IBSP
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Official Full Name
integrin-binding sialoprotein -
Overview
The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. -
Synonyms
integrin-binding sialoprotein;Cell-binding sialoprotein;BSP;BNSP;BSP-II;BSP II;SP-II;bone sialoprotein 2;Bone sialoprotein II;OTTHUMP00000161175;IBSP
Recombinant Proteins
- Human
- Mouse
- Chicken
- CHO
- E.coli
- Human Cells
- Mammalian Cells
- HEK293
- Insect Cells
- His
- SUMO
- Flag
- Avi
- Fc
Involved Pathway
IBSP involved in several pathways and played different roles in them. We selected most pathways IBSP participated on our site, such as PIK-Akt signaling pathway,Focal adhesion,ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with IBSP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PIK-Akt signaling pathway | IGF1R,FGF20,LPAR2,TNR,ITGB4,PRL,TRP53,FGF9,PDGFA,FGF11 |
| Focal adhesion | TLN2A,MYLPFA,PDPK1B,VCLA,AKT2L,MYLK,MYL9A,PIK3CG,PIK3R3A,CAV2 |
| ECM-receptor interaction | ITGA2,VTN,GP6,VTNA,LAMA1,COL11A1A,COL4A4,SV2A,COL4A5,ITGB8 |
Protein Function
IBSP has several biochemical functions, for example, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by IBSP itself. We selected most functions IBSP had, and list some proteins which have the same functions with IBSP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molecular_function | GVIN1,MSMB,TM9SF2,PPL,THSD7B,CEACAM10,TSPAN5A,GLOD5,MS4A4D,CCDC169 |
Interacting Protein
IBSP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IBSP here. Most of them are supplied by our site. Hope this information will be useful for your research of IBSP.
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