irf8
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  • Official Full Name
  • interferon regulatory factor 8
  • Background
  • Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory;factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region;and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the;IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha;and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced;by viral infection.
  • Synonyms
  • IRF8; interferon regulatory factor 8; interferon consensus sequence-binding protein; interferon consensus sequence binding protein 1; Myls; ICSBP; IRF-8; Icsbp1; AI893568
Cat.#:IRF8-586MTag:His-SUMO
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse IRF8 Protein (1-424 aa), His-SUMO-tagged
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Cat.#:IRF8-5033HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IRF8 Protein, GST-tagged
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Cat.#:IRF8-156HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IRF8, His-tagged
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Cat.#:Irf8-1785MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Irf8 protein, His & T7-tagged
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Cat.#:IRF8-8306MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IRF8 Protein
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Cat.#:IRF8-2301RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IRF8 Protein, His-tagged
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Cat.#:IRF8-6967CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IRF8
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Cat.#:IRF8-735ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IRF8
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Cat.#:IRF8-5159HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IRF8 293 Cell Lysate
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Involved Pathway

IRF8 involved in several pathways and played different roles in them. We selected most pathways IRF8 participated on our site, such as Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRF8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Pertussis
Itgam&Itgb2; ITGB1; IRF3; MYD88; IL12B; Hc; NOS2; Il23a; Il12b; CALML3; ITGB2L

Protein Function

IRF8 has several biochemical functions, for example, protein binding, regulatory region DNA binding, transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRF8 itself. We selected most functions IRF8 had, and list some proteins which have the same functions with IRF8. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein KRT18; MUTED; NFE2; SEMA7A; PARP2; DNTT; SIK3; NTSR1; ARPC2; BPTF
Function regulatory region DNA binding
Related Protein IRF1B; NFKB1; IRF5; IRF4A; IRF6; IRF1A; IRF8; IRF2A; HMGA2; IRF3
Function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein POU3F1; PAX3; PROX1; IRF8; FOXC1; JUN; FOXP3; SOX17; PTH; FOXC2

Interacting Protein

IRF8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRF8 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRF8.
IRF6; flgK; q8d1m8_yerpe; MID1; CDK4; COPS2; GPS1; COPS6; COPS5; COPS4

IRF8 Related Articles

Bystrom, S; Ayoglu, B; et al. Affinity Proteomic Profiling of Plasma, Cerebrospinal Fluid, and Brain Tissue within Multiple Sclerosis. JOURNAL OF PROTEOME RESEARCH 13:4607-4619(2014).
Battista, JM; Tallmadge, RL; et al. Hematopoiesis in the equine fetal liver suggests immune preparedness. IMMUNOGENETICS 66:635-649(2014).