kat2a
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  • Official Full Name
  • K(lysine) acetyltransferase 2A
  • Background
  • KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also;functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA;(MIM 164014) in a HAT-independent manner (Mao et al., 2009 (PubMed 19339690)).
  • Synonyms
  • KAT2A; K(lysine) acetyltransferase 2A; GCN5 general control of amino acid synthesis 5 like 2 (yeast) , GCN5L2; histone acetyltransferase KAT2A; GCN5; PCAF b; STAF97; hsGCN5; lysine acetyltransferase 2A; histone acetyltransferase GCN5; general control of a
Cat.#:KAT2A-1017HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KAT2A, His-tagged
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Cat.#:KAT2A-120HTag:GST
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human KAT2A Protein, GST-tagged
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Cat.#:KAT2A-121HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human KAT2A Protein, His-tagged
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Cat.#:KAT2A-18HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KAT2A Protein, GST-tagged
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Cat.#:KAT2A-2129HTag:His
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human K(lysine) Acetyltransferase 2A, His-tagged
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Cat.#:KAT2A-2132HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human KAT2A protein, GST-tagged
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Cat.#:KAT2A-274HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human KAT2A, His-tagged
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Cat.#:KAT2A-29886THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KAT2A, His-tagged
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Cat.#:KAT2A-1392HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human KAT2A (Active), GST-tagged
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Cat.#:KAT2A-290HCLTag:Myc/DDK
Source (Host):Human HEK293T cell lineSpecies:Human
Product nameRecombinant Human KAT2A HEK293T cell lysate
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Involved Pathway

KAT2A involved in several pathways and played different roles in them. We selected most pathways KAT2A participated on our site, such as Notch signaling pathway, Thyroid hormone signaling pathway, HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with KAT2A were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Notch signaling pathway
PTCRA; ADAM17; DLL1; DLA; MYCBP; DTX4; MFAP5; HER9; NOTCH1B; DTX3
Thyroid hormone signaling pathway
KRAS; MAPK3; HRAS; PIK3R2; KAT2B; ATP1B4; NCOA1; PIK3CA; THRB; SRC
HTLV-I infection
PIK3R3; XIAP; RANBP1; BUB3; Adcy4; ETS2; LTA; XBP1; TP53; ANAPC4
Viral carcinogenesis
PXN; SCRIB; PSMC1; HDAC4; GTF2H3; HLA-F; HIST1H4D; SND1; HRAS; HIST1H2BK

Protein Function

KAT2A has several biochemical functions, for example, H3 histone acetyltransferase activity, chromatin binding, histone acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KAT2A itself. We selected most functions KAT2A had, and list some proteins which have the same functions with KAT2A. You can find most of the proteins on our site.
Function
Related Protein
Function H3 histone acetyltransferase activity
Related Protein KAT2A; ELP3; BRCA2
Function chromatin binding
Related Protein TOX4; TRIM37; HIF1AB; TFAM; TCF7; SP140L; HDAC4; CTBP2; STAG1; LDB1
Function histone acetyltransferase activity
Related Protein EP300; TAF1; vnc; HTATIP; KAT7A; KAT2B; TAF1L; NCOA2; NCOA1; METTL8
Function contributes_to histone acetyltransferase activity
Related Protein SUPT7L; TADA2B; ING3; TAF5L; TADA1; TAF9; TAF6L; SUPT3H; TEX30; TAF10
Function histone acetyltransferase activity (H4-K12 specific)
Related Protein KAT2A
Function histone deacetylase binding
Related Protein HDAC6; NACC2; KPNA2; CCND1; RELA; RUNX2; KAT2B; USF1; SKOR2; HOXA10
Function protein binding
Related Protein KAZN; COPG; CPNE1; CRHR2; SIRPG; SKAP1; GFM2; DGCR8; GABPB1; ILF3
Function protein phosphatase binding
Related Protein PPP1R3C; CSK; ROS1; STAT6; VCP; PIK3R1; HSP90B1; SHOC2; MET; KAT2A
Function transcription coactivator activity
Related Protein PRDM16; ARL2BP; WNT3A; TAF7L; NR1I3; MED27; ENY2; CBFB; MTDH; RB1
Function transcription factor binding
Related Protein STK4; PER1; SMAD2; TRIM11; GATA4; DIP2B; NFATC2; ETS1; CTNNB1; PIAS1

Interacting Protein

KAT2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KAT2A here. Most of them are supplied by our site. Hope this information will be useful for your research of KAT2A.
TRRAP; WDHD1; ATXN7; BRCA1