Recombinant Human ICOSLG protein, His-Avi-tagged, Biotinylated

• Cat.No.: ICOSLG-144HB
• Product Overview: Biotinylated Recombinant Human B7-H2 Protein is expressed from Expi293 with a His and Avi Tag at the C-terminal. It contains Asp19-Ser258.

Specification

• Description: B7-H2, also known as B7-related protein (B7RP1), ICOS Ligand, and CD275, is an approximately 60 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. B7-H2 is a ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells.
• Source: HEK293
• Species: Human
• Tag: His-Avi
• Form: Supplied as 0.22μm filtered solution in PBS (pH 7.4).
• Molecular Mass: The protein has a predicted MW of 29.5 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on Bis-Tris PAGE result.
• Protein length: Asp19-Ser258
• Endotoxin: Less than 0.05 EU per μg by the LAL method.
• Purity: >95% as determined by Bis-Tris PAGE; >95% as determined by HPLC
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.

Gene Information

• Gene Name: ICOSLG
• Official Symbol: ICOSLG
• Synonyms: CD275 antigen; CD275; B7H2; B7-H2; B7H2B7 homolog 2; B7-H2B7-related protein 1; B7RP-1; B7RP1B7-like protein Gl50; B7RP-1LICOS; GL50; GL50transmembrane protein B7-H2 ICOS ligand; ICOSL; ICOS-L; ICOSLG; inducible T-cell co-stimulator ligand; KIAA0653ICOS ligand
• Gene ID: 23308
• mRNA Refseq: NM_001283050.2
• Protein Refseq: NP_001269979.1
• MIM: 605717
• UniProt ID: O75144