il28ra
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  • Official Full Name
  • interleukin 28 receptor alpha
  • Background
  • The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor;complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three;closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The;expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been;found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced;transcript variants encoding distinct isoforms have been reported.
  • Synonyms
  • IL28RA; interleukin 28 receptor alpha; interleukin-28 receptor subunit alpha; IL-28RA; IL-28R-alpha; IFN-lambda R1; IL-28 receptor subunit alpha; interferon lambda receptor 1; interferon-lambda receptor 1; class II cytokine receptor 12; cytokine receptor class-II member 12; cytokine receptor family 2 member 12; IFNLR1; CRF2-12
Cat.#:IL28RA-5201HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IL28RA Protein, GST-tagged
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Cat.#:IL28RA-49HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL28RA protein, GST-tagged
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Cat.#:IL28RA-5659HTag:Fc
Source (Host):NS0Species:Human
Product nameRecombinant Human Interleukin 28 Receptor, Alpha (interferon, lambda receptor), Fc-tagged
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Cat.#:IL28RA-841HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human IL28RA
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Cat.#:Il28ra-5658MTag:Fc
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Interleukin 28 Receptor Alpha, Fc-tagged
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Cat.#:IL28RA-601HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 28 Receptor, Alpha (interferon, lambda receptor)
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Involved Pathway

IL28RA involved in several pathways and played different roles in them. We selected most pathways IL28RA participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Type III interferon signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL28RA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
PDGFA; IFNGR2; CCR9A; IFNL3; CCL28; BMP7A; TNFRSF25; LEPA; IL20RA; IL4
Jak-STAT signaling pathway
IL29; PIK3CD; IL5RA; IL20; IFNA10; PIK3CG; HRASA; GRB2B; IL23R; AKT2L
Type III interferon signaling
IL28RA; IRX1; IL10RB

Protein Function

IL28RA has several biochemical functions, for example, cytokine receptor activity, contributes_to cytokine receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL28RA itself. We selected most functions IL28RA had, and list some proteins which have the same functions with IL28RA. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine receptor activity
Related Protein IL17RB; CD74; CRFB4; IL20RA; LIFRA; Il4ra; IL20RB; IL4R.1; F3B; FLT3
Function contributes_to cytokine receptor activity
Related Protein IL28RA; CD44; IRX1
Function protein binding
Related Protein DERL3; APTX; EIF4B; IMPDH2; CDK13; FDX1L; RHOT2; CHN1; CNIH2; SLC26A6

Interacting Protein

IL28RA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL28RA here. Most of them are supplied by our site. Hope this information will be useful for your research of IL28RA.
LSM8

IL28RA Related Articles

Egli, A; Santer, DM; et al. IL-28B is a Key Regulator of B- and T-Cell Vaccine Responses against Influenza. PLOS PATHOGENS 10:-(2014).