jak1
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  • Official Full Name
  • Janus kinase 1
  • Background
  • Members of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3, and Tyk2) are activated by ligands binding to a number of associated cytokine receptors. Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their a
  • Synonyms
  • JAK1; Janus kinase 1; JAK1B; tyrosine-protein kinase JAK1; JAK1A; JTK3
Cat.#:JAK1-1941HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human JAK1 Protein (850-1154 aa), His-tagged
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Cat.#:JAK1-674HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Janus Kinase 1, GST-tagged
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Cat.#:JAK1-159HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human JAK1 protein, His/MBP-tagged
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Cat.#:JAK1-160HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human JAK1 protein, His/MBP-tagged
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Cat.#:JAK1-18HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human JAK1 protein, GST-tagged
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Cat.#:JAK1-249HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human JAK1
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Cat.#:JAK1-28HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human JAK1 protein, MYC/DDK-tagged
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Cat.#:JAK1-56HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human JAK1 protein, Flag-tagged, Biotinylated
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Cat.#:JAK1-670HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human JAK1, GST-tagged
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Cat.#:Jak1-7876MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Jak1 protein, His & T7-tagged
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Cat.#:JAK1-2326RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey JAK1 Protein, His-tagged
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Cat.#:JAK1-6433CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken JAK1
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Cat.#:JAK1-8699ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish JAK1
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Cat.#:JAK1-5107HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human JAK1 293 Cell Lysate
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Involved Pathway

JAK1 involved in several pathways and played different roles in them. We selected most pathways JAK1 participated on our site, such as ARMS-mediated activation, Antiviral mechanism by IFN-stimulated genes, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with JAK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ARMS-mediated activation
SPRED2; JAK2; DUSP2; DUSP7; DUSP5; SPNA1; KBTBD7; PEA15; EGFR; MARK3
Antiviral mechanism by IFN-stimulated genes
USP18; EIF4E3; MX2; EIF4EB; ARIH1L; EIF4G1; EIF4A1; EIF4G2; NUP50; NUP35
Axon guidance
AP2M1; EPHB4A; DAB2IPB; AP2B1; COL6A2; ARPC2; CD24; EFNB3; LOC608458; DNM1
Cytokine Signaling in Immune system
IFIT2; FGF8B; MAP3K8; TRIM68; WDR83; IFIT8; TNFSF13B; IFIT11; ISG20; SAMHD1
DAP12 interactions
SPNA2; FGFR1B; SIRPB1; FGF20A; WDR83; SPRED1; TREM1; GRAP2B; ADRBK1; CNKSR1
DAP12 signaling
GRAP2B; FRS2A; HBEGF; GRAP2A; LCP2A; PTPRA; DUSP5; DUSP1; PRKAR1AA; PEBP1
Developmental Biology
EVL; ADAM22; PTPRA; LGI2B; DLG3; AP2S1; LGI1; ARPC2; SCN9A; DUSP2
Downstream signal transduction
LAMTOR2; FGF20A; KBTBD7; AGO1; SPTBN2; SPRED2; SPNA1; FRS3; FGFR1B; JAK1

Protein Function

JAK1 has several biochemical functions, for example, ATP binding, CCR5 chemokine receptor binding, growth hormone receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by JAK1 itself. We selected most functions JAK1 had, and list some proteins which have the same functions with JAK1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PRKACA; MAP3K12; NLRP10; KIF14; NOLC1; AKT1; MYHC4; ATP6V1BA; HKDC1; CLPXA
Function CCR5 chemokine receptor binding
Related Protein CCL3; STAT3; CCL4; CCL5; JAK1; CNIH4
Function growth hormone receptor binding
Related Protein TYK2; JAK2; GH1; JAK1; SOCS2; Gh
Function non-membrane spanning protein tyrosine kinase activity
Related Protein PTK2B; BTK; TYK2; FYNB; SYK; TXK; TNK2; PTK2BB; ZNF143B; FRK
Function protein binding
Related Protein DDI1; XRCC1; NLRP3; DOCK9; TRIM24; LIN7A; C3orf52; ABL1; OPRK1; JUNB
Function protein phosphatase binding
Related Protein PPP6R1; VRK3; TP53; CDC27; VCP; ANAPC5; FGF19; DLG4; CSF1R; JAK1
Function protein tyrosine kinase activity
Related Protein JAK3; ERBB3B; NTRK2B; HCK; EPHB2; FGFR1OP; DYRK1B; TESK2; CAMKK2; FGFR4
Function ubiquitin protein ligase binding
Related Protein YWHAZ; MAGEA2; MC1R; SUMO1; PIAS1; HSPA1B; CUL3B; TNFRSF1B; UBE2KB; UBE2C

Interacting Protein

JAK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with JAK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of JAK1.
IFNAR2; STAM2; ERBB2; Dlg4; P; v_rindsa; HSP90AB1; IL6R; PRKCA; BRCA1; P/V; V

JAK1 Related Articles

Cianciulli, A; Dragone, T; et al. IL-10 plays a pivotal role in anti-inflammatory effects of resveratrol in activated microglia cells. INTERNATIONAL IMMUNOPHARMACOLOGY 24:369-376(2015).
Kubo, S; Yamaoka, K; et al. The JAK inhibitor, tofacitinib, reduces the T cell stimulatory capacity of human monocyte-derived dendritic cells. ANNALS OF THE RHEUMATIC DISEASES 73:2192-2198(2014).

JAK1 Related Gene Family

TGF Cytokines