itga6
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  • Official Full Name
  • integrin, alpha 6
  • Background
  • The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • ITGA6; integrin, alpha 6; integrin alpha-6; CD49f; integrin alpha6B; CD49 antigen-like family member F; VLA-6; ITGA6B; FLJ18737; DKFZp686J01244
Cat.#:ITGA6 & ITGB1-609HTag:His-Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human ITGA6 & ITGB1 Protein, His-Avi-tagged, Biotinylated
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Cat.#:ITGA6-2612HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ITGA6 Protein, MYC/DDK-tagged
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Cat.#:ITGA6-4995HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ITGA6 Protein
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Cat.#:ITGA6&ITGB1-608HTag:
Source (Host):CHO cellsSpecies:Human
Product nameRecombinant Human ITGA6&ITGB1
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Cat.#:ITGA6-4110HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human ITGA6
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Cat.#:ITGA6-4111HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human ITGA6, GST-tagged
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Cat.#:ITGA6-4115HTag:Flag/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ITGA6, flag & His tagged
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Cat.#:ITGA6-609HTag:
Source (Host):CHO cellsSpecies:Human
Product nameRecombinant Human ITGA6
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Cat.#:Itga6-6767MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Itga6 protein, His & GST-tagged
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Cat.#:ITGA6-2314RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ITGA6 Protein, His-tagged
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Cat.#:ITGA6-6841CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ITGA6
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Cat.#:ITGA6 & ITGB1-1878HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human ITGA6 & ITGB1 cell lysate
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Cat.#:ITGA6-5131HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ITGA6 293 Cell Lysate
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Involved Pathway

ITGA6 involved in several pathways and played different roles in them. We selected most pathways ITGA6 participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGA6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
PIK-Akt signaling pathway
TSC1; BCL2L1; PIK3R2; ANGPT2; PTEN; FGF10; RAC1; FIGF; FGF16; IFNA6
Focal adhesion
PIP5K1C; LAMB3; Pdgfa&Pdgfb; GRB2A; PPP1CA; ELK1; PGF; ACTN1; MYL12.1; PPP1CAB
ECM-receptor interaction
CD36; COL24A1; TNC; SV2C; ITGA5; COL11A1A; COL27A1B; COL1A1; ITGA3; THBS4B
Cell adhesion molecules (CAMs)
NCAM1A; BMA1; CLDN18; HLA-A; ICAM2; MAG; CLDNB; BMA2; OCLNB; CLDN15
Hematopoietic cell lineage
CSF1; CD1E, B2M; FCER2; CD22; CD3E; CD3D; KITLG; HLA-DRB1; IL5; IL11; EPOR
Regulation of actin cytoskeleton
RAC1B; MOS; PIP5K1BB; RRAS; BAIAP2A; GIT1; MAP2K2; RHOAB; ABI2A; Fgf15
Toxoplasmosis
HLA-DMA; AKT2; HLA-DQB1; MAPK9; MAPK8; HLA-DPA1; LAMB1; MAP2K6; CD40LG; SOCS1
Pathways in cancer
GNG4; VEGFA; MAPK9; MAP2K1; FADD; PTCH2; GNAI3; SUFU; TPM3; PTGER4
Small cell lung cancer
AKT1; TRAF2; RXRG; RARB; CCND1; IKBKG; CCNE2; TRAF4; CYCS; BIRC2
Hypertrophic cardiomyopathy (HCM)
SGCD; TNNI3; TGFB2; CACNG6; ITGB1; CACNB3; TGFB1; MYL2; PRKAG1; ATP2A2
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
ITGB6; ITGA10; CDH2; ITGAV; SGCA; ITGB3; ACTN2; CACNA2D1; DSG2; CACNA2D3
Dilated cardiomyopathy
ITGB4; GNAS; CACNA2D4; TNNI3; ITGA4; CACNB2; TNF; DMD; CACNG4; RYR2

Protein Function

ITGA6 has several biochemical functions, for example, integrin binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGA6 itself. We selected most functions ITGA6 had, and list some proteins which have the same functions with ITGA6. You can find most of the proteins on our site.
Function
Related Protein
Function integrin binding
Related Protein ICAM1; NOV; ACTN4; THBS4; WISP1B; VCAM1; ADAM25; TNN; NF2; VTN
Function metal ion binding
Related Protein LMO7A; HIVEP2A; ZFP593; DHX57; DDHD1; CDC7; ZMYND17; ZBTB12.2; GUCA1G; ZRANB3
Function protein binding
Related Protein RAI1; KRTAP10-11; SH2D2A; CTF1; DAB1; RBMX2; EIF3G; MASP1; NOXO1; ELAVL1

Interacting Protein

ITGA6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGA6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGA6.
ITGB4; PDIA3; ITGB1; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; Itgb1; CD9

ITGA6 Related Articles

Landowski, TH; Gard, J; et al. Targeting Integrin alpha 6 Stimulates Curative-Type Bone Metastasis Lesions in a Xenograft Model. MOLECULAR CANCER THERAPEUTICS 13:1558-1566(2014).
Kwon, J; Lee, TS; et al. Integrin alpha 6: A novel therapeutic target in esophageal squamous cell carcinoma. INTERNATIONAL JOURNAL OF ONCOLOGY 43:1523-1530(2013).