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IRF8

  • Official Full Name

    interferon regulatory factor 8

  • Overview

    Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory;factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region;and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the;IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha;and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced;by viral infection.
  • Synonyms

    IRF8; interferon regulatory factor 8; interferon consensus sequence-binding protein; interferon consensus sequence binding protein 1; Myls; ICSBP; IRF-8; Icsbp1; AI893568;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • His|T7
  • Myc
  • DDK
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IRF8-156H Recombinant Human IRF8, His-tagged E.coli His 121-426aa
Human IRF8-5159HCL Recombinant Human IRF8 293 Cell Lysate HEK293 N/A
Human IRF8-5033H Recombinant Human IRF8 Protein, GST-tagged Wheat Germ GST
Human IRF8-1201H-B Recombinant Human IRF8 Protein Pre-coupled Magnetic Beads HEK293
Human IRF8-4899H Recombinant Human IRF8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human IRF8-5742HF Recombinant Full Length Human IRF8 Protein, GST-tagged In Vitro Cell Free System GST 426 amino acids
Human IRF8-3094H Recombinant Human IRF8 Protein (Gly128-Val426), N-His tagged E.coli N-His Gly128-Val426
Human IRF8-1536HFL Recombinant Full Length Human IRF8 Protein, C-Flag-tagged Mammalian cells Flag
Human IRF8-1201H Recombinant Human IRF8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse IRF8-8306M Recombinant Mouse IRF8 Protein Mammalian Cell His
Mouse Irf8-1785M Recombinant Mouse Irf8 protein, His & T7-tagged E.coli His/T7 Met1~Arg327 (Accession # P23611)
Mouse IRF8-586M Recombinant Mouse IRF8 Protein (1-424 aa), His-SUMO-tagged E.coli His/SUMO 1-424 aa
Mouse Irf8-1206M Recombinant Mouse Irf8 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse IRF8-4606M Recombinant Mouse IRF8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse IRF8-4606M-B Recombinant Mouse IRF8 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque IRF8-2301R Recombinant Rhesus monkey IRF8 Protein, His-tagged Mammalian Cell His
Rhesus Macaque IRF8-2122R Recombinant Rhesus Macaque IRF8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque IRF8-2122R-B Recombinant Rhesus Macaque IRF8 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish IRF8-735Z Recombinant Zebrafish IRF8 Mammalian Cell His
Chicken IRF8-6967C Recombinant Chicken IRF8 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • IRF8 Related Articles
  • IRF8 Related Research Area

IRF8 involved in several pathways and played different roles in them. We selected most pathways IRF8 participated on our site, such as Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRF8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PertussisCASP7;CXCL5;C4BPB;IRAK4;GM5077;LY96;C4A;CALM3;C1S

IRF8 has several biochemical functions, for example, protein binding, regulatory region DNA binding, transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRF8 itself. We selected most functions IRF8 had, and list some proteins which have the same functions with IRF8. You can find most of the proteins on our site.

Function Related Protein
protein bindingRAB11A;TERF2IP;SNRNP70;GH1;TRIM27;WDR77;ZEB1;TMEM79;ATXN3
regulatory region DNA bindingIRF1A;HMGA2;IRF8;IRF3;IRF4A;IRF5;NFKB1;IRF6;IRF2A
transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingCEBPB;NR5A1;GATA5;NFATC1;PDX1;FOXF2A;POU3F1;PAX3;ZFHX3

IRF8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRF8 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRF8.

IRF6; flgK; q8d1m8_yerpe; MID1; CDK4; COPS2; GPS1; COPS6; COPS5; COPS4

Bystrom, S; Ayoglu, B; et al. Affinity Proteomic Profiling of Plasma, Cerebrospinal Fluid, and Brain Tissue within Multiple Sclerosis. JOURNAL OF PROTEOME RESEARCH 13:4607-4619(2014).
Battista, JM; Tallmadge, RL; et al. Hematopoiesis in the equine fetal liver suggests immune preparedness. IMMUNOGENETICS 66:635-649(2014).
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