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HSD17B12

  • Official Full Name

    hydroxysteroid (17-beta) dehydrogenase 12

  • Overview

    This gene encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation.
  • Synonyms

    HSD17B12; hydroxysteroid (17-beta) dehydrogenase 12; estradiol 17-beta-dehydrogenase 12; 3 ketoacyl CoA reductase; KAR; SDR12C1; short chain dehydrogenase/reductase family 12C; member 1; 17 beta HSD 12; 17 beta hydroxysteroid dehydrogenase 12; 17-@beta-HSD XII; 17-@beta-hydroxysteroid dehydrogenase XII; 17-beta-HSD 12; 17-beta-hydroxysteroid dehydrogenase 12; 17beta HSD type 12; 3-ketoacyl-CoA reductase; DHB12_HUMAN; Estradiol 17 beta dehydrogenase 12; KIK-I; Kik1; Short chain dehydrogenase/reductase family 12Cmember 1; Steroid dehydrogenase homolog; 17beta-HSD type 12; OTTHUMP00000232808; short chain dehydrogenase/reductase family 12C, member 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Anas platyrhynchos (Mallard) (Anas boschas)
  • Bos taurus (Bovine)
  • Cynomolgus Monkey
  • Homo sapiens (Human)
  • Human
  • Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HSD17B12-46H Recombinant Human HSD17B12, GST-tagged Wheat Germ GST
Human HSD17B12-1409H Recombinant Human HSD17B12 protein, His-tagged E.coli His Met1~Asn312
Human HSD17B12-47H Recombinant Human HSD17B12, GST-tagged Wheat Germ GST
Human HSD17B12-818HCL Recombinant Human HSD17B12 cell lysate N/A
Human HSD17B12-3534H Recombinant Human HSD17B12 Protein (Met1-Asn312), His tagged E.coli His Met1-Asn312
Human HSD17B12-2821H Recombinant Human HSD17B12 protein, His-tagged E.coli His 203 - 271 aa
Mouse HSD17B12-7874M Recombinant Mouse HSD17B12 Protein Mammalian Cell His
Mouse Hsd17b12-1410M Recombinant Mouse Hsd17b12 protein, His & GST-tagged E.coli His/GST Met1~Asn312 (Accession # O70503)
Mouse Hsd17b12-3441M Recombinant Mouse Hsd17b12 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse HSD17B12-4333M-B Recombinant Mouse HSD17B12 Protein Pre-coupled Magnetic Beads HEK293
Mouse HSD17B12-4333M Recombinant Mouse HSD17B12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Hsd17b12-1411R Recombinant Rat Hsd17b12 protein, His & GST-tagged E.coli His/GST Leu11~Phe291 (Accession # Q6P7R8)
Rat HSD17B12-2924R Recombinant Rat HSD17B12 Protein Mammalian Cell His
Rat HSD17B12-2579R Recombinant Rat HSD17B12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HSD17B12-2579R-B Recombinant Rat HSD17B12 Protein Pre-coupled Magnetic Beads HEK293
Anas platyrhynchos (Mallard) (Anas boschas) RFL19200AF Recombinant Full Length Anas Platyrhynchos Estradiol 17-Beta-Dehydrogenase 12(Hsd17B12) Protein, His-Tagged E.coli expression system His Full Length (1-312)
Bos taurus (Bovine) RFL20946BF Recombinant Full Length Bovine Estradiol 17-Beta-Dehydrogenase 12(Hsd17B12) Protein, His-Tagged E.coli expression system His Full Length (1-312)
Cynomolgus Monkey HSD17B12-599C Recombinant Cynomolgus HSD17B12 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey HSD17B12-345C Recombinant Cynomolgus Monkey HSD17B12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey HSD17B12-345C-B Recombinant Cynomolgus Monkey HSD17B12 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL24277HF Recombinant Full Length Human Estradiol 17-Beta-Dehydrogenase 12(Hsd17B12) Protein, His-Tagged E.coli expression system His Full Length (1-312)
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) RFL20747MF Recombinant Full Length Macaca Fascicularis Estradiol 17-Beta-Dehydrogenase 12(Hsd17B12) Protein, His-Tagged E.coli expression system His Full Length (1-312)
Mus musculus (Mouse) RFL21344MF Recombinant Full Length Mouse Estradiol 17-Beta-Dehydrogenase 12(Hsd17B12) Protein, His-Tagged E.coli expression system His Full Length (1-312)
Rattus norvegicus (Rat) RFL25964RF Recombinant Full Length Rat Estradiol 17-Beta-Dehydrogenase 12(Hsd17B12) Protein, His-Tagged E.coli expression system His Full Length (1-312)
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) RFL28877XF Recombinant Full Length Xenopus Tropicalis Estradiol 17-Beta-Dehydrogenase 12(Hsd17B12) Protein, His-Tagged E.coli expression system His Full Length (1-320)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HSD17B12 Related Articles

HSD17B12 involved in several pathways and played different roles in them. We selected most pathways HSD17B12 participated on our site, such as Fatty acid elongation, Steroid hormone biosynthesis, Biosynthesis of unsaturated fatty acids, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSD17B12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Fatty acid elongationELOVL4;ELOVL1B;PTPLA;TECRB;HADHA;ELOVL4A;TECR;HSD17B12;HSD17B12A
Steroid hormone biosynthesisCYP3A7-CYP3AP1;CYP2C70;SRD5A2A;UGT2B15;AKR1D1;CYP2C37;STS;HSD17B12;CYP3A65
Biosynthesis of unsaturated fatty acidsACOX3;ACOT1;HSD17B12A;BAAT;ELOVL2;PTPLAD2;HSD17B12B;FADS2;HADHA
Metabolic pathwaysIPMKB;B3GALT2;RPN1;LIPC;CYP2U1;NME2A;HK3;AMPD2;PLCH1
Fatty acid metabolismACSL4B;ACSL3;PTPLA;PPT1;SCD5;ACSL4;ACSBG2;MECR;ACADSB

HSD17B12 has several biochemical functions, for example, collagen binding, estradiol 17-beta-dehydrogenase activity, fibronectin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSD17B12 itself. We selected most functions HSD17B12 had, and list some proteins which have the same functions with HSD17B12. You can find most of the proteins on our site.

Function Related Protein
collagen bindingASPN;MTAP1A;CCBE1;SMAD7;LRRC15;VWF;ANTXR1;ITGA1;SMAD4
estradiol 17-beta-dehydrogenase activityAKR1B15;AKR1C6;H2-KE6;RDH8B;HSD17B12;HSD17B8;HSD17B6;HSD17B11;RDH8A
fibronectin bindingMFAP2;CTSL1;SFRP2;CTSK;VEGFA;IGFBP5B;SDC4;LRRC15;ITGA3
heparin bindingTHBS2;FMODA;APPB;RPL29;MMP7;SERPINA5;PCOLCE2;FGF4;APLP2
protein bindingRNF185;PDE6H;ANO6;ZBTB7A;NAT8B;KIAA1199;MTERF;VPS36;MTUS2

HSD17B12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSD17B12 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSD17B12.

UBQLN1; UBQLN1; vpu; CLN3; 1C; BECN1; P; HDAC11; SLC38A1

Li, Z; Van, LT; et al. Expression of enzymes involved in synthesis and metabolism of estradiol in human breast as studied by immunocytochemistry and in situ hybridization. HISTOLOGY AND HISTOPATHOLOGY 24:273-282(2009).
Brown, KA; Sayasith, K; et al. Molecular cloning of equine 17 beta-hydroxysteroid dehydrogenase type 1 and its downregulation during follicular luteinization in vivo. JOURNAL OF MOLECULAR ENDOCRINOLOGY 38:67-78(2007).
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