Active Recombinant Human JAK1 Protein, Flag tagged

• Cat.No.: JAK1-19H
• Product Overview: Recombinant JAK1 (866-1154) protein that includes amino acids 866-1154 of human JAK1 protein (accession number NP_001307852.1) was expressed in a baculovirus expression system, and contains an N-terminal FLAG tag.

Specification

• Species: Human
• Source: Insect Cells
• Tag: Flag
• Protein Length: 866-1154 aa
• Description: This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta, interferon-gamma, and cytokine signal transduction. This gene plays a crucial role in effecting the expression of genes that mediate inflammation, epithelial remodeling, and metastatic cancer progression. This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The kinase activity of this gene is directly inhibited by the suppressor of cytokine signalling 1 (SOCS1) protein. Alternative splicing results in multiple transcript variants.
• Form: Supplied in 25 mM HEPESNaOH pH 7.5, 300 mM NaCl, 10% glycerol, 0.04% Triton X-100, and 0.5 mM TCEP.
• Molecular Mass: 34.2 kDa
• Purity: > 95%
• Storage: Recombinant proteins in solution are temperature sensitive and must be stored at -80 centigrade to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
• Concentration: 0.2 μg/μL

Gene Information

• Gene Name: JAK1 Janus kinase 1 [ Homo sapiens (human) ]
• Official Symbol: JAK1
• Synonyms: JAK1; Janus kinase 1; JTK3; AIIDE; JAK1A; JAK1B; tyrosine-protein kinase JAK1; EC 2.7.10.2
• Gene ID: 3716
• mRNA Refseq: NM_001320923
• Protein Refseq: NP_001307852
• MIM: 147795
• UniProt ID: P23458