Recombinant Human KAT2A protein, GST-tagged

• Cat.No.: KAT2A-2132H
• Product Overview: Recombinant Human KAT2A(1 a.a. - 837 a.a.) fused with GST tag at N-terminal was expressed in Wheat Germ.

Specification

• Description: KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Form: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
• Molecular Mass: 118.47 kDa
• AA Sequence: MAEPSQAPTPAPAAQPRPLQSPAPA PTPTPAPSPASAPIPTPTPAPAPAP AAAPAGSTGTGGPGVGSGGAGSGGD PARPGLSQQQRASQRKAQVRGLPRA KKLEKLGVFSACKANETCKCNGWKN PKPPTAPRMDLQQPAANLSELCRSC EHPLADHVSHLENVSEDEINRLLGM VVDVENLFMSVHKEEDTDTKQVYFY LFKLLRKCILQMTRPVVEGSLGSPP FEKPNIEQGVLNFVQYKFSHLAPRE RQTMFELSKMFLLCLNYWKLETPAQ FRQRSQAEDVATYKVNYTRWLCYCH VPQSCDSLPRYETTHVFGRSLLRSI FTVTRRQLLEKFRVEKDKLVPEKRT LILTHFPKFLSMLEEEIYGANSPIW ESGFTMPPSEGTQLVPRPASVSAAV VPSTPIFSPSMGGGSNSSLSLDSAG AEPMPGEKRTLPENLTLEDAKRLRV MGDIPMELVNEVMLTITDPAAMLGP ETSLLSANAARDETARLEERRGIIE FHVIGNSLTPKANRRVLLWLVGLQN VFSHQLPRMPKEYIARLVFDPKHKT LALIKDGRVIGGICFRMFPTQGFTE IVFCAVTSNEQVKGYGTHLMNHLKE YHIKHNILYFLTYADEYAIGYFKKQ GFSKDIKVPKSRYLGYIKDYEGATL MECELNPRIPYTELSHIIKKQKEII KKLIERKQAQIRKVYPGLSCFKEGV RQIPVESVPGIRETGWKPLGKEKGK ELKDPDQLYTTLKNLLAQIKSHPSA WPFMEPVKKSEAPDYYEVIRFPIDL KTMTERLRSRYYVTRKLFVADLQRV IANCREYNPPDSEYCRCASALEKFF YFKLKEGGLIDK
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name: KAT2A K(lysine) acetyltransferase 2A [ Homo sapiens ]
• Official Symbol: KAT2A
• Synonyms: KAT2A; K(lysine) acetyltransferase 2A; GCN5 general control of amino acid synthesis 5 like 2 (yeast) , GCN5L2; histone acetyltransferase KAT2A; GCN5; PCAF b; STAF97; hsGCN5; lysine acetyltransferase 2A; histone acetyltransferase GCN5; general control of amino acid synthesis protein 5-like 2; General control of amino acid synthesis, yeast, homolog-like 2; GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2; hGCN5; GCN5L2; PCAF-b; MGC102791
• Gene ID: 2648
• mRNA Refseq: NM_021078
• Protein Refseq: NP_066564
• MIM: 602301
• UniProt ID: Q92830
• Chromosome Location: 17q12-q21
• Pathway: C-MYC pathway, organism-specific biosystem; E2F transcription factor network, organism-specific biosystem; Gene expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystem;
• Function: H3 histone acetyltransferase activity; chromatin binding; histone acetyltransferase activity; contributes_to histone acetyltransferase activity; histone acetyltransferase activity (H4-K12 specific); histone deacetylase binding; protein binding; transcription coactivator activity; transferase activity