il12rb1
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  • Official Full Name
  • interleukin 12 receptor, beta 1
  • Background
  • The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor;superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12;receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The;coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and;reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the;immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript;variants of this gene encoding distinct isoforms have been reported.
  • Synonyms
  • IL12RB1; interleukin 12 receptor, beta 1; IL12RB; interleukin-12 receptor subunit beta-1; CD212; I12R1_HUMAN; IL-12 receptor beta component; IL-12 receptor subunit beta-1; IL-12R subunit beta-1; IL-12R-beta-1; IL-12RB1; IL12 receptor beta component; Interleukin 12 receptor beta 1 chain; Interleukin 12 receptor subunit beta 1; MGC34454; interleukin-12 receptor beta-1 chain; IL-12R-BETA1
Cat.#:IL12RB1-1733HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL12RB1 protein, His-tagged
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Cat.#:IL12RB1-3230HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL12RB1, His tagged
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Cat.#:IL12RB1-62HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human IL12RB1, His-tagged
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Cat.#:IL12RB1-8326HTag:
Source (Host):NS0Species:Human
Product nameRecombinant Human IL12RB1
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Cat.#:Il12rb1-1734MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il12rb1 protein, His & GST-tagged
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Cat.#:IL12RB1-8114MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IL12RB1 Protein
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Cat.#:Il12rb1-8337MTag:
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Il12rb1
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Cat.#:IL12RB1-1649HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Interleukin 12 Receptor, Beta 1
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Cat.#:IL12RB1-2188HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL12RB1 cell lysate
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Involved Pathway

IL12RB1 involved in several pathways and played different roles in them. We selected most pathways IL12RB1 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with IL12RB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CCR3; TGFBR1A; CXCR7; IFNGR1; CCL26; IL2RGA; BMP7A; INHBC; IFNA21; LEP
Jak-STAT signaling pathway
IFNA4; IFNK; IFNA21; IFNA7; IFNAR2; IL17D; GHR; IL6ST; PTPN2B; IL13RA1
Inflammatory bowel disease (IBD)
HLA-DRB1; IL4; TLR4; IL12A; GATA3; IL1B; TGFB3; IL2RG; IL12RB1; HLA-DMA

Protein Function

IL12RB1 has several biochemical functions, for example, cytokine receptor activity, contributes_to interleukin-12 receptor activity, contributes_to interleukin-12 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL12RB1 itself. We selected most functions IL12RB1 had, and list some proteins which have the same functions with IL12RB1. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine receptor activity
Related Protein CSF3R; LIFRA; IL12RB2; CRFB4; IL20RA; FLT3; IL20RB; F3B; CD74; IL15RA
Function contributes_to interleukin-12 receptor activity
Related Protein IL12RB1
Function contributes_to interleukin-12 receptor binding
Related Protein IL12RB1; IL23R; IL12B
Function contributes_to interleukin-23 binding
Related Protein IL23R; IL12RB1
Function contributes_to interleukin-23 receptor activity
Related Protein IL23R; IL12RB1

Interacting Protein

IL12RB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL12RB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL12RB1.
IL12A; IL12B; SNRPD3; il23a_il-12b_human

IL12RB1 Related Articles

Famulski, KS; Reeve, J; et al. Kidney Transplants With Progressing Chronic Diseases Express High Levels of Acute Kidney Injury Transcripts. AMERICAN JOURNAL OF TRANSPLANTATION 13:634-644(2013).
Tang, SW; Yang, TC; et al. Nicotinamide N-methyltransferase induces cellular invasion through activating matrix metalloproteinase-2 expression in clear cell renal cell carcinoma cells. CARCINOGENESIS 32:138-145(2011).

IL12RB1 Related Gene Family

IL