IRF8 Protein, interferon regulatory factor 8

IRF8

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IRF8

Official Full Name interferon regulatory factor 8
Background Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory;factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region;and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the;IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha;and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced;by viral infection.
Synonyms IRF8; interferon regulatory factor 8; interferon consensus sequence-binding protein; interferon consensus sequence binding protein 1; Myls; ICSBP; IRF-8; Icsbp1; AI893568
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • SUMO
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse IRF8-586M Recombinant Mouse IRF8 Protein (1-424 aa), His-SUMO-tagged E.coli His/SUMO
    Human IRF8-156H Recombinant Human IRF8, His-tagged E.coli His
    Human IRF8-5033H Recombinant Human IRF8 Protein, GST-tagged Wheat Germ GST
    Human IRF8-5159HCL Recombinant Human IRF8 293 Cell Lysate HEK293 N/A
    Mouse Irf8-1785M Recombinant Mouse Irf8 protein, His & T7-tagged E.coli His/T7
    Mouse IRF8-8306M Recombinant Mouse IRF8 Protein Mammalian Cell His
    Rhesus Macaque IRF8-2301R Recombinant Rhesus monkey IRF8 Protein, His-tagged Mammalian Cell His
    Chicken IRF8-6967C Recombinant Chicken IRF8 Mammalian Cell His
    Zebrafish IRF8-735Z Recombinant Zebrafish IRF8 Mammalian Cell His

    IRF8 involved in several pathways and played different roles in them. We selected most pathways IRF8 participated on our site, such as Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRF8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pertussis CALML3; NOS2; C1R; CD14; ITGB1; NFKB1; CASP7; C4BPA; C2; C1QC

    IRF8 has several biochemical functions, for example, protein binding, regulatory region DNA binding, transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRF8 itself. We selected most functions IRF8 had, and list some proteins which have the same functions with IRF8. You can find most of the proteins on our site.

    Function Related Protein
    protein binding HPGDS; DRG2; PRPF40A; HHIP; ZNF26; KRT6B; TCAP; SNX27; COL18A1; FAM71C
    regulatory region DNA binding IRF6; NFKB1; IRF5; IRF4A; IRF2A; IRF1A; IRF8; IRF1B; HMGA2; IRF3
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding USF1; MEIS1; FOXC1; SOX7; MYF5; ATF1; CIR1; NKX2-5; FOXC2; SOX9

    IRF8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRF8 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRF8.

    IRF6; flgK; q8d1m8_yerpe; MID1; CDK4; COPS2; GPS1; COPS6; COPS5; COPS4

    Bystrom, S; Ayoglu, B; et al. Affinity Proteomic Profiling of Plasma, Cerebrospinal Fluid, and Brain Tissue within Multiple Sclerosis. JOURNAL OF PROTEOME RESEARCH 13:4607-4619(2014).
    Battista, JM; Tallmadge, RL; et al. Hematopoiesis in the equine fetal liver suggests immune preparedness. IMMUNOGENETICS 66:635-649(2014).

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