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HPSE

  • Official Full Name

    heparanase

  • Overview

    Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
  • Synonyms

    HPSE; heparanase; HPA; HPA1; HPR1; HSE1; HPSE1; heparanase-1; endo-glucoronidase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • CHO
  • E.coli
  • HEK293
  • Mammalian Cell
  • Myeloma cells
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HPSE-431H Active Recombinant Human HPSE protein, His-tagged CHO His
Human HPSE-156H Active Recombinant Human HPSE, His-tagged CHO His
Human HPSE-213H Recombinant Human Heparanase CHO N/A
Human HPSE-5068H Recombinant Human HPSE, His-tagged E.coli His
Human HPSE-5019H Recombinant Human HPSE Protein, GST-tagged Wheat Germ GST
Human HPSE-467H Recombinant Human heparanase, His-tagged E.coli His
Human HPSE-5393HCL Recombinant Human HPSE 293 Cell Lysate HEK293 N/A
Human HPSE-3443H Recombinant Human HPSE Protein (Gln34-Arg115), N-His tagged E.coli N-His Gln34-Arg115
Human HPSE-2252H Recombinant Human HPSE Protein, His-tagged E.coli N-His Leu151-Ile543
Human HPSE-2251H Recombinant Human HPSE Protein, His-tagged E.coli N-His Pro400-Ile543
Mouse HPSE-7838M Active Recombinant Mouse HPSE Protein, His-tagged Myeloma cells His 28-535
Mouse Hpse-704M Recombinant Mouse Hpse protein, His-tagged E.coli His Glu280~Leu412 (Accession # Q6YGZ1)
Mouse Hpse-706M Recombinant Mouse Hpse protein, His-tagged E.coli His Ala353~Arg464 (Accession # Q6YGZ1)
Mouse Hpse-705M Recombinant Mouse Hpse protein, His-tagged E.coli His Asp419~Ile535 (Accession # Q6YGZ1)
Mouse Hpse-703M Recombinant Mouse Hpse protein, His-tagged E.coli His Thr27~Glu101 (Accession # Q6YGZ1)
Rat HPSE-2907R Recombinant Rat HPSE Protein Mammalian Cell His
Rat Hpse-707R Recombinant Rat Hpse protein, His & T7-tagged E.coli His/T7 Arg40~Pro188 (Accession # Q71RP1)
Rat HPSE-2562R Recombinant Rat HPSE Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HPSE-2562R-B Recombinant Rat HPSE Protein Pre-coupled Magnetic Beads HEK293
Rat Hpse-3051R Recombinant Rat Hpse protein, His&Myc-tagged E.coli His&Myc 29-102aa
Zebrafish HPSE-4085Z Recombinant Zebrafish HPSE Mammalian Cell His
Chicken HPSE-5742C Recombinant Chicken HPSE Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HPSE Related Articles
  • HPSE Related Research Area

HPSE involved in several pathways and played different roles in them. We selected most pathways HPSE participated on our site, such as Glycosaminoglycan degradation, Glycosaminoglycan metabolism, HS-GAG degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HPSE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycosaminoglycan degradationHGSNAT;GNS;SGSH;GUSB;HYAL6;HYAL1;HEXB;GALNS;GNSB
Glycosaminoglycan metabolismB3GNT3;SLC26A2;SLC35D2;HPSE;B3GNT2A;OMD;CHST14;SLC35B2;HAS1
HS-GAG degradationGLB1L;Gpc2;HPSE;GPC1B;GPC5A;GPC1A
Heparan sulfate/heparin (HS-GAG) metabolismGPC1A;CSPG5B;GPC1B;Gpc2;GPC5A;HS3ST4;SLC35D2;MAPK1IP1L;B3GAT2
Metabolic pathwaysCKMT1B;LASS5;NOS2A;ENPP7;RRM2B;PIGH;ATP6V0C;AKR1B7;ACO1
MetabolismPITPNB;NDOR1;UGT1B3;DHCR7;OMD;CKM;AK7A;NUDT4;SLC35B2
Metabolism of carbohydratesSLC35B3;SLC25A1;FMODA;Gpc2;HPSE;SLC35D2;B3GNT2;HS3ST6;GCKR
Proteoglycans in cancerITGA5;CAMK2D;VAV2;ESR1;TWIST1;CAV2;FZD8;ITGA2;FZD2

HPSE has several biochemical functions, for example, beta-glucuronidase activity, heparanase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HPSE itself. We selected most functions HPSE had, and list some proteins which have the same functions with HPSE. You can find most of the proteins on our site.

Function Related Protein
beta-glucuronidase activityGUSB;HPSE
heparanase activity
protein bindingEIF3C;FABP5;EGR2;GNAT1;TCF4;FNTA;ZNF544;HIST1H2AK;AHSP
protein dimerization activityHER8.2;OLIG4;SLC4A11;FERD3L;NPAS4A;MGAA;HES3;TFAP2B;SOHLH1
syndecan bindingSDCBP;CHRD;TNC;HPSE;SEMA5A

HPSE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HPSE here. Most of them are supplied by our site. Hope this information will be useful for your research of HPSE.

ssrna_ug

Zhang, J; Yang, JM; et al. Multiple antigenic polypeptide composed of heparanase B-cell epitopes shrinks human hepatocellular carcinoma in mice. ONCOLOGY REPORTS 33:1248-1256(2015).
Zhang, J; Yang, JM; et al. Synthesized Multiple Antigenic Polypeptide Vaccine Based on B-Cell Epitopes of Human Heparanase Could Elicit a Potent Antimetastatic Effect on Human Hepatocellular Carcinoma In Vivo. PLOS ONE 8:-(2013).
  • Q&As
  • Reviews

Q&As (6)

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What is the role of HPSE protein in tumor immune evasion? 11/04/2022

By regulating the tumor microenvironment and the function of immune cells, HPSE protein participates in the process of tumor immune evasion.

Does HPSE protein have potential applications in tumor immunotherapy? 05/26/2022

Yes, the mechanism by which HPSE proteins act in relation to tumor immunotherapy has potential applications in this regard.

How about the fuction of HPSE protein in liver fibrosis? 09/30/2021

The protein plays an important role in liver fibrosis and participates in the regulation of liver tissue fibrosis through mechanisms such as collagen degradation.

How does HPSE protein participate in tumor invasion and metastasis? 08/25/2020

HPSE protein is involved in regulating tumor invasion and metastasis by degrading the basement membrane and promoting cytotoxicity.

What is the role of HPSE protein in collagen degradation, tissue repair and regeneration? 01/24/2020

The protein plays an important role in collagen degradation, tissue repair and regeneration, participates in epithelial-mesenchymal transformation processes, and affects biological processes such as cell migration and remodeling.

What is the role of HPSE protein in inflammatory response? 05/26/2019

HPSE proteins play an important role in the inflammatory response by participating in mechanisms such as extracellular matrix degradation and mediating cytokine production and release.

Customer Reviews (2)

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Reviews
12/08/2019

    The stability of HPSE was still very good under different temperature conditions, indicating that it has excellent thermal stability.

    05/19/2019

      Beacuse high efficiency and wide storage conditions of proteins make the experimental process more convenient and greatly improve the efficiency of scientific research.

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