Recombinant Human ICOSLG Protein, His-tagged, Alexa Fluor 555 conjugated
Cat.No. : | ICOSLG-3213HAF555 |
Product Overview : | Alexa Fluor 555 conjugated recombinant human ICOSLG (Asp19-Ser258) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293). |
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Description : | ICOS ligand (ICOSLG) is also known as B7 homolog 2 (B7-H2), B7-related protein 1 (B7RP-1) and CD antigen CD275, which belongs to the immunoglobulin superfamily and BTN/MOG family. ICOSLG contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. Isoform 1 is widely expressed, while isoform 2 is detected only in lymph nodes, leukocytes and spleen. B7-H2 is ligand for the T-cell-specific cell surface receptor ICOS. B7-H2 acts as a costimulatory signal for T-cell proliferation and cytokine secretion and induces also B-cell proliferation and differentiation into plasma cells. B7-H2 could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Form : | Lyophilized |
Molecular Mass : | The protein has a calculated MW of 27.5 kDa. The protein migrates as 45-67 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | Asp19-Ser258 |
N-terminal Sequence Analysis : | Asp 19 |
Endotoxin : | < 1.0 EU/ μg by the LAL method. |
Purity : | > 95 % as determined by SDS-PAGE |
Characteristic : | Disulfide-linked homodimer Labeled with Alexa Fluor 555 via amines With an excitation and emission maximum of 555/565 nm, Alexa Fluor 555 can be efficiently excited using a 543 nm He-Ne laser line and detected under standard TRITC/Cy3 filters. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Storage Buffer : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 μg/μL. Centrifuge the vial at 4 centigrade before opening to recover the entire contents. |
Gene Name : | ICOSLG |
Official Symbol : | ICOSLG |
Synonyms : | ICOSLG; inducible T-cell co-stimulator ligand; ICOSL; ICOS ligand; B7 homolog 2; B7 homologue 2; B7 H2; B7 related protein 1; B7H2; B7RP 1; B7RP1; CD275; GL50; ICOS L; KIAA0653; B7-like protein Gl50; B7-related protein 1; transmembrane protein B7-H2 ICOS ligand; B7-H2; LICOS; B7RP-1; ICOS-L |
Gene ID : | 23308 |
mRNA Refseq : | NM_015259 |
Protein Refseq : | NP_056074 |
MIM : | 605717 |
UniProt ID : | O75144 |
Products Types
◆ Recombinant Protein | ||
ICOSLG-039H | Recombinant Human ICOSLG Protein, His-tagged | +Inquiry |
ICOSLG-794H | Recombinant Human ICOSLG Protein, MYC/DDK-tagged | +Inquiry |
ICOSLG-598H | Recombinant Human ICOSLG Protein | +Inquiry |
ICOSLG-90H | Recombinant Human ICOSLG Protein, His (Fc)-Avi-tagged | +Inquiry |
ICOSLG-540H | Active Recombinant Human ICOSLG, His-tagged | +Inquiry |
◆ Lysates | ||
ICOSLG-1095HCL | Recombinant Human ICOSLG cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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