ICOSLG
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Official Full Name
inducible T-cell co-stimulator ligand
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Overview
Human B7-H2, also called B7RP-1, B7h, LICOS, and GL50, is a member of the growing B7 family of immune costimulatory proteins. Other family members include B7-1, B7-2, B7-H1 (PD-L1);, PD-L2, and B7-H3. B7 proteins are members of the immunoglobulin (Ig); su -
Synonyms
ICOSLG; inducible T-cell co-stimulator ligand; ICOSL; ICOS ligand; B7 homolog 2; B7 homologue 2; B7 H2; B7 related protein 1; B7H2; B7RP 1; B7RP1; CD275; GL50; ICOS L; KIAA0653; B7-like protein Gl50; B7-related protein 1; transmembrane protein B7-H2 ICOS ligand; B7-H2; LICOS; B7RP-1; ICOS-L;
- Recombinant Proteins
- Cell & Tissue Lysates
- GMP Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus
- Homo sapiens (Human)
- Human
- Monkey
- Mouse
- Rat
- Rhesus monkey
- CHO
- CHO cells
- E.coli
- E.coli expression system
- HEK293
- HEK293 cells
- HEK293T
- Human Cell
- Human cells
- Mammalian Cell
- Mammalian cells
- C
- His
- mFc
- 6×His
- DDK|His
- Fc
- Avi
- hFc
- hIgG1
- hIgG4
- His (Fc)
- His|T7
- human|IgG1|Fc
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- ICOSLG Related Articles
ICOSLG involved in several pathways and played different roles in them. We selected most pathways ICOSLG participated on our site, such as Cell adhesion molecules (CAMs), Intestinal i, ne network for IgA production, which may be useful for your reference. Also, other proteins which involved in the same pathway with ICOSLG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cell adhesion molecules (CAMs) | CADM1;OCLNA;CLDNJ;CDH15;CNTNAP2;HLA-DRB5;NRCAM;NCAM1;Itgam&Itgb2 |
Intestinal i | CCR10;BMA1;CXCR4B;HLA-DRB3;CD86;HLA-DPA1;Il2;MAP3K14;CD40 |
ne network for IgA production | MHC2DCB;CCL25B;BLB2;TGFB1A;HLA-DMA;CD28;HLA-DQA1;IL5;MHC2DAB |
ICOSLG has several biochemical functions, for example, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ICOSLG itself. We selected most functions ICOSLG had, and list some proteins which have the same functions with ICOSLG. You can find most of the proteins on our site.
Function | Related Protein |
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receptor binding | DPP4;F7;SEMA4D;ANGPTL2;EPHX2;KNG1;IAPP;LRP6;CD276 |
ICOSLG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ICOSLG here. Most of them are supplied by our site. Hope this information will be useful for your research of ICOSLG.
- Q&As
- Reviews
Q&As (6)
Ask a questionICOSLG protein plays an important regulatory role in the immune system. It binds to ICOS receptors on the surface of T cells and promotes the activation and differentiation of T cells, which in turn affects the strength and direction of the immune response.
Certain biomolecules can serve as molecular markers of ICOSLG proteins, such as mRNAs or proteins of ICOSLG proteins detected in biological samples such as blood and urine. These markers can be used for early diagnosis of disease, prognostic judgment, or monitoring of treatment efficacy.
Factors to be considered in drug development for ICOSLG proteins include drug specificity, safety, pharmacokinetic properties, etc. In addition, the dosage form, route of administration, and dosage of the drug need to be considered to develop an effective treatment plan.
A variety of factors can affect the expression of ICOSLG protein, including cytokines, inflammatory factors, immunostimulants, etc. These factors can stimulate or inhibit the expression of ICOSLG protein, which in turn affects the strength and direction of the immune response.
Therapeutic strategies targeting ICOSLG proteins include inhibition of its activity, modulation of its expression, and gene therapy. For example, the development of small molecule inhibitors or antibody drugs against ICOSLG protein to inhibit its aberrant activity in disease, or the regulation of ICOSLG protein expression through gene knockout or overexpression technology.
Assessing the potential of ICOSLG proteins as drug targets requires a comprehensive analysis. Factors to consider include the structure and function of the ICOSLG protein, its role in the immune system, interactions with existing medications, and potential therapeutic efficacy and safety.
Customer Reviews (3)
Write a reviewICOSLG performed very well in the experiments, with reliable and reproducible results.
The stability is very strong, and it can maintain the stability of its structure and function even after a lot of use, which shows its excellent quality and reliability.
The storage conditions are simple, and it will not be denatured even at ultra-low temperatures.
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