itga2b
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  • Official Full Name
  • integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
  • Background
  • ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
  • Synonyms
  • ITGA2B; integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); GT; GTA; CD41; GP2B; HPA3; CD41B; GPIIb; BDPLT2; BDPLT16; integrin alpha-IIb; GPalpha IIb; platelet-specific antigen BAK; platelet membrane glycoprotein IIb; platelet fibrinogen receptor, alpha subunit;
Cat.#:ITGA2B-1425HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human ITGA2B Protein (639-887 aa), His-tagged
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Cat.#:ITGA2B-2615HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ITGA2B Protein, MYC/DDK-tagged
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Cat.#:ITGA2B-4999HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ITGA2B Protein, GST-tagged
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Cat.#:ITGA2B-174HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ITGA2B, GST-tagged
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Cat.#:ITGA2B-5758HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ITGA2B protein, His & T7-tagged
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Cat.#:ITGA2B-8348MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ITGA2B Protein
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Cat.#:ITGA2B-1144ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ITGA2B
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Cat.#:ITGA2B-10HTag:N/A
Source (Host):Species:Human
Product nameNative Human GPIIbIIIa
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Involved Pathway

ITGA2B involved in several pathways and played different roles in them. We selected most pathways ITGA2B participated on our site, such as Rap signaling pathway, PIK-Akt signaling pathway, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGA2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Rap signaling pathway
BRAF; ARAP3; PLCB4; NGF; FGF20; PFN3; APBB1IP; KIT; KRAS; FGF10
PIK-Akt signaling pathway
ITGB7; FGF13; TCL1B; FIGF; PRL; LPAR5; LAMA4; G6PC2; NFKB1; IFNA21
Focal adhesion
DOCK1; PTEN; MYL9A; FLNB; BAD; PPP1CBL; PAK7; PPP1CC; FYN; CCND3
ECM-receptor interaction
COL2A1A; COL6A1; SDC1; ITGA5; ITGA6B; GP5; ITGB6; ITGB3B; LAMC1; LAMA2
Platelet activation
GNAQ; PTGS1; P2RY12; FERMT3; FGA; SNAP23; MYLK3; PRKG2; ARHGAP35; ITGB3
Hematopoietic cell lineage
EPOR; MME; CD19; ITGB3; EPO; IL2RA; ITGA2; CD1D; FCGR1; CD1E
Regulation of actin cytoskeleton
ARHGEF12; CFL2L; FGF20B; ITGB1B.2; ROCK2A; FGF19; PAK2A; LIMK2; ARPC4L; FGD3
Pathways in cancer
LAMA1; PDGFRB; WNT6; PLCB1; NFKBIA; FOXO1; Shh; BCL2L1; TRAF4; SPI1
Small cell lung cancer
LAMA2; RXRG; CCNE2; LAMC2; LAMB1; LAMB3; CCNE1; PIK3CA; TRAF6; PIK3CB
Hypertrophic cardiomyopathy (HCM)
ITGAV; MYL3; TGFB3; ITGB3; SGCG; CACNG3; Itga10&Itgb1; ITGB1; ACE; TPM1
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
DAG1; SLC8A1; ITGA5; ITGA2; CTNNA1; ITGA2B; CTNNA2; SGCA; LMNA; CDH2
Dilated cardiomyopathy
TPM2; ITGA3; LAMA2; PRKACB; TNNC1; CACNA2D2; PRKACA; TPM3; CACNG8; RYR2

Protein Function

ITGA2B has several biochemical functions, for example, extracellular matrix binding, fibrinogen binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGA2B itself. We selected most functions ITGA2B had, and list some proteins which have the same functions with ITGA2B. You can find most of the proteins on our site.
Function
Related Protein
Function extracellular matrix binding
Related Protein FBLN2; VTN; VEGFA; GPR56; SID4; CYR61; BGN; ITGA2B; SPARC; SPOCK2
Function fibrinogen binding
Related Protein ITGA2B; MFAP2; FBLN1; THBS1
Function identical protein binding
Related Protein IGF2R; TNK2; S100A2; ALAD; GBP1; SEPHS1; SORD; BRAP; NOXO1; L1CAM
Function metal ion binding
Related Protein CH25HL2; PRDM12; HINFP; COL1A1; ZNF37A; ANTXR2; HDAC8; MORC1; TRIM35-30; ZNF277
Function protein binding
Related Protein HIST1H4H; DNMT1; TRAPPC3; FAM46A; LSM10; TGFB1I1; NDC80; FRMPD2; OGG1; TRIM25

Interacting Protein

ITGA2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGA2B here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGA2B.
ITGB3; g3gu78_crigr

ITGA2B Related Articles

Jin, Y; Wang, LM; et al. Differential expression of 5-HT-related genes in symptomatic pulmonary embolism patients. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 8:512-518(2015).
Nishikawa, S; Arai, S; et al. Thrombopoietin/MPL signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia. BLOOD 124:3587-3596(2014).