lat
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  • Official Full Name
  • linker for activation of T cells
  • Background
  • Linker for activation of T cells (LAT) is a 36 kDa transmembrane adapter protein that is tyrosine- phosphorylated following T-cell receptor (TCR) stimulation by ZAP-70 and Syk. Four distal tyrosine residues (#132, #171, #191 and #226 in human LAT) are cru
  • Synonyms
  • LAT; linker for activation of T cells; linker for activation of T-cells family member 1; LAT1; transmembrane adaptor; p36-38; 36 kDa phospho-tyrosine adapter protein; 36 kDa phospho-tyrosine adaptor protein; linker for activation of T cells, transmembrane adaptor; pp36
Cat.#:LAT-29047THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LAT, His-tagged
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Cat.#:LAT-335HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LAT Protein, His-tagged
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Cat.#:LAT-6882HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Linker For Activation Of T Cells, His-tagged
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Cat.#:Lat-336MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Lat Protein, His-tagged
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Cat.#:LAT-8969MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse LAT Protein
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Cat.#:LAT-3359RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat LAT Protein
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Cat.#:Lat-337RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Lat Protein, His-tagged
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Cat.#:LAT-7255ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish LAT
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Cat.#:LAT-4816HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human LAT 293 Cell Lysate
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Cat.#:LAT-4817HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human LAT 293 Cell Lysate
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Involved Pathway

LAT involved in several pathways and played different roles in them. We selected most pathways LAT participated on our site, such as Ras signaling pathway, Rap signaling pathway, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
FGF4; FLT1; GAB2; FGF8; GRIN1; RELA; NGFR; FGF1; PIK3R3; PDGFRA
Rap signaling pathway
FGF3; CALML3; RAC3; FGFR2; FGF10; F2RL3; ITGA2B; RAPGEF6; PRKD3; PLCB2
NF-kappa B signaling pathway
CCL19; GM1987; CCL13; UBE2I; NFKBIA; IL1B; CCL21B; IL-8; IRAK4; IKBKB
Natural killer cell mediated cytotoxicity
KLRC1; TNFSF10; TNF; HLA-B; HLA-C; ICAM2; KRAS; LCK; IFNA8; RAET1E
T cell receptor signaling pathway
PDPK1; NFATC1; PDCD1; SLA1; MAP2K7; CBLB; SOS1; PLCG1; PIK3CA; PIK3R5
Fc epsilon RI signaling pathway
PRKCA; PLA2G4B; VAV3; IL3; VAV1; TNF; AKT1; PIK3R5; PLCG2; MAPK9
Fc gamma R-mediated phagocytosis
MARCKS; LAT; ASAP2; ARPC1A; PTPRC; PLD1; WASL; WASF2; LIMK1; FCGR1

Protein Function

LAT has several biochemical functions, for example, SH3/SH2 adaptor activity, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LAT itself. We selected most functions LAT had, and list some proteins which have the same functions with LAT. You can find most of the proteins on our site.
Function
Related Protein
Function SH3/SH2 adaptor activity
Related Protein KHDRBS1; SH3BGR; SLA2; STAP1; SH2D1A; NCK2; SKAP1; CRK; CD28; CRKL
Function protein binding
Related Protein ZNF263; NCAPH; KRTAP3-2; MCM7; ZNF41; RGS16; GJB6; SPRY4; BAZ1B; PATL1
Function protein kinase binding
Related Protein CCNA2; PAX6; SYN1; ELP2; YWHAZ; XBP1; HCLS1; PRKRIP1; ADRA2A; AP2A1

Interacting Protein

LAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LAT here. Most of them are supplied by our site. Hope this information will be useful for your research of LAT.
GRB2; PLCG1; PTPN1

LAT Related Articles

Finch, ML; Passman, AM; et al. Sub-Cellular Localisation Studies May Spuriously Detect the Yes-Associated Protein, YAP, in Nucleoli Leading to Potentially Invalid Conclusions of Its Function. PLOS ONE 10:-(2015).
Du, T; Han, ZY; et al. Patterns of accumulation of miRNAs encoded by herpes simplex virus during productive infection, latency, and on reactivation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:E49-E55(2015).