|Official Full Name||interferon regulatory factor 1|
|Background||IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion. [provided by RefSeq, Jul 2008]|
|Synonyms||IRF1; interferon regulatory factor 1; MAR; IRF-1; interferon regulatory factor 1 isoform d78;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
IRF1 involved in several pathways and played different roles in them. We selected most pathways IRF1 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Prolactin signaling pathway||GRB2; AKT1; ELF5; MAP2K2; NFKB1; SIRPA; MAP2K1; SOCS3; SLC2A2; AKT2|
|Pertussis||IRF8; IL23; C4BPB; MAPK8; C1QA; TRAF6; SERPING1; C1QC; IRF1; Il23a; Il12b|
|Hepatitis C||PPP2R2A; BRAF; Ifna11; TNF; IKBKE; EIF2AK3; IFNA6; TNFRSF1A; RNASEL; NRAS|
IRF1 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by IRF1 itself. We selected most functions IRF1 had, and list some proteins which have the same functions with IRF1. You can find most of the proteins on our site.
|DNA binding||RARG; TAF6L; HIST2H2BE; ZNF652; ZFP541; NR2F5; SIX7; OTX1A; ZNF554; HMGXB4|
|RNA polymerase II core promoter proximal region sequence-specific DNA binding||NFYC; EN1; HAND1; GABPA; IFI203; MEF2B; DLX4; TP73; MZF1; NFIA|
|protein binding||PPIL2; EIF4EBP1; TAF1D; WWP1; FAM96A; POU1F1; SERINC1; HIPK2; HLTF; TARSL2|
|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding||SOX12; BCL11B; CEBPE; HOXA5; LEF1; DDIT3; MEF2C; PITX3; ZFP292; ESRRA|
IRF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRF1.
E7; 51094465; ULK2; E7; CDKN1B; QARS; foxp3_human_gene; ifnl1_human_gene