Recombinant Human ICOSLG Protein, His-tagged, FITC conjugated
Cat.No. : | ICOSLG-3213HF |
Product Overview : | FITC conjugated recombinant human ICOSLG (Asp19-Ser258) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293). |
Availability | September 20, 2024 |
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Description : | ICOS ligand (ICOSLG) is also known as B7 homolog 2 (B7-H2), B7-related protein 1 (B7RP-1) and CD antigen CD275, which belongs to the immunoglobulin superfamily and BTN/MOG family. ICOSLG contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. Isoform 1 is widely expressed, while isoform 2 is detected only in lymph nodes, leukocytes and spleen. B7-H2 is ligand for the T-cell-specific cell surface receptor ICOS. B7-H2 acts as a costimulatory signal for T-cell proliferation and cytokine secretion and induces also B-cell proliferation and differentiation into plasma cells. B7-H2 could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Form : | Lyophilized |
Molecular Mass : | The protein has a calculated MW of 27.5 kDa. The protein migrates as 45-67 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | Asp19-Ser258 |
N-terminal Sequence Analysis : | Asp 19 |
Endotoxin : | < 1.0 EU/ μg by the LAL method. |
Purity : | > 95 % as determined by SDS-PAGE |
Characteristic : | Disulfide-linked homodimer Labeled with FITC via amines Excitation source: 488 nm spectral line, argon-ion laser Excitation Wavelength: 488 nm Emission Wavelength: 535 nm |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Storage Buffer : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 μg/μL. Centrifuge the vial at 4 centigrade before opening to recover the entire contents. |
Gene Name : | ICOSLG |
Official Symbol : | ICOSLG |
Synonyms : | ICOSLG; inducible T-cell co-stimulator ligand; ICOSL; ICOS ligand; B7 homolog 2; B7 homologue 2; B7 H2; B7 related protein 1; B7H2; B7RP 1; B7RP1; CD275; GL50; ICOS L; KIAA0653; B7-like protein Gl50; B7-related protein 1; transmembrane protein B7-H2 ICOS ligand; B7-H2; LICOS; B7RP-1; ICOS-L |
Gene ID : | 23308 |
mRNA Refseq : | NM_015259 |
Protein Refseq : | NP_056074 |
MIM : | 605717 |
UniProt ID : | O75144 |
Products Types
◆ Recombinant Protein | ||
ICOSLG-3213HB | Recombinant Human ICOSLG protein(Met1-Ser258), His-tagged, Biotinylated | +Inquiry |
ICOSLG-039H | Recombinant Human ICOSLG Protein, His-tagged | +Inquiry |
ICOSLG-90H | Recombinant Human ICOSLG Protein, His (Fc)-Avi-tagged | +Inquiry |
ICOSLG-794H | Recombinant Human ICOSLG Protein, MYC/DDK-tagged | +Inquiry |
ICOSLG-598H | Recombinant Human ICOSLG Protein | +Inquiry |
◆ Lysates | ||
ICOSLG-1095HCL | Recombinant Human ICOSLG cell lysate | +Inquiry |
ICOSLG-2618MCL | Recombinant Mouse ICOSLG Overexpression Lysate(Met 1-Lys 279) | +Inquiry |
ICOSLG-2804MCL | Recombinant Mouse ICOSLG Overexpression Lysate(Met 1-Lys 279) | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewICOSLG performed very well in the experiments, with reliable and reproducible results.
The stability is very strong, and it can maintain the stability of its structure and function even after a lot of use, which shows its excellent quality and reliability.
The storage conditions are simple, and it will not be denatured even at ultra-low temperatures.
Q&As (6)
Ask a questionICOSLG protein plays an important regulatory role in the immune system. It binds to ICOS receptors on the surface of T cells and promotes the activation and differentiation of T cells, which in turn affects the strength and direction of the immune response.
Certain biomolecules can serve as molecular markers of ICOSLG proteins, such as mRNAs or proteins of ICOSLG proteins detected in biological samples such as blood and urine. These markers can be used for early diagnosis of disease, prognostic judgment, or monitoring of treatment efficacy.
Factors to be considered in drug development for ICOSLG proteins include drug specificity, safety, pharmacokinetic properties, etc. In addition, the dosage form, route of administration, and dosage of the drug need to be considered to develop an effective treatment plan.
A variety of factors can affect the expression of ICOSLG protein, including cytokines, inflammatory factors, immunostimulants, etc. These factors can stimulate or inhibit the expression of ICOSLG protein, which in turn affects the strength and direction of the immune response.
Therapeutic strategies targeting ICOSLG proteins include inhibition of its activity, modulation of its expression, and gene therapy. For example, the development of small molecule inhibitors or antibody drugs against ICOSLG protein to inhibit its aberrant activity in disease, or the regulation of ICOSLG protein expression through gene knockout or overexpression technology.
Assessing the potential of ICOSLG proteins as drug targets requires a comprehensive analysis. Factors to consider include the structure and function of the ICOSLG protein, its role in the immune system, interactions with existing medications, and potential therapeutic efficacy and safety.
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