accurate and reproducible results, giving me confidence in the reliability of my research outcomes

      07/07/2019

        Whether I am investigating protein-protein interactions, studying enzymatic activity, or conducting protein structure analyses, the HP protein consistently delivers exceptional performance and accurate results.

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