HPSE
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Official Full Name
heparanase
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Overview
Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] -
Synonyms
HPSE; heparanase; HPA; HPA1; HPR1; HSE1; HPSE1; heparanase-1; endo-glucoronidase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- CHO
- E.coli
- HEK293
- Mammalian Cell
- Myeloma cells
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- His|T7
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | HPSE-431H | Active Recombinant Human HPSE protein, His-tagged | CHO | His | ||
Human | HPSE-156H | Active Recombinant Human HPSE, His-tagged | CHO | His | ||
Human | HPSE-213H | Recombinant Human Heparanase | CHO | N/A | ||
Human | HPSE-5068H | Recombinant Human HPSE, His-tagged | E.coli | His | ||
Human | HPSE-5019H | Recombinant Human HPSE Protein, GST-tagged | Wheat Germ | GST | ||
Human | HPSE-467H | Recombinant Human heparanase, His-tagged | E.coli | His | ||
Human | HPSE-5393HCL | Recombinant Human HPSE 293 Cell Lysate | HEK293 | N/A | ||
Human | HPSE-3443H | Recombinant Human HPSE Protein (Gln34-Arg115), N-His tagged | E.coli | N-His | Gln34-Arg115 | |
Human | HPSE-2252H | Recombinant Human HPSE Protein, His-tagged | E.coli | N-His | Leu151-Ile543 | |
Human | HPSE-2251H | Recombinant Human HPSE Protein, His-tagged | E.coli | N-His | Pro400-Ile543 | |
Mouse | HPSE-7838M | Active Recombinant Mouse HPSE Protein, His-tagged | Myeloma cells | His | 28-535 | |
Mouse | Hpse-704M | Recombinant Mouse Hpse protein, His-tagged | E.coli | His | Glu280~Leu412 (Accession # Q6YGZ1) | |
Mouse | Hpse-706M | Recombinant Mouse Hpse protein, His-tagged | E.coli | His | Ala353~Arg464 (Accession # Q6YGZ1) | |
Mouse | Hpse-705M | Recombinant Mouse Hpse protein, His-tagged | E.coli | His | Asp419~Ile535 (Accession # Q6YGZ1) | |
Mouse | Hpse-703M | Recombinant Mouse Hpse protein, His-tagged | E.coli | His | Thr27~Glu101 (Accession # Q6YGZ1) | |
Rat | HPSE-2907R | Recombinant Rat HPSE Protein | Mammalian Cell | His | ||
Rat | Hpse-707R | Recombinant Rat Hpse protein, His & T7-tagged | E.coli | His/T7 | Arg40~Pro188 (Accession # Q71RP1) | |
Rat | HPSE-2562R | Recombinant Rat HPSE Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | HPSE-2562R-B | Recombinant Rat HPSE Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | Hpse-3051R | Recombinant Rat Hpse protein, His&Myc-tagged | E.coli | His&Myc | 29-102aa | |
Zebrafish | HPSE-4085Z | Recombinant Zebrafish HPSE | Mammalian Cell | His | ||
Chicken | HPSE-5742C | Recombinant Chicken HPSE | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- HPSE Related Articles
- HPSE Related Research Area
HPSE involved in several pathways and played different roles in them. We selected most pathways HPSE participated on our site, such as Glycosaminoglycan degradation, Glycosaminoglycan metabolism, HS-GAG degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HPSE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Glycosaminoglycan degradation | HGSNAT;GNS;SGSH;GUSB;HYAL6;HYAL1;HEXB;GALNS;GNSB |
Glycosaminoglycan metabolism | B3GNT3;SLC26A2;SLC35D2;HPSE;B3GNT2A;OMD;CHST14;SLC35B2;HAS1 |
HS-GAG degradation | GLB1L;Gpc2;HPSE;GPC1B;GPC5A;GPC1A |
Heparan sulfate/heparin (HS-GAG) metabolism | GPC1A;CSPG5B;GPC1B;Gpc2;GPC5A;HS3ST4;SLC35D2;MAPK1IP1L;B3GAT2 |
Metabolic pathways | CKMT1B;LASS5;NOS2A;ENPP7;RRM2B;PIGH;ATP6V0C;AKR1B7;ACO1 |
Metabolism | PITPNB;NDOR1;UGT1B3;DHCR7;OMD;CKM;AK7A;NUDT4;SLC35B2 |
Metabolism of carbohydrates | SLC35B3;SLC25A1;FMODA;Gpc2;HPSE;SLC35D2;B3GNT2;HS3ST6;GCKR |
Proteoglycans in cancer | ITGA5;CAMK2D;VAV2;ESR1;TWIST1;CAV2;FZD8;ITGA2;FZD2 |
HPSE has several biochemical functions, for example, beta-glucuronidase activity, heparanase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HPSE itself. We selected most functions HPSE had, and list some proteins which have the same functions with HPSE. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
beta-glucuronidase activity | GUSB;HPSE |
heparanase activity | |
protein binding | EIF3C;FABP5;EGR2;GNAT1;TCF4;FNTA;ZNF544;HIST1H2AK;AHSP |
protein dimerization activity | HER8.2;OLIG4;SLC4A11;FERD3L;NPAS4A;MGAA;HES3;TFAP2B;SOHLH1 |
syndecan binding | SDCBP;CHRD;TNC;HPSE;SEMA5A |
HPSE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HPSE here. Most of them are supplied by our site. Hope this information will be useful for your research of HPSE.
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- Q&As
- Reviews
Q&As (6)
Ask a questionBy regulating the tumor microenvironment and the function of immune cells, HPSE protein participates in the process of tumor immune evasion.
Yes, the mechanism by which HPSE proteins act in relation to tumor immunotherapy has potential applications in this regard.
The protein plays an important role in liver fibrosis and participates in the regulation of liver tissue fibrosis through mechanisms such as collagen degradation.
HPSE protein is involved in regulating tumor invasion and metastasis by degrading the basement membrane and promoting cytotoxicity.
The protein plays an important role in collagen degradation, tissue repair and regeneration, participates in epithelial-mesenchymal transformation processes, and affects biological processes such as cell migration and remodeling.
HPSE proteins play an important role in the inflammatory response by participating in mechanisms such as extracellular matrix degradation and mediating cytokine production and release.
Customer Reviews (2)
Write a reviewThe stability of HPSE was still very good under different temperature conditions, indicating that it has excellent thermal stability.
Beacuse high efficiency and wide storage conditions of proteins make the experimental process more convenient and greatly improve the efficiency of scientific research.
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