HSD17B12 Protein, hydroxysteroid (17-beta) dehydrogenase 12

HSD17B12

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HSD17B12

Official Full Name hydroxysteroid (17-beta) dehydrogenase 12
Background This gene encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation.
Synonyms HSD17B12; hydroxysteroid (17-beta) dehydrogenase 12; estradiol 17-beta-dehydrogenase 12; 3 ketoacyl CoA reductase; KAR; SDR12C1; short chain dehydrogenase/reductase family 12C; member 1; 17 beta HSD 12; 17 beta hydroxysteroid dehydrogenase 12; 17-@beta-HSD XII; 17-@beta-hydroxysteroid dehydrogenase XII; 17-beta-HSD 12; 17-beta-hydroxysteroid dehydrogenase 12; 17beta HSD type 12; 3-ketoacyl-CoA reductase; DHB12_HUMAN; Estradiol 17 beta dehydrogenase 12; KIK-I; Kik1; Short chain dehydrogenase/reductase family 12Cmember 1; Steroid dehydrogenase homolog; 17beta-HSD type 12; OTTHUMP00000232808; short chain dehydrogenase/reductase family 12C, member 1
    • Species :
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HSD17B12-1409H Recombinant Human HSD17B12 protein, His-tagged E.coli His
    Human HSD17B12-46H Recombinant Human HSD17B12, GST-tagged Wheat Germ GST
    Human HSD17B12-47H Recombinant Human HSD17B12, GST-tagged Wheat Germ GST
    Human HSD17B12-818HCL Recombinant Human HSD17B12 cell lysate N/A
    Mouse Hsd17b12-1410M Recombinant Mouse Hsd17b12 protein, His & GST-tagged E.coli His/GST
    Mouse HSD17B12-7874M Recombinant Mouse HSD17B12 Protein Mammalian Cell His
    Rat Hsd17b12-1411R Recombinant Rat Hsd17b12 protein, His & GST-tagged E.coli His/GST
    Rat HSD17B12-2924R Recombinant Rat HSD17B12 Protein Mammalian Cell His
    Cynomolgus Monkey HSD17B12-599C Recombinant Cynomolgus HSD17B12 Protein, His-tagged Mammalian Cell His

    HSD17B12 involved in several pathways and played different roles in them. We selected most pathways HSD17B12 participated on our site, such as Fatty acid elongation, Steroid hormone biosynthesis, Biosynthesis of unsaturated fatty acids, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSD17B12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Fatty acid elongation ELOVL7A; ELOVL6; TECR; HSD17B12B; ACAA2; ELOVL1; ACOT2; TECRB; HADHA; ACOT7
    Steroid hormone biosynthesis UGT1A9; UGT1A7C; CYP2D26; UGT2B7; UGT2A3; HSD11B2; HSD3B2; HSD11B1; AKR1C2; CYP3A65
    Biosynthesis of unsaturated fatty acids PTPLAD2; ACOX1; PTPLA; HADHAB; Scd1; BAAT; SCD5; FADS1; HADHAA; ELOVL5
    Metabolic pathways EXT1A; MAN2A1; COX7B; TPO; SPR; TPK1; ASS1; GOT1; UGT1A3; MTHFD1B
    Fatty acid metabolism ACOX3; ACAA1; OXSM; ACADVL; CPT1C; ACAT1; ACSL3; PECR; CPT1A; PTPLAD2

    HSD17B12 has several biochemical functions, for example, collagen binding, estradiol 17-beta-dehydrogenase activity, fibronectin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSD17B12 itself. We selected most functions HSD17B12 had, and list some proteins which have the same functions with HSD17B12. You can find most of the proteins on our site.

    Function Related Protein
    collagen binding CTSL1; CTSS; CD44; ITGA1; ABI3BP; VWF; CTSK; Pdgfa&Pdgfb; C1QTNF1; ACHE
    estradiol 17-beta-dehydrogenase activity AKR1C6; HSD17B12A; HSD17B7; RDH8A; HSD17B12B; HSD17B10; RDH8B; AKR1B15; HSD17B1; HSD17B8
    fibronectin binding FSTL3; ITGA3; ITGB1A; CTGF; VEGFA; CTSK; LACRT; IGFBP3; ITGB3; MYOC
    heparin binding FGF4; VEGFB; FGF7; CCL8; LAMC2; GREM2; SERPINA10; RPL29; VEGFAA; FGFBP3
    protein binding GJD3; NIPA2; DKK1; ATP6V0A1; FAM54A; SET; DAAM1; OSGIN1; PIPOX; AMBRA1

    HSD17B12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSD17B12 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSD17B12.

    UBQLN1; UBQLN1; vpu; CLN3; 1C; BECN1; P; HDAC11; SLC38A1

    Li, Z; Van, LT; et al. Expression of enzymes involved in synthesis and metabolism of estradiol in human breast as studied by immunocytochemistry and in situ hybridization. HISTOLOGY AND HISTOPATHOLOGY 24:273-282(2009).
    Brown, KA; Sayasith, K; et al. Molecular cloning of equine 17 beta-hydroxysteroid dehydrogenase type 1 and its downregulation during follicular luteinization in vivo. JOURNAL OF MOLECULAR ENDOCRINOLOGY 38:67-78(2007).

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