krt8
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  • Official Full Name
  • keratin 8
  • Background
  • This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
  • Synonyms
  • KRT8; keratin 8; K8; KO; CK8; CK-8; CYK8; K2C8; CARD2; keratin, type II cytoskeletal 8; cytokeratin 8; cytokeratin-8; type-II keratin Kb8;
Cat.#:KRT8-4835HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human KRT8 Protein, GST-tagged
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Cat.#:KRT8-145HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KRT8, His-tagged
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Cat.#:KRT8-178HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant human KRT8
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Cat.#:KRT8-561HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human keratin 8, His-tagged
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Cat.#:KRT8-8855MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse KRT8 Protein
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Cat.#:Krt8-2123RTag:His/S
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Krt8 protein, His & S-tagged
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Cat.#:Krt8-2124RTag:His/S
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Krt8 protein, His & S-tagged
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Cat.#:KRT8-3332RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat KRT8 Protein
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Cat.#:KRT8-2448RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey KRT8 Protein, His-tagged
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Cat.#:KRT8-10433ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish KRT8
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Cat.#:KRT8-1247HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Keratin 8
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Cat.#:KRT8-144HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Keratin 8
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Cat.#:KRT8-177BTag:
Source (Host):Species:Bovine
Product nameNative bovine KRT8
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Cat.#:KRT8-4862HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human KRT8 293 Cell Lysate
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Cat.#:CSC-P0656Tag:
Source (Host):Species:Human
Product nameAnti-Human KRT8 MAb Stable Cell Line-CHO
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Cat.#:CSC-P0657Tag:
Source (Host):Species:Human
Product nameAnti-Human KRT8 F(ab) Stable Cell Line-CHO
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Cat.#:CSC-P0658Tag:
Source (Host):Species:Human
Product nameAnti-Human KRT8 scFv Stable Cell Line-CHO
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Involved Pathway

KRT8 involved in several pathways and played different roles in them. We selected most pathways KRT8 participated on our site, such as EGFR1 Signaling Pathway, Signaling mediated by p38-alpha and p38-beta, which may be useful for your reference. Also, other proteins which involved in the same pathway with KRT8 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
EGFR1 Signaling Pathway
STXBP1A; ABI1; ABI1B; REPS1; KRT17; RGS16; SH3BGRL; CRKL; GRB14; KRT8
Signaling mediated by p38-alpha and p38-beta
HBP1; GDI1; USF1; KRT8

Protein Function

KRT8 has several biochemical functions, for example, protein binding, protein complex binding, scaffold protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KRT8 itself. We selected most functions KRT8 had, and list some proteins which have the same functions with KRT8. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein ATP5B; PPM1K; GOLGA1; KRT83; GTF3C4; SMC6; DBNL; C11orf57; DTL; LCORL
Function protein complex binding
Related Protein PCSK2; VAMP2; SHANK1; DISC1; CEBPA; GNB2; CDKN1A; PPFIA2; ATF1; FYB
Function scaffold protein binding
Related Protein MAPK3; CIT; MAP2K2; PANX1; KRT5; SHANK1; NLRP1; NOS3; CASP8; TREM2
Function structural molecule activity
Related Protein MAP4; CYT1; KRT18; KRT38; FGA; KRT42; CLDN15B; SPRR2E; ADD1; NGS

Interacting Protein

KRT8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KRT8 here. Most of them are supplied by our site. Hope this information will be useful for your research of KRT8.
KRT18; CFTR; p27958-pro_0000037566

KRT8 Related Articles

Zhou, Y; Hu, ZQ; et al. Genome-Wide Demethylation by 5-aza-2 '-Deoxycytidine Alters the Cell Fate of Stem/Progenitor Cells. STEM CELL REVIEWS AND REPORTS 11:87-95(2015).
Bunel, A; Jorssen, EP; et al. Individual bovine in vitro embryo production and cumulus cell transcriptomic analysis to distinguish cumulus-oocyte complexes with high or low developmental potential. THERIOGENOLOGY 83:228-237(2015).