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IGFBP4

  • Official Full Name

    insulin-like growth factor binding protein 4

  • Overview

    This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.
  • Synonyms

    IGFBP4; insulin-like growth factor binding protein 4; BP-4; IBP4; IGFBP-4; HT29-IGFBP; insulin-like growth factor-binding protein 4; IBP-4; IGF-binding protein 4; Insulin-like growth factor-binding protein 4;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Pig
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Yeast
  • C
  • His
  • Flag
  • His (Fc)
  • Avi
  • His|T7
  • Met
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IGFBP4-8H Active Recombinant Human IGFBP-4, Carrier Free Mammalian cells N/A
Human IGFBP4-191H Active Recombinant Human IGFBP4, Met-tagged Mammalian cells Met
Human IGFBP4-47H Recombinant Human IGFBP4 protein E.coli N/A
Human IGFBP4-5051H Recombinant Human IGFBP4 protein Insect Cell N/A 237
Human IGFBP4-2717H Recombinant Human Insulin-like Growth Factor Binding Protein 4 Yeast N/A
Human IGFBP4-614H Recombinant Human Insulin-like Growth Factor Binding Protein 4 E.coli N/A
Human IGFBP4-60H Recombinant Human IGFBP4 protein, T7/His-tagged E.coli T7/His
Human IGFBP4-832H Recombinant Human IGFBP4 protein, His-tagged E.coli His Asp22~Glu258 (Accession # P22692)
Human IGFBP4-759H Active Recombinant Human IGFBP4 protein, His-tagged HEK293 His Met1-Glu258
Human IGFBP4-205H Recombinant Human IGFBP4 protein, His-tagged HEK293 His Asp22-Glu258
Human IGFBP4-2926HCL Recombinant Human IGFBP4 cell lysate Human Cell N/A
Human IGFBP4-302H Recombinant Human IGFBP4 Protein, His-tagged HEK293 His 258
Human IGFBP4-2992H Recombinant Human IGFBP4 Protein (Asp22-Glu258), His tagged E.coli His Asp22-Glu258
Human IGFBP4-4429H-B Recombinant Human IGFBP4 Protein Pre-coupled Magnetic Beads HEK293
Human IGFBP4-1385H Recombinant Human IGFBP4 Protein Insect Cell N/A
Human IGFBP4-2991H Recombinant Human IGFBP4 Protein (Asp22-Glu258), C-His tagged Mammalian cells C-His Asp22-Glu258
Human IGFBP4-1389H Recombinant Human IGFBP4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human IGFBP4-755H Recombinant Human IGFBP4 protein HEK293 Glu99-Lys327
Human IGFBP4-1734H Recombinant Human IGFBP4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human IGFBP4-1416HFL Recombinant Full Length Human IGFBP4 Protein, C-Flag-tagged Mammalian cells Flag
Human IGFBP4-184I Active Recombinant Human IGFBP4 Protein, His-tagged HEK293 His
Human IGFBP4-4429H Recombinant Human IGFBP4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Igfbp4-833M Recombinant Mouse Igfbp4 protein, His & T7-tagged E.coli His/T7 Asp22~Glu254 (Accession # P47879)
Mouse IGFBP4-2925MCL Recombinant Mouse IGFBP4 cell lysate Human Cell N/A
Mouse Igfbp4-1228M Recombinant Mouse Igfbp4 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat IGFBP4-3009R Recombinant Rat IGFBP4 Protein Mammalian Cell His
Rat Igfbp4-1415R Recombinant Rat Insulin-Like Growth Factor Binding Protein 4 E.coli N/A
Rat Igfbp4-835R Recombinant Rat Igfbp4 protein, His & T7-tagged E.coli His/T7 Asp22~Glu254 (Accession # P21744)
Rat IGFBP4-2665R-B Recombinant Rat IGFBP4 Protein Pre-coupled Magnetic Beads HEK293
Rat IGFBP4-2665R Recombinant Rat IGFBP4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus IGFBP4-8819C Active Recombinant Cynomolgus IGFBP4 protein(Met1-Glu258), His-tagged HEK293 C-His Met1-Glu258
Cynomolgus Monkey IGFBP4-1231CCL Recombinant Cynomolgus IGFBP4 cell lysate Human Cell N/A
Rhesus Macaque IGFBP4-2219R Recombinant Rhesus monkey IGFBP4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque IGFBP4-2040R Recombinant Rhesus Macaque IGFBP4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque IGFBP4-2040R-B Recombinant Rhesus Macaque IGFBP4 Protein Pre-coupled Magnetic Beads HEK293
Pig IGFBP4-834P Recombinant Pig IGFBP4 protein, His & T7-tagged E.coli His/T7 Asp23~Glu259 (Accession # P24854)
Chicken IGFBP4-5924C Recombinant Chicken IGFBP4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • IGFBP4 Related Articles
  • IGFBP4 Related Research Area

IGFBP4 involved in several pathways and played different roles in them. We selected most pathways IGFBP4 participated on our site, such as Metabolism of proteins, Myometrial Relaxation and Contraction Pathways, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), which may be useful for your reference. Also, other proteins which involved in the same pathway with IGFBP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Metabolism of proteinsCCT7;EIF5;MPDU1A;PFDN5;GPR120;PPP6C;MUC15;TRAPPC3;CBX8
Myometrial Relaxation and Contraction PathwaysGUCA2B;ADM;ATF5;CNN2;GABPA;IGFBP2;GPR182;RGS6;RGS11
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)IGFBP5A;IGFBP6B;GZMH;IGFBP6A;PAPPA;IGFBP1A;IGFBP2;IGFBP1B;IGFBP6
Wnt signaling networkRYK;CTHRC1;IGFBP4;RSPO1;WIF1;ATP6AP2

IGFBP4 has several biochemical functions, for example, insulin-like growth factor I binding, insulin-like growth factor II binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGFBP4 itself. We selected most functions IGFBP4 had, and list some proteins which have the same functions with IGFBP4. You can find most of the proteins on our site.

Function Related Protein
insulin-like growth factor I bindingIGFBP5B;IGFBP2;IGFBP6;IGF1R;INSR;IGFBP4;IGFBP2A;IGFBP6A;IGFBP5
insulin-like growth factor II bindingIGFBP5A;IGFBP1A;IGFBP5;IGFBP5B;IGFBP2A;IGFBP6B;IGFBP3;IGFBP6A;IGFBP2

IGFBP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGFBP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGFBP4.

SUV39H1; KDM1A; q81l39_bacan

Khsheibun, R; Paperna, T; et al. Gene Expression Profiling of the Response to Interferon Beta in Epstein-Barr-Transformed and Primary B Cells of Patients with Multiple Sclerosis. PLOS ONE 9:-(2014).
Ivanov, VN; Ghandhi, SA; et al. Radiation response and regulation of apoptosis induced by a combination of TRAIL and CHX in cells lacking mitochondrial DNA: A role for NF-kappa B-STAT3-directed gene expression. EXPERIMENTAL CELL RESEARCH 317:1548-1566(2011).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
What role does IGFBP4 play in bone growth and development, particularly in regulating osteoblast and osteoclast activity? 09/09/2022

IGFBP4 plays a key role in bone development, regulating bone-forming and bone-resorbing cells.

What is the impact of IGFBP4 on cardiovascular health, particularly in atherosclerosis and heart disease? 04/30/2022

IGFBP4 impacts cardiovascular health, influencing atherosclerosis and heart disease processes.

What are the effects of IGFBP4 dysregulation on aging and age-related diseases? 10/08/2019

Dysregulation of IGFBP4 is linked to aging and the progression of age-related diseases.

How does IGFBP4 contribute to metabolic regulation and insulin sensitivity? 11/25/2018

IGFBP4 is involved in metabolic regulation, affecting insulin sensitivity and glucose metabolism.

How does IGFBP4 modulate the activity of insulin-like growth factors (IGFs) in various tissues? 10/23/2018

IGFBP4 modulates IGF activity, affecting growth and metabolic functions in tissues.

How do alterations in IGFBP4 expression or function affect wound healing and tissue repair? 07/09/2018

Changes in IGFBP4 expression influence wound healing and tissue repair mechanisms.

How does IGFBP4 influence cancer progression, especially in hormone-dependent cancers? 05/26/2018

IGFBP4 influences cancer progression, particularly in cancers sensitive to hormonal changes.

Customer Reviews (3)

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Reviews
02/25/2019

    Accurate protein structural analysis, crucial for our investigations.

    10/23/2018

      Exceptional protein expression optimization support, greatly appreciated.

      06/06/2018

        Reliable mass spectrometry analysis, pivotal for proteomics studies.

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