ITGA6
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Official Full Name
integrin, alpha 6
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Overview
The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ITGA6; integrin, alpha 6; integrin alpha-6; CD49f; integrin alpha6B; CD49 antigen-like family member F; VLA-6; ITGA6B; FLJ18737; DKFZp686J01244;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rhesus Macaque
- CHO
- E. coli
- E.coli
- HEK293
- HEK293T
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- Flag
- Flag|His
- GST
- His (Fc)
- Avi
- His|Avi
- His|GST
- Myc
- DDK
- Myc|DDK
- N/A
- N
- His6ABP
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ITGA6-4110H | Active Recombinant Human ITGA6 | CHO | N/A |
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| Human | ITGA6&ITGB1-608H | Active Recombinant Human ITGA6&ITGB1 | CHO | N/A |
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| Human | ITGA6-609H | Active Recombinant Human ITGA6 | CHO | N/A |
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| Human | ITGA6-4111H | Recombinant Human ITGA6, GST-tagged | Wheat Germ | GST | 24 a.a. - 133 a.a. |
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| Human | ITGA6-4115H | Recombinant Human ITGA6, flag & His tagged | Human Cell | Flag/His | ||
| Human | ITGA6 & ITGB1-1878HCL | Recombinant Human ITGA6 & ITGB1 cell lysate | Human Cell | N/A |
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| Human | ITGA6-5131HCL | Recombinant Human ITGA6 293 Cell Lysate | HEK293 | N/A |
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| Human | ITGA6 & ITGB1-609H | Recombinant Human ITGA6 & ITGB1 Protein, His-Avi-tagged, Biotinylated | HEK293 | His/Avi | ||
| Human | ITGA6-2612H | Recombinant Human ITGA6 Protein, MYC/DDK-tagged | HEK293 | Myc/DDK |
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| Human | ITGA6-4315H | Recombinant Human ITGA6 Protein (Met1-Arg938), C-His tagged | Mammalian cells | C-His | Met1-Arg938 |
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| Human | ITGA6-4314H | Recombinant Human ITGA6 Protein (Met1-Ser1050), C-His tagged | Mammalian cells | C-His | Met1-Ser1050 |
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| Human | ITGA6-1218H | Recombinant Human ITGA6 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK |
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| Human | ITGA6 & ITGB1-102H | Recombinant Human ITGA6 & ITGB1 protein, His-Avi-tagged | HEK293 | His-Avi | lt contains Phe24-Gly1012 (P23229-2) acidic tail& GIn21-His 728 (P05556)basic tail design. |
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| Human | ITGA6 & ITGB4-610H | Recombinant Human ITGA6 & ITGB4 protein, Flag/His-tagged | HEK293 | Flag/His | ITGA6 (Met1-Ser1011) & ITGB4 (Met1-Ser710) |
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| Human | ITGA6-2700H | Recombinant Human ITGA6 protein(621-730 aa), C-His-tagged | E. coli | C-His | 621-730 aa |
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| Human | ITGA6-5725HF | Recombinant Full Length Human ITGA6 Protein | In Vitro Cell Free System | 420 amino acids |
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| Human | ITGA6-4995H | Recombinant Human ITGA6 Protein | Wheat Germ | N/A |
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| Human | ITGA6-06H | Recombinant Human ITGA6 Protein, N-His6ABP tagged | E.coli | N-His6ABP |
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| Human | ITGA6-3016H | Recombinant Human ITGA6 protein, His-tagged | E.coli | His | 477-690 aa | |
| Human | ITGA6-2342H | Recombinant Human ITGA6 Protein, His-tagged | E.coli | N-His | Phe24-Asn478 |
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| Mouse | Itga6-6767M | Recombinant Mouse Itga6 protein, His & GST-tagged | E.coli | His/GST | Glu903~Ala1073 (Accession # Q61739) |
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| Mouse | Itga6-1698M | Recombinant Mouse Itga6 Protein, His-tagged | E.coli | N-His | Phe24-Asn479 |
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| Mouse | Itga6-3597M | Recombinant Mouse Itga6 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Mouse | Itga6-1699M | Recombinant Mouse Itga6 Protein, His-tagged | E.coli | N-His | Arg480-Arg899 |
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| Rhesus Macaque | ITGA6-2314R | Recombinant Rhesus monkey ITGA6 Protein, His-tagged | Mammalian Cell | His |
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| Rhesus Macaque | ITGA6-2135R | Recombinant Rhesus Macaque ITGA6 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rhesus Macaque | ITGA6-2135R-B | Recombinant Rhesus Macaque ITGA6 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Chicken | ITGA6-6841C | Recombinant Chicken ITGA6 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- ITGA6 Related Articles
- ITGA6 Related Research Area
ITGA6 involved in several pathways and played different roles in them. We selected most pathways ITGA6 participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGA6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PIK-Akt signaling pathway | ITGA8;FOXO3;TCL1B;INS1;HSP90AB1;IGF1;THBS3;PDGFRB;PKN1 |
| Focal adhesion | MYL12.1;ITGB5;PPP1R12B;MAPK1;PXN;ACTN2;HRASB;AKT3A;PIK3R5 |
| ECM-receptor interaction | THBS3A;COL6A6;LAMA4;COL4A2;CHAD;COL5A2A;COL4A4;IBSP;COL6A1 |
| Cell adhesion molecules (CAMs) | CD6;PTPRC;CLDN4;PVRL2;CDH1;SDC1;ITGA8;PVRL3;MAG |
| Hematopoietic cell lineage | CD3E;CD5;HLA-DRB3;EPOR;FLT3LG;IL11RA;IL3;FCGR1A;Kitl |
| Regulation of actin cytoskeleton | CFL2;RAC2;PIK3CG;RHOAC;FGF7;PAK6B;FGF8A;ITGAX;PIP5K2 |
| Toxoplasmosis | MAPK1;HLA-DOB;HLA-DMB;PIK3CA;IFNGR2;LDLR;CD40;TYK2;PDPK1 |
| Pathways in cancer | XIAP;FGFR2;GLI2;TRAF5;GNGT1;EPAS1;TCEB1;WNT9B;AGTR1B |
| Small cell lung cancer | LAMC1;ITGA6;NFKBIA;LAMC2;CASP9;FHIT;RELA;MAX;COL4A1 |
| Hypertrophic cardiomyopathy (HCM) | ACTB;CACNG8;TNNC1;CACNG3;PRKAA2;ATP2A2;TNF;PRKAG3;TGFB2 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ACTN4;ITGA6;CTNNA1;ITGA1;SGCG;CACNB4;ITGAV;EMD;ITGB6 |
| Dilated cardiomyopathy | TGFB2;ITGA2B;PRKACB;CACNA2D2;ITGB7;TGFB1;DAG1;ITGAV;ITGB6 |
ITGA6 has several biochemical functions, for example, integrin binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGA6 itself. We selected most functions ITGA6 had, and list some proteins which have the same functions with ITGA6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| integrin binding | COL5A1;LAMA5;ICAM3;ACTN1;WISP1A;ADAM25;TSPAN8;EDIL3;ITGB1BP2 |
| metal ion binding | THRAA;ELAC1;PRPSAP2;MUSK;PDE12;MORC2B;PM20D1.1;PARP12A;MLPH |
| protein binding | STX1A;EIF4G2;PIBF1;C14orf135;RPS19BP1;Siglec1;DOCK1;COX8A;TGFB1I1 |
ITGA6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGA6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGA6.
ITGB4; PDIA3; ITGB1; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; Itgb1; CD9
- Q&As
- Reviews
Q&As (6)
Ask a questionThe expression level of ITGA6 protein can be detected by immunohistochemistry, western blotting, and real-time PCR.
Aberrant expression of ITGA6 protein can promote the adhesion and migration of cancer cells, thereby contributing to the development and metastasis of cancer. High expression of ITGA6 is often associated with the degree of malignancy and poor prognosis of the cancer.
There are some challenges and controversies in the current research on ITGA6 protein, including its specific mechanism of action in different diseases, its interaction with other molecules, and the optimal treatment. In addition, more clinical data is needed to validate the reliability of ITGA6 protein as a biomarker.
Due to its critical role in a variety of diseases, ITGA6 protein may become an important target for drug discovery. Drugs targeting the ITGA6 protein may have the potential to treat diseases such as cancer, fibrotic diseases, and inflammatory diseases.
At present, targeted therapies targeting ITGA6 protein are still in the research stage, and there are no drugs approved for clinical use. However, some studies are exploring the use of antibodies or small molecule inhibitors to block the function of ITGA6 to treat related diseases.
Some studies have shown that the expression level of ITGA6 protein can serve as a biomarker for the prognosis and treatment response of certain cancers. However, more studies are needed to verify its clinical application value.
Customer Reviews (3)
Write a reviewI've used this several times and their performance has been consistent and I've never had a problem.
It is very suitable for crystallography research.
It has good antigenicity and can induce a target immune response.
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