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ITGA2B

  • Official Full Name

    integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)

  • Overview

    ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
  • Synonyms

    ITGA2B; integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); GT; GTA; CD41; GP2B; HPA3; CD41B; GPIIb; BDPLT2; BDPLT16; integrin alpha-IIb; GPalpha IIb; platelet-specific antigen BAK; platelet membrane glycoprotein IIb; platelet fibrinogen receptor, alpha subunit;

  • Recombinant Proteins
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Macaca mulatta (Rhesus macaque)
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human plasma
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|T7
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ITGA2B-174H Recombinant Human ITGA2B, GST-tagged E.coli GST 678-894aa
Human ITGA2B-5758H Recombinant Human ITGA2B protein, His & T7-tagged E.coli His/T7 Gln891~Glu1039 (Accession # P08514)
Human ITGA2B-10H Native Human GPIIbIIIa Human plasma N/A
Human ITGA2B-2615H Recombinant Human ITGA2B Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ITGA2B-3124H Recombinant Human ITGA2B protein, His-SUMO-tagged E.coli His-SUMO 639-887aa
Human ITGA2B-2339H Recombinant Human ITGA2B Protein, His-tagged E.coli N-His Leu32-Val485
Human ITGA2B-4999H Recombinant Human ITGA2B Protein, GST-tagged Wheat Germ GST
Human ITGA2B-1152HFL Recombinant Full Length Human ITGA2B Protein, C-Flag-tagged Mammalian cells Flag
Human ITGA2B-1208H-B Recombinant Human ITGA2B Protein Pre-coupled Magnetic Beads HEK293
Human ITGA2B-1425H Recombinant Human ITGA2B Protein (639-887 aa), His-tagged Yeast His 639-887 aa
Human ITGA2B-1586H Recombinant Human ITGA2B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ITGA2B-1208H Recombinant Human ITGA2B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ITGA2B-0948H Recombinant Human ITGA2B Protein (Ala678-Leu894), N-His tagged E.coli N-His Ala678-Leu894
Human ITGA2B-4318H Recombinant Human ITGA2B Protein (Met1-Arg993), C-His tagged Mammalian cells C-His Met1-Arg993
Mouse ITGA2B-8348M Recombinant Mouse ITGA2B Protein Mammalian Cell His
Mouse ITGA2B-4635M Recombinant Mouse ITGA2B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ITGA2B-4635M-B Recombinant Mouse ITGA2B Protein Pre-coupled Magnetic Beads HEK293
Mouse Itga2b-3593M Recombinant Mouse Itga2b Protein, Myc/DDK-tagged HEK293T Myc/DDK
Macaca mulatta (Rhesus macaque) ITGA2B-5676M Recombinant Rhesus macaque ITGA2B Protein (Met52-Leu959), C-His tagged Mammalian cells C-His Met52-Leu959
Zebrafish ITGA2B-1144Z Recombinant Zebrafish ITGA2B Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ITGA2B Related Articles

ITGA2B involved in several pathways and played different roles in them. We selected most pathways ITGA2B participated on our site, such as Rap signaling pathway, PIK-Akt signaling pathway, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGA2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Rap signaling pathwayIGF1R;ANGPT2;GNAI3;RAF1;ANGPT1;FGF13;GNAQ;INSR;TEK
PIK-Akt signaling pathwayPKN3;HSP90AB1;LPAR2;ANGPT1;INSR;IL2RB;YWHAZ;SGK3;TEK
Focal adhesionRAP1AB;SRC;PIK3CD;MYL5;PPP1CC;LAMA5;LAMA1;PARVAA;RAC3
ECM-receptor interactionCOMP;ITGA6;ITGA2B;ITGA1;DAG1;COL6A2;COL27A1B;GP1BB;COL5A1
Platelet activationITGA2B;COL27A1;MYLK3;SNAP23;BTK;PLA2G4D;STIM1;MAPK1;PRKACA
Hematopoietic cell lineageKIT;CR2;IL2RA;CD7;FCER2;GP1BB;CD19;ITGA5;GYPA
Regulation of actin cytoskeletonITGB3B;CHRM5A;MYL2B;PIP4K2C;FGF7;PAK2B;Pdgfa&Pdgfb;VCL;MAP2K2A
Pathways in cancerARAF;STAT5B;FGF12;BAD;FGFR3;FZD10;RALGDS;TRAF2;RARA
Small cell lung cancerFHIT;RB1;ITGA6;CASP9;ITGA3;LAMB1;TRAF4;AKT1;LAMB2
Hypertrophic cardiomyopathy (HCM)ITGB8;ITGA2;PRKAA1;ITGA7;EMD;ITGAV;DAG1;LAMA2;ITGA4
Arrhythmogenic right ventricular cardiomyopathy (ARVC)CTNNA1;SGCG;ITGA6;ITGB1;ACTN1;SLC8A1;CACNG1;ITGB8;ITGA2
Dilated cardiomyopathyDES;ITGA4;CACNG7;ITGB4;RYR2;CACNG2;ITGB3;CACNB2;PLN

ITGA2B has several biochemical functions, for example, extracellular matrix binding, fibrinogen binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGA2B itself. We selected most functions ITGA2B had, and list some proteins which have the same functions with ITGA2B. You can find most of the proteins on our site.

Function Related Protein
extracellular matrix bindingSPP1;GPR56;FBLN2;CYR61;SPOCK2;ITGAV;VTN;SID4;CD248
fibrinogen bindingMFAP2;ITGA2B;FBLN1;THBS1
identical protein bindingNOXO1;RAF1;KCNH2;PSMD4;ZNF703;DAPK2;DRD4;CLDN11;USP2
metal ion bindingSDHD;ASXL2;ATP2C1;GLI1;ZFP609;PPP5C;HDDC3;ZKSCAN6;TRIM35-34
protein bindingFRMD6;KLF11;DHDDS;MAX;RAD51D;ATG5;VIM;KIAA0101;KCNRG

ITGA2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGA2B here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGA2B.

ITGB3; g3gu78_crigr

Jin, Y; Wang, LM; et al. Differential expression of 5-HT-related genes in symptomatic pulmonary embolism patients. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 8:512-518(2015).
Nishikawa, S; Arai, S; et al. Thrombopoietin/MPL signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia. BLOOD 124:3587-3596(2014).
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