irf1
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  • Official Full Name
  • interferon regulatory factor 1
  • Background
  • IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion. [provided by RefSeq, Jul 2008]
  • Synonyms
  • IRF1; interferon regulatory factor 1; MAR; IRF-1; interferon regulatory factor 1 isoform d78;
Cat.#:IRF1-5046HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IRF1 Protein, GST-tagged
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Cat.#:IRF1-128HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IRF1 protein, MYC/DDK-tagged
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Cat.#:IRF1-243HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human IRF1
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Cat.#:IRF1-25HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human interferon regulatory factor 1, His-tagged
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Cat.#:IRF1-29246THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IRF1, His-tagged
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Cat.#:Irf1-7123MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Irf1 protein, His & GST-tagged
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Cat.#:IRF1-3096RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IRF1 Protein
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Cat.#:IRF1-2293RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IRF1 Protein, His-tagged
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Cat.#:IRF1-6966CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IRF1
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Cat.#:IRF1-5168HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IRF1 293 Cell Lysate
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Involved Pathway

IRF1 involved in several pathways and played different roles in them. We selected most pathways IRF1 participated on our site, such as Prolactin signaling pathway, Pertussis, Hepatitis C, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRF1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Prolactin signaling pathway
SOCS4; IRF1; SHC3; AKT1; ESR1; FOXO3; NFKB1; SOS1; CSN2; ESR2
Pertussis
C4BP; CXCL6; IRF3; GM5077; C5; IL23; C1S; Hc; MAPK9; IL1B
Hepatitis C
EIF2AK3; IKBKE; IRF3; CLDN9; CLDN18; STAT3; CLDN5; NFKBIA; RAF1; PIK3CD

Protein Function

IRF1 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRF1 itself. We selected most functions IRF1 had, and list some proteins which have the same functions with IRF1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein PHOX2BA; RBPJ; TBX22; ZFP521; ZNF529; NUCB2; ID2B; ETV5A; TOP1MT; ZNF615
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein ZNF257; CTCFL; TFE3A; KCNIP3; FOS; RELA; FLI1; GMEB1; MEF2B; JUND
Function protein binding
Related Protein FERD3L; HHLA3; FAM50B; ZFP64; RANGAP1; CISH; SPI1B; TSKS; KIAA0649; RAB11A
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein WT1; ETV2; FOSL1; CEBPB; TFAP2B; HOXA7; NFYC; ZFP639; CREB3L2; ONECUT3

Interacting Protein

IRF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRF1.
E7; 51094465; ULK2; E7; CDKN1B; QARS; foxp3_human_gene; ifnl1_human_gene

IRF1 Related Articles

Maruyama, S; Kanoh, M; et al. A novel function of interferon regulatory factor-1: inhibition of T(h)2 cells by down-regulating the Il4 gene during Listeria infection. INTERNATIONAL IMMUNOLOGY 27:143-152(2015).
Bake, V; Roesler, S; et al. Synergistic interaction of Smac mimetic and IFN alpha to trigger apoptosis in acute myeloid leukemia cells. CANCER LETTERS 355:224-231(2014).