hpse
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  • Official Full Name
  • heparanase
  • Background
  • Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
  • Synonyms
  • HPSE; heparanase; HPA; HPA1; HPR1; HSE1; HPSE1; heparanase-1; endo-glucoronidase;
Cat.#:HPSE-5019HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HPSE Protein, GST-tagged
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Cat.#:HPSE-156HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human HPSE, His-tagged
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Cat.#:HPSE-213HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Heparanase
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Cat.#:HPSE-431HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human HPSE protein, His-tagged
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Cat.#:HPSE-467HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human heparanase, His-tagged
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Cat.#:HPSE-5068HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HPSE, His-tagged
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Cat.#:Hpse-703MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Hpse protein, His-tagged
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Cat.#:Hpse-704MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Hpse protein, His-tagged
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Cat.#:Hpse-705MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Hpse protein, His-tagged
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Cat.#:Hpse-706MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Hpse protein, His-tagged
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Cat.#:HPSE-7838MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HPSE Protein
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Cat.#:HPSE-2907RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HPSE Protein
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Cat.#:Hpse-707RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Hpse protein, His & T7-tagged
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Cat.#:HPSE-5742CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken HPSE
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Cat.#:HPSE-4085ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish HPSE
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Cat.#:HPSE-5393HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HPSE 293 Cell Lysate
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Involved Pathway

HPSE involved in several pathways and played different roles in them. We selected most pathways HPSE participated on our site, such as Glycosaminoglycan degradation, Glycosaminoglycan metabolism, HS-GAG degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HPSE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycosaminoglycan degradation
HYAL6; HEXA; GNSB; GNSA; HYAL3; HYAL2; ARSB; IDUA; HGSNAT; SPAM1
Glycosaminoglycan metabolism
B3GNT2; STAB2; B3GNT1; HS3ST6; ST3GAL3A; GLB1L; LYVE1; HPSE; FMODA; B3GNT2A
HS-GAG degradation
Gpc2; HPSE; GPC5A; GLB1L; GPC1B; GPC1A
Heparan sulfate/heparin (HS-GAG) metabolism
MAPK1IP1L; B4GALT7; GPC1B; HS3ST6; HPSE; GLB1L; HS3ST4; GPC1A; GPC5A; SLC35D2
Metabolic pathways
CBR1; PAH; URAD; ACOX1; MCAT; KDSR; SAT1A.2; SPTLC1; PIP5KL1; NFS1
Metabolism
OXSR1; SUMF2; NDOR1; CYGB; C20orf7; DGUOK; TIAM2; NUDT5; SULT2ST1; NUDT11
Metabolism of carbohydrates
AGL; HAS1; SLC25A1A; CHST9; SLC5A9; B3GNT2; SLC25A13; NHLRC1; OXSR1; EPM2A
Proteoglycans in cancer
TGFB2; TP53; CAV3; IGF1R; IGF2; COL21A1; PAK1; HRAS; MAP2K1; PRKCG

Protein Function

HPSE has several biochemical functions, for example, beta-glucuronidase activity, heparanase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HPSE itself. We selected most functions HPSE had, and list some proteins which have the same functions with HPSE. You can find most of the proteins on our site.
Function
Related Protein
Function beta-glucuronidase activity
Related Protein HPSE; GUSB
Function heparanase activity
Related Protein HPSE
Function protein binding
Related Protein AKAP17A; PDXP; PDE6H; DDX23; TRIM25; PARP2; KIF20B; GTF2H4; GLRA1; CHMP4B
Function protein dimerization activity
Related Protein SIM1A; CLOCKB; ASCL2; HER2; FIGLA; ASCL1A; HPS4; HER4.2; MYCB; FERD3L
Function syndecan binding
Related Protein TNC; CHRD; HPSE; SDCBP; SEMA5A

Interacting Protein

HPSE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HPSE here. Most of them are supplied by our site. Hope this information will be useful for your research of HPSE.
ssrna_ug

HPSE Related Articles

Zhang, J; Yang, JM; et al. Multiple antigenic polypeptide composed of heparanase B-cell epitopes shrinks human hepatocellular carcinoma in mice. ONCOLOGY REPORTS 33:1248-1256(2015).
Zhang, J; Yang, JM; et al. Synthesized Multiple Antigenic Polypeptide Vaccine Based on B-Cell Epitopes of Human Heparanase Could Elicit a Potent Antimetastatic Effect on Human Hepatocellular Carcinoma In Vivo. PLOS ONE 8:-(2013).