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Recombinant Mouse Hpse protein, His-tagged

Cat.No. : Hpse-704M
Product Overview : Recombinant Mouse Hpse aa. (Glu280~Leu412 (Accession # Q6YGZ1)) fused with N-terminal His tag was produced in E. coli cells.
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  • Gene Information
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Description : This gene encodes an endoglucuronidase enzyme that plays an important role in tumor invasion and metastasis. The encoded preproprotein undergoes proteolytic processing to generate an active heterodimeric enzyme that cleaves the heparan sulfate proteoglycans associated with the cell surface and extracellular matrix. Mice lacking the encoded protein do not show any prominent pathological alterations under normal conditions but fail to develop albuminuria and renal damage in response to drug-induced diabetes.
Source : E. coli
Species : Mouse
Tag : His
Form : Freeze-dried powder
Molecular Mass : 16 kDa as determined by SDS-PAGE reducing conditions.
Protein length : Glu280~Leu412 (Accession # Q6YGZ1)
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 6.6.
Applications : SDS-PAGE; WB; ELISA; IP
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in PBS, pH7.4.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : Hpse heparanase [ Mus musculus (house mouse) ]
Official Symbol : Hpse
Synonyms : Hpse; heparanase; Hpa; HSE1; Hpr1; endo-glucoronidase; endoglycosidase heparanase
Gene ID : 15442
mRNA Refseq : NM_152803.5
Protein Refseq : NP_690016.1
UniProt ID : Q6YGZ1

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the role of HPSE protein in tumor immune evasion? 11/04/2022

By regulating the tumor microenvironment and the function of immune cells, HPSE protein participates in the process of tumor immune evasion.

Does HPSE protein have potential applications in tumor immunotherapy? 05/26/2022

Yes, the mechanism by which HPSE proteins act in relation to tumor immunotherapy has potential applications in this regard.

How about the fuction of HPSE protein in liver fibrosis? 09/30/2021

The protein plays an important role in liver fibrosis and participates in the regulation of liver tissue fibrosis through mechanisms such as collagen degradation.

How does HPSE protein participate in tumor invasion and metastasis? 08/25/2020

HPSE protein is involved in regulating tumor invasion and metastasis by degrading the basement membrane and promoting cytotoxicity.

What is the role of HPSE protein in collagen degradation, tissue repair and regeneration? 01/24/2020

The protein plays an important role in collagen degradation, tissue repair and regeneration, participates in epithelial-mesenchymal transformation processes, and affects biological processes such as cell migration and remodeling.

What is the role of HPSE protein in inflammatory response? 05/26/2019

HPSE proteins play an important role in the inflammatory response by participating in mechanisms such as extracellular matrix degradation and mediating cytokine production and release.

Customer Reviews (2)

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Reviews
12/08/2019

    The stability of HPSE was still very good under different temperature conditions, indicating that it has excellent thermal stability.

    05/19/2019

      Beacuse high efficiency and wide storage conditions of proteins make the experimental process more convenient and greatly improve the efficiency of scientific research.

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