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IGFBP3

  • Official Full Name

    IGFBP3 insulin-like growth factor binding protein 3

  • Overview

    This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an;IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor;acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the;plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate;transcriptional splice variants, encoding different isoforms, have been characterized.
  • Synonyms

    IGFBP3; insulin-like growth factor binding protein 3; insulin-like growth factor-binding protein 3; acid stable subunit of the 140 K IGF complex; binding protein 29; binding protein 53; BP 53; growth hormone dependent binding protein; IBP3; IGF binding protein 3; IBP-3; IGFBP-3; IGF-binding protein 3; growth hormone-dependent binding protein; BP-53;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Chicken
  • Cynomolgus
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Pig
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • Rabbit
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Met
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IGFBP3-145H Active Recombinant Human Insulin-like Growth Factor Binding Protein 3 HEK293 N/A
Human IGFBP3-489H Active Recombinant Human IGFBP3, Met-tagged Mammalian cells Met
Human IGFBP3-28257TH Recombinant Human IGFBP3 E.coli N/A
Human IGFBP3-14107H Recombinant Human IGFBP3, GST-tagged E.coli GST 134-291a.a.
Human IGFBP3-2716H Recombinant Human IGFBP3 protein, His-tagged HEK293 His Gly28-Lys291
Human IGFBP3-828H Recombinant Human IGFBP3 protein, His-tagged E.coli His Gly135~Thr277 (Accession # P17936)
Human IGFBP3-80H Recombinant Human IGFBP3 protein E.coli N/A 264
Human IGFBP3-758H Recombinant Human IGFBP3, His tagged Human Cell His
Human IGFBP3-26377TH Recombinant Human IGFBP3 N/A
Human IGFBP3-2927HCL Recombinant Human IGFBP3 cell lysate Human Cell N/A
Human IGFBP3-110I Active Recombinant Human IGFBP3 Protein (264 aa) E.coli 264
Human CAB11559RH Rabbit Anti-Human IGFBP3 Monoclonal Antibody Rabbit N/A
Human IGFBP3-197H Insulin-like growth Factor Binding Protein-3 Reference standard E.coli N/A
Human IGFBP3-4260H Recombinant Human IGFBP3 Protein (Gly28-Lys291), N-His tagged Mammalian cells N-His Gly28-Lys291
Human IGFBP3-4353H Recombinant Human IGFBP3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IGFBP323022H Recombinant Human IGFBP3 Protein
Human IGFBP3-12H Recombinant Human IGFBP3 Protein (28-291aa), N-His-tagged E.coli N-His 28-291aa
Human IGFBP3-4353H-B Recombinant Human IGFBP3 Protein Pre-coupled Magnetic Beads HEK293
Human IGFBP3-1237H Recombinant Human IGFBP3 protein, His-tagged E.coli His/GST
Mouse Igfbp3-7M Active Recombinant Mouse IGFBP3, carrier free Mammalian cells N/A
Mouse Igfbp3-1750M Recombinant Mouse Insulin-like Growth Factor Binding Protein 3 Mammalian cells N/A
Mouse Igfbp3-829M Recombinant Mouse Igfbp3 protein, His-tagged E.coli His Ser151~Gln291 (Accession # P47878)
Mouse Igfbp3-1655M Recombinant Mouse Igfbp3 Protein, His-tagged E.coli N-His Val37-Gln292
Mouse Igfbp3-10570M Recombinant Mouse Igfbp3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Igfbp3-10570M-B Recombinant Mouse Igfbp3 Protein Pre-coupled Magnetic Beads HEK293
Rat Igfbp3-831R Recombinant Rat Igfbp3 protein, His-tagged E.coli His Asn137~Pro274
Cattle IGFBP3-827C Recombinant Cattle IGFBP3 protein, His & T7-tagged E.coli His/T7 Leu106~Asp241 (Accession # P20959)
Cynomolgus IGFBP3-8820C Active Recombinant Cynomolgus IGFBP3 protein, His-tagged HEK293 His Gly28-Lys291
Cynomolgus Monkey IGFBP3-1230CCL Recombinant Cynomolgus IGFBP3 cell lysate Human Cell N/A
Rhesus Macaque IGFBP3-2218R Recombinant Rhesus monkey IGFBP3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque IGFBP3-2039R-B Recombinant Rhesus Macaque IGFBP3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque IGFBP3-2039R Recombinant Rhesus Macaque IGFBP3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish IGFBP3-11766Z Recombinant Zebrafish IGFBP3 Mammalian Cell His
Pig IGFBP3-830P Recombinant Pig IGFBP3 protein, His & T7-tagged E.coli His/T7 Ser140~Gly271 (Accession # P16611)
Chicken IGFBP3-3732C Recombinant Chicken IGFBP3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • IGFBP3 Related Articles
  • IGFBP3 Related Research Area

IGFBP3 involved in several pathways and played different roles in them. We selected most pathways IGFBP3 participated on our site, such as p signaling pathway, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGFBP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
p signaling pathwayCASP3A;IGFBP3;SESN1;SERPINB5;RPRMA;PPM1DB;CCNB2;CCNB1;CCNE1
Transcriptional misregulation in cancerGOLPH3L;RXRG;GOLPH3;ETV6;MEIS1;ZEB1;CCNT1;HIST1H3A;TMPRSS2

IGFBP3 has several biochemical functions, for example, fibronectin binding, insulin-like growth factor I binding, insulin-like growth factor II binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGFBP3 itself. We selected most functions IGFBP3 had, and list some proteins which have the same functions with IGFBP3. You can find most of the proteins on our site.

Function Related Protein
fibronectin bindingIGFBP5B;MMP13;LRRC15;CTGF;CCDC80;SFRP2;MYOC;FBLN1;VEGFA
insulin-like growth factor I bindingIGFBP3;IGFBP4;IGFBP2A;IGFBP1B;IGFBP5A;IGFBP6B;IGFBP6;INSR;IGFBP5B
insulin-like growth factor II bindingIGFBP6A;IGFBP1A;IGFBP2A;IGFBP5;IGFBP2;IGFBP5A;IGFBP5B;IGFBP1B;IGFBP6B
insulin-like growth factor bindingESM1;IGFBP5B;IGF1R;IGF1RA;KAZALD2;HTRA3;HTRA3A;IGFBP7;HTRA4
metal ion bindingPLEKHF1;RUNX1T1;RASA4;EXTL2;ZFP637;FTH1B;PATZ1;PLA2G4AA;GIT2
protein bindingEIF4G2;PTGES3;PRDM13;SH3GL2;CPNE3;DNM1L;NKX2-1;SORBS2;SPI1B
protein tyrosine phosphatase activator activityPPP2R4;IGFBP3

IGFBP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGFBP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGFBP3.

EGFR; PRKDC; AURKA; BUB1; KRAS; CCND1; BMPR1A; GTF3C1; POLA2; STK11; q8czf9_yerpe; dinB; FBXW7; MLH3; RAD54B

Lariviere, N; Law, J; et al. Dissection of a Novel Autocrine Signaling Pathway via Quantitative Secretome and Interactome Mapping. JOURNAL OF PROTEOME RESEARCH 13:3432-3443(2014).
Moody, G; Beltran, PJ; et al. IGF1R blockade with ganitumab results in systemic effects on the GH-IGF axis in mice. JOURNAL OF ENDOCRINOLOGY 221:145-155(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there any genetic factors that influence IGFBP3 protein levels? 08/11/2022

Yes, genetic variations can affect IGFBP3 expression, potentially leading to differences in protein levels among individuals.

How does IGFBP3 protein influence bone health? 11/24/2021

IGFBP3 is involved in bone metabolism and is associated with bone mineral density. Low levels of IGFBP3 have been linked to decreased bone density and increased risk of fractures.

Are there any side effects associated with therapies targeting IGFBP3? 08/04/2021

The potential side effects of therapies targeting IGFBP3 are still being studied, and it varies depending on the specific treatment approach being used.

How do lifestyle factors such as diet and exercise influence IGFBP3 levels? 04/23/2021

Healthy lifestyle choices, including a balanced diet and regular exercise, can positively influence IGFBP3 levels, promoting overall health and reducing the risk of related diseases.

What are the implications of IGFBP3 deficiency in children's growth and development? 01/14/2021

IGFBP3 deficiency can impact children's growth and development, potentially leading to short stature and delayed puberty, as IGFBP3 is a key regulator of growth hormone actions.

Customer Reviews (3)

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Reviews
05/04/2020

    A manufacturer that offers customization options can enable the researcher to adhere to their experimental design requirements more effectively.

    01/20/2019

      A reliable manufacturer should be able to provide a consistently pure and high-quality IGFBP3 protein, ensuring that the samples are suitable for research purposes.

      01/02/2019

        This can help ensure compatibility between different components used in the trials and ease the overall experimental workflow.

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