• Official Full Name
  • interleukin 26
  • Background
  • Interleukin 26 (IL-26) is a homodimer cytokine belonging to the IL-10 family that is expressed in certain herpesvirus-transformed T cells but IL-26 induces rapid phosphorylation of the transcription factors STAT1 and STAT3,Which enhance IL-10 and IL-8 secretion and as expression of the CD54 molecule on the surface of epithelial cells. IL-26's function in human disease is unknown, however research has found that IL-26 expression is up-regulated in active Crohn's disease, and therefore may play an active role along with Th17 cells in various autoimmune diseases.
  • Synonyms
  • IL26; interleukin 26; interleukin-26; AK155; IL 26; IL-26
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IL26 Protein (22-171 aa), His-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL26 Protein (22-171 aa), His-B2M-tagged
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IL26 Protein, GST-tagged
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IL26
Source (Host):Species:Human
Product nameRecombinant Human IL26 293 Cell Lysate

Involved Pathway

IL26 involved in several pathways and played different roles in them. We selected most pathways IL26 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL26 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
Ccl21a; Il23a; CCL24; CD70; PF4; Il6ra; VEGFAB; OSM; PRL; CXCR5

Protein Function

IL26 has several biochemical functions, for example, cytokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL26 itself. We selected most functions IL26 had, and list some proteins which have the same functions with IL26. You can find most of the proteins on our site.
Related Protein
Function cytokine activity
Related Protein Il23a; Il12b; TNFSF9; NAMPT; MIF; IL17A/F2; FAM3C; BMP8B; TIMP1; KITLG; IFNG

IL26 Related Articles

Skepner, J; Ramesh, R; et al. Pharmacologic Inhibition of ROR gamma t Regulates Th17 Signature Gene Expression and Suppresses Cutaneous Inflammation In Vivo. JOURNAL OF IMMUNOLOGY 192:2564-2575(2014).
Brand, S; et al. Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease. GUT 58:1152-1167(2009).