IBSP Protein, integrin-binding sialoprotein


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Official Full Name integrin-binding sialoprotein
Background The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor.
Synonyms integrin-binding sialoprotein; Cell-binding sialoprotein; BSP; BNSP; BSP-II; BSP II; SP-II; bone sialoprotein 2; Bone sialoprotein II; OTTHUMP00000161175; IBSP
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • Tag :
    • DDK
    • His
    • SUMO
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IBSP-1251H Recombinant Human IBSP Protein, His-SUMO-tagged E.coli His/SUMO
    Human IBSP-261H Recombinant Human IBSP, His-tagged CHO His
    Human IBSP-2710H Recombinant Human Integrin-binding Sialoprotein, His-tagged Human Cell His
    Human IBSP-2711H Recombinant Human Integrin-binding Sialoprotein, His-tagged CHO His
    Human IBSP-717H Recombinant Human IBSP Protein, DDK/His-tagged HEK293 DDK/His
    Human IBSP-718H Recombinant Human IBSP Protein, DDK/His-tagged HEK293 DDK/His
    Mouse Ibsp-600M Recombinant Mouse Ibsp Protein, His-tagged CHO His
    Mouse IBSP-7966M Recombinant Mouse IBSP Protein Mammalian Cell His
    Chicken IBSP-6718C Recombinant Chicken IBSP Mammalian Cell His

    IBSP involved in several pathways and played different roles in them. We selected most pathways IBSP participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with IBSP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    PIK-Akt signaling pathway LPAR5; ITGA1; GH1; PGF; IL7; FLT4; NFKB1; ANGPT4; ITGA7; PIK3R1
    Focal adhesion ACTN1; MYLK3; SHC4; ROCK2A; VAV2; FN1; LAMA5; PXNA; ITGA5; PAK2B
    ECM-receptor interaction ITGA6; VTNB; GP1BB; COL24A1; ITGA4; COL6A1; COL27A1; THBS3A; COL5A2A; GP9

    IBSP has several biochemical functions, for example, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by IBSP itself. We selected most functions IBSP had, and list some proteins which have the same functions with IBSP. You can find most of the proteins on our site.

    Function Related Protein
    molecular_function SMG8; KIF12; ZG16B; ASPSCR1; EYS; GM10395; TMEM263; DEFA3; Actl10; AND4

    IBSP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IBSP here. Most of them are supplied by our site. Hope this information will be useful for your research of IBSP.

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