ifnar1
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  • Official Full Name
  • interferon (alpha, beta and omega) receptor 1
  • Background
  • The antibody when prepared specifically for In vivo functional assays blocks type I IFN receptor signaling both In vitro and In vivo without depleting IFNAR1 bearing cells. This antibody was produced by In vivo genetic immunization of IFNAR1 knockout mice This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection.
  • Synonyms
  • IFNAR1; interferon (alpha, beta and omega) receptor 1; IFNAR; interferon alpha/beta receptor 1; IFRC; CRF2-1; IFN-R-1; IFN-alpha/beta receptor 1; interferon-beta receptor 1; beta-type antiviral protein; alpha-type antiviral protein; type I interferon rece; AVP; RF2-1; cytokine receptor class-II member 1; cytokine receptor family 2 member 1; human interferon-alpha receptor (HuIFN-alpha-Rec); IFN-alpha-REC; IFNBR; interferon-alpha/beta receptor alpha chain; nterferon-beta receptor 1; TTHUMP00000067672; FRC; type I interferon receptor 1
Cat.#:IFNAR1-001HTag:
Source (Host):NS0Species:Human
Product nameRecombinant Human IFNAR1 Protein
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Cat.#:IFNAR1-188HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human IFNAR1, Fc-tagged
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Cat.#:IFNAR1-28344THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human IFNAR1
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Cat.#:IFNAR1-29420THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human IFNAR1
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Cat.#:IFNAR1-508HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human IFNAR1 Protein, Fc-tagged
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Cat.#:IFNAR1-509HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IFNAR1 Protein, His-tagged
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Cat.#:IFNAR1-6938HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IFNAR1 protein, His-tagged
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Cat.#:IFNAR1-946HTag:His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human IFNAR1 Protein, His-tagged
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Cat.#:Ifnar1-3360MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ifnar1, His tagged
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Cat.#:Ifnar1-6939MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ifnar1 protein, His-tagged
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Cat.#:Ifnar1-6940RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ifnar1 protein, His-tagged
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Cat.#:IFNAR1-78CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IFNAR1, Fc tagged
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Cat.#:IFNAR1-80CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IFNAR1, LEVLFQ tagged
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Cat.#:IFNAR1-2205RTag:His
Source (Host):HEK293Species:Rhesus
Product nameRecombinant Rhesus IFNAR1 Protein, His-tagged
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Cat.#:IFNAR1-6422CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IFNAR1
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Cat.#:IFNAR1-1643HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IFNAR1 cell lysate
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Cat.#:IFNAR1-2372MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse IFNAR1 cell lysate
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Cat.#:IFNAR1-816CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IFNAR1 cell lysate
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Cat.#:IFNAR1-P004HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IFNAR1 therapeutic protein
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Involved Pathway

Ifnar1 involved in several pathways and played different roles in them. We selected most pathways Ifnar1 participated on our site, such as Cytokine-cytokine receptor interaction, PIK-Akt signaling pathway, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ifnar1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
BMPR1BB; CXCR6; Il2; TNFRSF11A; CD40LG; CXCL13; CRLF2; IFNA14; GHR; IL8L1
PIK-Akt signaling pathway
GNG5; Ifna11; Ifna15; EIF4E2; LAMA4; TCL1; ANGPT1; LPAR5; Fasl; FGF5
Osteoclast differentiation
CSF1R; GAB2; CYLD; BTK; LILRA5; IFNAR1; FCGR3; IL1A; TRAF2; MAPK8
Toll-like receptor signaling pathway
TLR4BB; AKT2; TICAM2; RAC1A; MAP2K6; IFNA5; IFNA13; IFNA3; IRAK1; Ifna15
Jak-STAT signaling pathway
FHL1A; SOCS1; IFNB; IFNA6; PIK3CG; AKT1; IL13RA2; RAF1B; EP300; CSF3
Natural killer cell mediated cytotoxicity
IFNA7; BRAF; FCGR3B; PLCG2; GM-CSF; KLRC3; Ifna11; SYK; KLRC1; GZMB
Hepatitis C
EIF2AK3; MAPK10; CLDN14; CLDN1; CLDN23; PIK3CA; CLDN7; NRAS; PIK3CG; KRAS
Hepatitis B
CASP9; STAT2; TNF; FAS; IFNA17; Casp3; FASLG; APAF1; TRP53; HRAS
Measles
IFNAR2; MX1; CD28; IFNGR2; Fasl; CBLB; CD209A; TNFRSF10D; CD209; AKT1
Influenza A
LOC100686744; IL8L1; MAVS; PRKCB; PIK3R3; HLA-DMA; CASP9; XPO1; HSPA1A; TNFRSF10A
Herpes simplex infection
BMA1; IFNA6; TNFRSF1A; PVRL2; TNFSF14; Ifna15; CFP; SP100; C3A.3; SRPK1A

Protein Function

Ifnar1 has several biochemical functions, for example, protein binding, type I interferon receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Ifnar1 itself. We selected most functions Ifnar1 had, and list some proteins which have the same functions with Ifnar1. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein AKT1S1; CC2D2A; DEFB121; KCTD17; ATF5; DAK; ATP6V1B2; WWTR1; RPS11; SCYL3
Function type I interferon receptor activity
Related Protein IFNAR1; IFNAR2

Interacting Protein

Ifnar1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ifnar1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ifnar1.
STAT2; FBXW11; IFNW1; TYK2; IFNAR2; EP300; q86up4_human; glpK

Ifnar1 Related Articles

Badr, BM; Moustafa, NA; et al. Increased Levels of Type 1 Interferon in a Type 1 Diabetic Mouse Model Induce the Elimination of B Cells from the Periphery by Apoptosis and Increase their Retention in the Spleen. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 35:137-147(2015).
Kuruganti, S; Accavitti-Loper, MA; et al. Production and characterization of thirteen human type-I interferon-alpha Mark subtypes. PROTEIN EXPRESSION AND PURIFICATION 103:75-83(2014).

Ifnar1 Related Gene Family

Cytokines