Recombinant Human IFNAR1 protein, His-Avi-tagged, Biotinylated

• Cat.No.: IFNAR1-181HB
• Product Overview: Biotinylated Human IFN-alpha/beta R1 Protein is expressed from mammalian with a His tag and Avi tag at the C-terminal. It contains Lys28-Lys436.

Specification

• Description: IFN-alpha / beta R1, also known as IFNAR1, belongs to the class II cytokine receptor family of proteins. Class II cytokine receptors form heterodimeric receptor complexes that mediate class II cytokine signals. Subunits of the different receptor complexes are shared and serve multiple functions.Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves.
• Source: HEK293
• Species: Human
• Tag: His-Avi
• Form: Supplied as 0.22um filtered solution in PBS (pH 7.4).
• Molecular Mass: The protein has a predicted MW of 50.2 kDa.Due to glycosylation, the protein migrates to 75-100KDa based on Bis-Tris PAGE result
• Protein length: It contains Lys28-Lys436.
• Endotoxin: Less than 0.1 EU per ug by the LAL method.
• Purity: > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: IFNAR1 interferon (alpha, beta and omega) receptor 1 [ Homo sapiens ]
• Official Symbol: IFNAR1
• Synonyms: Alpha-type antiviral protein; AVP; beta-type antiviral protein; CRF2-1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; human interferon-alpha receptor (HuIFN-alpha-Rec)10IFRC; IFN-alpha/beta R1; IFN-alpha/beta receptor 1; IFN-alpha-REC; IFNAR; IFNAR1; IFN-aR1; IFNBR; IFNbR1; IFN-bR1; IFN-R-1; interferon (alpha, beta and omega) receptor 1; interferon alpha/beta receptor 1; interferon-alpha/beta receptor alpha chain; interferon-beta receptor 1; Type I interferon receptor 1
• Gene ID: 3454
• mRNA Refseq: NM_000629
• Protein Refseq: NP_000620
• MIM: 107450
• UniProt ID: P17181