igfbp3
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  • Official Full Name
  • IGFBP3 insulin-like growth factor binding protein 3
  • Background
  • This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an;IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor;acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the;plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate;transcriptional splice variants, encoding different isoforms, have been characterized.
  • Synonyms
  • IGFBP3; insulin-like growth factor binding protein 3; insulin-like growth factor-binding protein 3; acid stable subunit of the 140 K IGF complex; binding protein 29; binding protein 53; BP 53; growth hormone dependent binding protein; IBP3; IGF binding protein 3; IBP-3; IGFBP-3; IGF-binding protein 3; growth hormone-dependent binding protein; BP-53
Cat.#:IGFBP3-14107HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IGFBP3, GST-tagged
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Cat.#:IGFBP3-26377THTag:
Source (Host):Species:Human
Product nameRecombinant Human IGFBP3
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Cat.#:IGFBP3-28257THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IGFBP3
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Cat.#:IGFBP3-489HTag:Met
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human IGFBP3, Met-tagged
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Cat.#:IGFBP3-758HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IGFBP3, His tagged
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Cat.#:IGFBP3-828HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IGFBP3 protein, His-tagged
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Cat.#:Igfbp3-7MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse IGFBP3, carrier free
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Cat.#:Igfbp3-829MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Igfbp3 protein, His-tagged
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Cat.#:Igfbp3-831RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Igfbp3 protein, His-tagged
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Cat.#:IGFBP3-8820CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IGFBP3, His tagged
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Cat.#:IGFBP3-2218RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IGFBP3 Protein, His-tagged
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Cat.#:IGFBP3-3732CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IGFBP3
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Cat.#:IGFBP3-11766ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IGFBP3
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Cat.#:IGFBP3-827CTag:His/T7
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle IGFBP3 protein, His & T7-tagged
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Cat.#:IGFBP3-830PTag:His/T7
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig IGFBP3 protein, His & T7-tagged
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Cat.#:IGFBP3-145HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Insulin-like Growth Factor Binding Protein 3
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Cat.#:IGFBP3-80HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Insulin-like Growth Factor Binding Protein 3
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Cat.#:IGFBP3-2716HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Insulin-Like Growth Factor Binding Protein 3
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Cat.#:Igfbp3-1750MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Insulin-like Growth Factor Binding Protein 3
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Cat.#:IGFBP3-2927HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IGFBP3 cell lysate
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Cat.#:IGFBP3-1230CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IGFBP3 cell lysate
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Cat.#:IGFBP3-197HTag:
Source (Host):E. coliSpecies:Human
Product nameInsulin-like growth Factor Binding Protein-3 Reference standard
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Involved Pathway

IGFBP3 involved in several pathways and played different roles in them. We selected most pathways IGFBP3 participated on our site, such as p signaling pathway, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGFBP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
p signaling pathway
GADD45B; COP1; APAF1; TNFRSF10B; CD82B; CCND2; CCNG2; GADD45AB; CDK1; SESN2
Transcriptional misregulation in cancer
SSX1; TRP53; ZBTB17; IL3; MLLT1; MLL1; HDAC2; FLT1; CD86; ATF1

Protein Function

IGFBP3 has several biochemical functions, for example, fibronectin binding, insulin-like growth factor I binding, insulin-like growth factor II binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGFBP3 itself. We selected most functions IGFBP3 had, and list some proteins which have the same functions with IGFBP3. You can find most of the proteins on our site.
Function
Related Protein
Function fibronectin binding
Related Protein LPA; LACRT; VEGFA; ITGA4; IGFBP5; SFRP2; ITGB1; CTSS; ITGAV; CTGF
Function insulin-like growth factor I binding
Related Protein IGFBP5A; IGFBP5; IGFBP2; IGFBP3; IGFBP1B; IGFBP6A; IGFBP2A; IGFBP1A; IGF1R; IGFBP6
Function insulin-like growth factor II binding
Related Protein IGFBP6B; IGFBP5B; IGFBP5; INSR; IGFBP2A; IGFBP5A; IGFBP4; IGFBP1A; IGFBP1B; IGFBP6
Function insulin-like growth factor binding
Related Protein IGFBP5B; IGFBP1A; DEFB126; IGFBP6A; IGFALS; WISP1B; IGFBP2B; KAZALD2; WISP3; HTRA1A
Function metal ion binding
Related Protein BLF; MMP23BB; PRKCD; CYP3A25; PDE6A; ZNF75A; PDLIM3B; PFKP; CRACR2B; ALPL
Function protein binding
Related Protein SKA3; PPP6R2; ZNF10; NMI; TAF8; FATE1; NEDD4L; RAB11B; IFT20; PFDN2
Function protein tyrosine phosphatase activator activity
Related Protein IGFBP3; PPP2R4

Interacting Protein

IGFBP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGFBP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGFBP3.
EGFR; PRKDC; AURKA; BUB1; KRAS; CCND1; BMPR1A; GTF3C1; POLA2; STK11; q8czf9_yerpe; dinB; FBXW7; MLH3; RAD54B

IGFBP3 Related Articles

Lariviere, N; Law, J; et al. Dissection of a Novel Autocrine Signaling Pathway via Quantitative Secretome and Interactome Mapping. JOURNAL OF PROTEOME RESEARCH 13:3432-3443(2014).
Moody, G; Beltran, PJ; et al. IGF1R blockade with ganitumab results in systemic effects on the GH-IGF axis in mice. JOURNAL OF ENDOCRINOLOGY 221:145-155(2014).