igfbp4
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  • Official Full Name
  • insulin-like growth factor binding protein 4
  • Background
  • This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.
  • Synonyms
  • IGFBP4; insulin-like growth factor binding protein 4; BP-4; IBP4; IGFBP-4; HT29-IGFBP; insulin-like growth factor-binding protein 4; IBP-4; IGF-binding protein 4; Insulin-like growth factor-binding protein 4
Cat.#:IGFBP4-1385HTag:
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human IGFBP4 Protein
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Cat.#:IGFBP4-1389HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IGFBP4 Protein, MYC/DDK-tagged
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Cat.#:Igfbp4-1415RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Insulin-Like Growth Factor Binding Protein 4
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Cat.#:IGFBP4-191HTag:Met
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human IGFBP4, Met-tagged
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Cat.#:IGFBP4-205HTag:His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human IGFBP4 Protein, His-tagged
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Cat.#:IGFBP4-47HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IGFBP4 protein
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Cat.#:IGFBP4-5051HTag:
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human IGFBP4 protein
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Cat.#:IGFBP4-60HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IGFBP4 protein, T7/His-tagged
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Cat.#:IGFBP4-759HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IGFBP4, His tagged
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Cat.#:IGFBP4-832HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IGFBP4 protein, His-tagged
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Cat.#:IGFBP4-8HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human IGFBP-4, Carrier Free
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Cat.#:Igfbp4-833MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Igfbp4 protein, His & T7-tagged
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Cat.#:IGFBP4-3009RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IGFBP4 Protein
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Cat.#:Igfbp4-835RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Igfbp4 protein, His & T7-tagged
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Cat.#:IGFBP4-8819CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IGFBP4, His tagged
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Cat.#:IGFBP4-2219RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IGFBP4 Protein, His-tagged
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Cat.#:IGFBP4-5924CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IGFBP4
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Cat.#:IGFBP4-834PTag:His/T7
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig IGFBP4 protein, His & T7-tagged
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Cat.#:IGFBP4-614HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Insulin-like Growth Factor Binding Protein 4
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Cat.#:IGFBP4-2717HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human Insulin-like Growth Factor Binding Protein 4
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Cat.#:IGFBP4-2926HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IGFBP4 cell lysate
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Cat.#:IGFBP4-2925MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse IGFBP4 cell lysate
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Cat.#:IGFBP4-1231CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IGFBP4 cell lysate
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Involved Pathway

IGFBP4 involved in several pathways and played different roles in them. We selected most pathways IGFBP4 participated on our site, such as Metabolism of proteins, Myometrial Relaxation and Contraction Pathways, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), which may be useful for your reference. Also, other proteins which involved in the same pathway with IGFBP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Metabolism of proteins
ADAMTSL4; IGFBP2; DNAJC24; MAGT1; MUCL1; MBOAT4; MUC1; YIF1A; DAD1; GNE
Myometrial Relaxation and Contraction Pathways
RGS20; ACTA1; MAFF; CORIN; IGFBP6; GUCA2B; RGS19; RGS18; RGS7; IGFBP5
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
IGFBP4; KLK13; IGFBP6; IGFBP2A; IGFBP1B; PAPPA2; IGFBP6B; IGFBP5; GZMH; IGF2B
Wnt signaling network
WIF1; CTHRC1; RYK; ATP6AP2; IGFBP4; RSPO1

Protein Function

IGFBP4 has several biochemical functions, for example, insulin-like growth factor I binding, insulin-like growth factor II binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGFBP4 itself. We selected most functions IGFBP4 had, and list some proteins which have the same functions with IGFBP4. You can find most of the proteins on our site.
Function
Related Protein
Function insulin-like growth factor I binding
Related Protein IGFBP2; IGFBP2A; IGFBP2B; IGFBP6A; IGFBP4; IGFBP3; IGFBP6B; IGFBP5A; IGFBP1A; IGFBP5
Function insulin-like growth factor II binding
Related Protein IGFBP5; IGFBP5B; IGFBP6A; INSR; IGFBP2B; IGFBP1B; IGFBP3; IGFBP6B; IGFBP2A; IGFBP5A

Interacting Protein

IGFBP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGFBP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGFBP4.
SUV39H1; KDM1A; q81l39_bacan

IGFBP4 Related Articles

Khsheibun, R; Paperna, T; et al. Gene Expression Profiling of the Response to Interferon Beta in Epstein-Barr-Transformed and Primary B Cells of Patients with Multiple Sclerosis. PLOS ONE 9:-(2014).
Ivanov, VN; Ghandhi, SA; et al. Radiation response and regulation of apoptosis induced by a combination of TRAIL and CHX in cells lacking mitochondrial DNA: A role for NF-kappa B-STAT3-directed gene expression. EXPERIMENTAL CELL RESEARCH 317:1548-1566(2011).